The last few years have led to a series of discoveries that uncovered statistical properties that are common to a variety of diverse real-world social, information, biological, and technological networks. The goal of the present paper is to investigate the statistical properties of networks of people engaged in distributed problem solving and discuss their significance. We show that problem-solving networks have properties (sparseness, small world, scaling regimes) that are like those displayed by information, biological, and technological networks. More importantly, we demonstrate a previously unreported difference between the distribution of incoming and outgoing links of directed networks. Specifically, the incoming link distributions have sharp cutoffs that are substantially lower than those of the outgoing link distributions (sometimes the outgoing cutoffs are not even present). This asymmetry can be explained by considering the dynamical interactions that take place in distributed problem solving and may be related to differences between each actor’s capacity to process information provided by others and the actor’s capacity to transmit information over the network. We conjecture that the asymmetric link distribution is likely to hold for other human or nonhuman directed networks when nodes represent information processing and using elements.

The US health care system is struggling with a mismatch between the large, simple (low-information) financial flow and the complex (high-information) treatment of individual patients. Efforts to implement cost controls and industrial efficiency that are appropriate for repetitive tasks but not high-complexity tasks lead to poor quality of care. Multiscale complex systems analysis suggests that an important step toward relieving this structural problem is a separation of responsibility for 2 distinct types of tasks: medical care of individual patients and prevention/population health. These distinct tasks require qualitatively different organizational structures. The current use of care providers and organizations for both purposes leads to compromises in organizational process that adversely affect the ability of health care organizations to provide either individual or prevention/population services. Thus, the overall system can be dramatically improved by establishing 2 separate but linked systems with distinct organizational forms: (a) a high-efficiency system performing large-scale repetitive tasks such as screening tests, inoculations, and generic health care, and (b) a high-complexity system treating complex medical problems of individual patients.

Cellular transcription networks are conceptualized as distributed control systems that regulate gene expression.