This page has only limited features, please log in for full access.

Unclaimed
Mohammad H. Al-Sayah
Department of Biology, Chemistry, and Environmental Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Review
Published: 09 August 2021 in Molecules
Reads 0
Downloads 0

Cardiovascular diseases are considered one of the major causes of human death globally. Myocardial infarction (MI), characterized by a diminished flow of blood to the heart, presents the highest rate of morbidity and mortality among all other cardiovascular diseases. These fatal effects have triggered the need for early diagnosis of appropriate biomarkers so that countermeasures can be taken. Cardiac troponin, the central key element of muscle regulation and contraction, is the most specific biomarker for cardiac injury and is considered the “gold standard”. Due to its high specificity, the measurement of cardiac troponin levels has become the predominant indicator of MI. Various forms of diagnostic methods have been developed so far, including chemiluminescence, fluorescence immunoassay, enzyme-linked immunosorbent assay, surface plasmon resonance, electrical detection, and colorimetric protein assays. However, fluorescence-based immunoassays are considered fast, accurate and most sensitive of all in the determination of cardiac troponins post-MI. This review represents the strategies, methods and levels of detection involved in the reported fluorescence-based immunoassays for the detection of cardiac troponin I.

ACS Style

Remya Radha; Syeda Shahzadi; Mohammad Al-Sayah. Fluorescent Immunoassays for Detection and Quantification of Cardiac Troponin I: A Short Review. Molecules 2021, 26, 4812 .

AMA Style

Remya Radha, Syeda Shahzadi, Mohammad Al-Sayah. Fluorescent Immunoassays for Detection and Quantification of Cardiac Troponin I: A Short Review. Molecules. 2021; 26 (16):4812.

Chicago/Turabian Style

Remya Radha; Syeda Shahzadi; Mohammad Al-Sayah. 2021. "Fluorescent Immunoassays for Detection and Quantification of Cardiac Troponin I: A Short Review." Molecules 26, no. 16: 4812.

Journal article
Published: 18 January 2021 in Sustainability
Reads 0
Downloads 0

Two novel nitrogen-rich aminal linked porous organic polymers, NRAPOP-O and NRAPOP-S, have been prepared using a single step-one pot Schiff-base condensation reaction of 9,10-bis-(4,6-diamino-S-triazin-2-yl)benzene and 2-furaldehyde or 2-thiophenecarboxaldehyde, respectively. The two polymers show excellent thermal and physiochemical stabilities and possess high porosity with Brunauer–Emmett–Teller (BET) surface areas of 692 and 803 m2 g−1 for NRAPOP-O and NRAPOP-S, respectively. Because of such porosity, attractive chemical and physical properties, and the availability of redox-active sites and physical environment, the NRAPOPs were able to effectively remove Cr(VI) from solution, reduce it to Cr(III), and simultaneously release it into the solution. The efficiency of the adsorption process was assessed under various influencing factors such as pH, contact time, polymer dosage, and initial concentration of Cr(VI). At the optimum conditions, 100% removal of Cr(VI) was achieved, with simultaneous reduction and release of Cr(III) by NRAPOP-O with 80% efficiency. Moreover, the polymers can be easily regenerated by the addition of reducing agents such as hydrazine without significant loss in the detoxication of Cr(VI).

ACS Style

Muhammad Sabri; Ziad Sara; Mohammad Al-Sayah; Taleb Ibrahim; Mustafa Khamis; Oussama El-Kadri. Simultaneous Adsorption and Reduction of Cr(VI) to Cr(III) in Aqueous Solution Using Nitrogen-Rich Aminal Linked Porous Organic Polymers. Sustainability 2021, 13, 923 .

AMA Style

Muhammad Sabri, Ziad Sara, Mohammad Al-Sayah, Taleb Ibrahim, Mustafa Khamis, Oussama El-Kadri. Simultaneous Adsorption and Reduction of Cr(VI) to Cr(III) in Aqueous Solution Using Nitrogen-Rich Aminal Linked Porous Organic Polymers. Sustainability. 2021; 13 (2):923.

Chicago/Turabian Style

Muhammad Sabri; Ziad Sara; Mohammad Al-Sayah; Taleb Ibrahim; Mustafa Khamis; Oussama El-Kadri. 2021. "Simultaneous Adsorption and Reduction of Cr(VI) to Cr(III) in Aqueous Solution Using Nitrogen-Rich Aminal Linked Porous Organic Polymers." Sustainability 13, no. 2: 923.

Original paper
Published: 04 January 2021 in International Journal of Environmental Science and Technology
Reads 0
Downloads 0

In the present work, continuous fixed-bed column and batch studies were undertaken to investigate the efficiency of iron-based metal–organic framework (Fe-BTC) for the removal of methyl orange as a model contaminant from aqueous solutions. The batch experiments were carried out by varying operational parameters such as adsorbent dosage, pH, temperature, and initial contaminant concentration. The results showed that Fe-BTC had a high removal efficiency under a wide pH range. The equilibrium data were best fitted by the Langmuir model with a maximum adsorption capacity of 100.3 mg g−1 at 298 K. In order to assess the industrial feasibility of Fe-BTC, fixed-bed column studies were conducted to obtain breakthrough curves, breakthrough and saturation times, and maximum uptakes at different bed heights. The breakthrough time was 20.0 and 46.2 h at 0.75 and 1.5 cm bed depths, respectively. The bed removal efficiency was 35.2 and 46.7% at 0.75 and 1.5 cm bed depth, respectively. The bed maximum adsorption capacity was 20.2 and 21.6 mg/g at 0.75 and 1.5 cm bed depths, respectively. Moreover, the application of empirical breakthrough curve models showed good agreement with the modified dose response model (R2> 0.99). Also, the analytical solution of the advection–dispersion–adsorption mass transfer equation showed an excellent fit to the experimental breakthrough data (R2> 0.99). Further, the analytical model was utilized to predict the length of the mass transfer zone as a function of the bed depth and to construct a 3D surface plot that can be utilized to predict the breakthrough at different bed depths.

ACS Style

A. Karami; R. Sabouni; M. H. Al-Sayah; A. Aidan. Adsorption potentials of iron-based metal–organic framework for methyl orange removal: batch and fixed-bed column studies. International Journal of Environmental Science and Technology 2021, 1 -16.

AMA Style

A. Karami, R. Sabouni, M. H. Al-Sayah, A. Aidan. Adsorption potentials of iron-based metal–organic framework for methyl orange removal: batch and fixed-bed column studies. International Journal of Environmental Science and Technology. 2021; ():1-16.

Chicago/Turabian Style

A. Karami; R. Sabouni; M. H. Al-Sayah; A. Aidan. 2021. "Adsorption potentials of iron-based metal–organic framework for methyl orange removal: batch and fixed-bed column studies." International Journal of Environmental Science and Technology , no. : 1-16.

Journal article
Published: 22 July 2020 in Journal of Water and Health
Reads 0
Downloads 0

The outbreak of coronavirus (COVID-19) has led to a broad use of chemical disinfectants in order to sterilize public spaces and prevent contamination. This paper surveys the chemicals that are effective in deactivating the virus and their mode of action. It presents the different chemical classes of disinfectants and identifies the chemical features of these compounds that pertain to their biocidal activity, relevant to surface/water disinfection.

ACS Style

Mohammad Hussein Al-Sayah. Chemical disinfectants of COVID-19: an overview. Journal of Water and Health 2020, 18, 843 -848.

AMA Style

Mohammad Hussein Al-Sayah. Chemical disinfectants of COVID-19: an overview. Journal of Water and Health. 2020; 18 (5):843-848.

Chicago/Turabian Style

Mohammad Hussein Al-Sayah. 2020. "Chemical disinfectants of COVID-19: an overview." Journal of Water and Health 18, no. 5: 843-848.

Journal article
Published: 11 June 2020 in IEEE Transactions on Components, Packaging and Manufacturing Technology
Reads 0
Downloads 0

Flexible implantable bioelectrodes have the potential to advance neural sensing and muscle stimulation, especially in peripheral nerve injuries. In such cases, the application of electrical stimulation to muscles prevents muscular atrophy and helps to bridge the gap between the injured nerve and the corresponding muscle. This article investigates the fabrication and characterization of a novel, cost-effective, flexible bioelectrode, based on silicone polymer (polysiloxane) and titanium (IV) dioxide. Samples were synthesized and evaluated for their electrochemical and mechanical properties. The bioelectrodes fabricated in this article exhibited promising electrical and mechanical characteristics. The ductile properties for the samples showed an elongation of 293% ± 27.1% before breaking and an elastic modulus of 32.9 ± 5.01 kPa. The impedance at 1 kHz (a standard frequency value to measure the neural activity) was equal to 198 $\text{k}\Omega $ . The electrode’s impedance found at 7 MHz was 0.35 $\text{k}\Omega $ , thus supporting its potential to be employed in implantable electrode applications.

ACS Style

Aseel Alatoom; Amani Al-Othman; Hasan Al-Nashash; Mohammad Al-Sayah. Development and Characterization of Novel Composite and Flexible Electrode Based on Titanium Dioxide. IEEE Transactions on Components, Packaging and Manufacturing Technology 2020, 10, 1079 -1087.

AMA Style

Aseel Alatoom, Amani Al-Othman, Hasan Al-Nashash, Mohammad Al-Sayah. Development and Characterization of Novel Composite and Flexible Electrode Based on Titanium Dioxide. IEEE Transactions on Components, Packaging and Manufacturing Technology. 2020; 10 (7):1079-1087.

Chicago/Turabian Style

Aseel Alatoom; Amani Al-Othman; Hasan Al-Nashash; Mohammad Al-Sayah. 2020. "Development and Characterization of Novel Composite and Flexible Electrode Based on Titanium Dioxide." IEEE Transactions on Components, Packaging and Manufacturing Technology 10, no. 7: 1079-1087.

Journal article
Published: 10 June 2020 in Applied and Environmental Soil Science
Reads 0
Downloads 0

Phytoextraction is an effective and environment-friendly approach for remediation of soil polluted with toxic metals. Portulaca oleracea is a potential hyperaccumulator of Cr(VI) from polluted soil. In this study, the effect of soil organic content, pH, and sulphate concentration on phytoextraction of Cr(VI) using Portulaca oleracea was investigated. Seedlings of Portulaca oleracea were grown in soils with (i) three organic content compositions, (ii) six levels of pH, and (iii) six concentrations of sulphate salts; all were irrigated with Cr(VI) solutions at 200 ppm concentration. Chromium concentration in different tissues of plants was monitored under the variant conditions. Results indicated that the uptake of Cr(VI) by Portulaca oleracea is favoured at (i) low organic content soil (0.42%), (ii) slightly alkaline pH range (∼8), and (iii) with sulphate concentration in the range of 300–600 ppm.

ACS Style

Ayman Alyazouri; Roger Jewsbury; Hassan Tayim; Paul Humphreys; Mohammad H. Al-Sayah. Uptake of Chromium by Portulaca Oleracea from Soil: Effects of Organic Content, pH, and Sulphate Concentration. Applied and Environmental Soil Science 2020, 2020, 1 -10.

AMA Style

Ayman Alyazouri, Roger Jewsbury, Hassan Tayim, Paul Humphreys, Mohammad H. Al-Sayah. Uptake of Chromium by Portulaca Oleracea from Soil: Effects of Organic Content, pH, and Sulphate Concentration. Applied and Environmental Soil Science. 2020; 2020 ():1-10.

Chicago/Turabian Style

Ayman Alyazouri; Roger Jewsbury; Hassan Tayim; Paul Humphreys; Mohammad H. Al-Sayah. 2020. "Uptake of Chromium by Portulaca Oleracea from Soil: Effects of Organic Content, pH, and Sulphate Concentration." Applied and Environmental Soil Science 2020, no. : 1-10.

Polymers and biopolymers
Published: 05 May 2020 in Journal of Materials Science
Reads 0
Downloads 0

Development of multifunctional porous organic polymers containing heteroatoms is of significant importance for practical environmental applications including sequestering of greenhouse gasses, radioactive nucleotides, and heavy metals ions. In this work, two nitrogen-rich aminal-linked luminescent porous organic polymers (NRAPOP-1 and NRAPOP-2) bearing anthracene moiety were successfully synthesized by reacting 9,10-bis-(4,6-diamino-S-triazin-2-yl)anthracene with 1,4-dibenzaldehyde or thieno[2,3-b]thiophene-2,5-dicarbaldehyde through one-pot Schiff base condensation reaction. NRAPOP-1 and NRAPOP-2 exhibit permanent porosity with Brunauer–Emmett–Teller (BET) surface areas of 544 m2 g−1 and 424 m2 g−1, respectively. Structural analysis, elemental composition, thermal stability, and morphology studies were conducted using Fourier transform infrared spectroscopy, elemental analysis, thermogravimetric analysis, and scanning electron microscopy. The two newly synthesized polymers showed excellent adsorption of iodine vapor with an uptake of up to 281 wt.% at 80 °C and 1 bar, which is among the highest value reported to date for aminal-linked porous organic polymers. Furthermore, fluorescence spectroscopic investigations of aqueous suspensions of the NRAPOPs revealed selective fluorescence quenching by metal ions with high sensitivity for Fe3+ ions. The strategy of constructing highly porous organic polymers by linking heteroatom-rich building blocks that also comprise luminescent moieties should pave the way for the preparation of novel materials for multienvironmental applications.

ACS Style

Susan Sen; Mohammad H. Al-Sayah; Mohammed S. Mohammed; Ideisan I. Abu-Abdoun; Oussama M. El-Kadri. Multifunctional nitrogen-rich aminal-linked luminescent porous organic polymers for iodine enrichment and selective detection of Fe3+ ions. Journal of Materials Science 2020, 55, 10896 -10909.

AMA Style

Susan Sen, Mohammad H. Al-Sayah, Mohammed S. Mohammed, Ideisan I. Abu-Abdoun, Oussama M. El-Kadri. Multifunctional nitrogen-rich aminal-linked luminescent porous organic polymers for iodine enrichment and selective detection of Fe3+ ions. Journal of Materials Science. 2020; 55 (24):10896-10909.

Chicago/Turabian Style

Susan Sen; Mohammad H. Al-Sayah; Mohammed S. Mohammed; Ideisan I. Abu-Abdoun; Oussama M. El-Kadri. 2020. "Multifunctional nitrogen-rich aminal-linked luminescent porous organic polymers for iodine enrichment and selective detection of Fe3+ ions." Journal of Materials Science 55, no. 24: 10896-10909.

Journal article
Published: 01 November 2019 in Journal of Nanoscience and Nanotechnology
Reads 0
Downloads 0

Typical methods used in cancer treatment, including chemotherapy, are debilitating because of the various adverse side effects experienced by cancer patients. The free drug injected into the patient at given doses affects both healthy and cancerous cells. Therefore, novel methods are being researched to ensure the selectivity of the treatment. The purpose of this study is to test the release of a model fluorescent drug, calcein, from echogenic stealth liposomes, triggered by lowfrequency pulsed ultrasound. Several experimental parameters related to the ultrasound (US) and the investigated liposomes were varied in order to examine their effect on the acoustic release. Upon analysis of experimental results, the study concluded that release can be maximized by optimizing the sonication frequency, power density, and US pulse duration. When a non-isothermal chamber is used to conduct the experiments, it is important to have longer ‘Off’ than ‘On’ US periods in order to avoid overheating the liposomes. Applying such pulsation pattern can also be utilized to achieve slower release rates, which safely meet the desired drug levels at the end of the session. Our study also concluded that optimizing the liposome concentration is vital to delivering desired drug doses. Additionally, the type of lipids used in the synthesis should be carefully selected to produce stable yet acoustically sensitive liposomes capable of releasing at desired rates.

ACS Style

Salma Elgaili Ahmed; Hesham G. Moussa; Ana Margarida Martins; Yassmine Abbas; Mohammad Al-Sayah; Ghaleb A. Husseini. Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes. Journal of Nanoscience and Nanotechnology 2019, 19, 6899 -6906.

AMA Style

Salma Elgaili Ahmed, Hesham G. Moussa, Ana Margarida Martins, Yassmine Abbas, Mohammad Al-Sayah, Ghaleb A. Husseini. Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes. Journal of Nanoscience and Nanotechnology. 2019; 19 (11):6899-6906.

Chicago/Turabian Style

Salma Elgaili Ahmed; Hesham G. Moussa; Ana Margarida Martins; Yassmine Abbas; Mohammad Al-Sayah; Ghaleb A. Husseini. 2019. "Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes." Journal of Nanoscience and Nanotechnology 19, no. 11: 6899-6906.

Research article
Published: 19 June 2019 in ACS Biomaterials Science & Engineering
Reads 0
Downloads 0

The use of targeted liposomes encapsulating chemotherapy drugs enhances the specific targeting of cancer cells, thus, reducing the side effects of these agents and providing a more patient-friendly treatment. Targeted pegylated (stealth) liposomes have the ability to safely deliver their loaded drugs to the cancer cells by targeting specific receptors overly expressed on the surface of these cells. Applying ultrasound as an external stimulus will safely trigger drug release from these liposomes in a controlled manner. In this study, we investigated the release kinetics of the model drug “calcein” from targeted liposomes sonicated with low-frequency ultrasound (20-kHz). Our results showed that pegylated liposomes were more sonosensitive compared to non-pegylated liposomes. A comparison of the effect of three targeting moieties conjugated to the surface of pegylated liposomes, namely human serum albumin (HSA), transferrin (Tf) and arginylglycylaspartic acid (RGD), on calcein release kinetics was conducted. The fluorescence results showed that HSA-PEG and Tf-PEG liposomes were more sonosensitive (showing higher calcein release following the exposure to pulsed LFUS) compared to the control pegylated liposomes. Thus, adding more acoustic benefits to their targeting efficacy.

ACS Style

Nahid S. Awad; Vinod Paul; Mohamad Mahmoud; Nour M. Al Sawaftah; Paul S. Kawak; Mohammad H. Al Sayah; Ghaleb A. Husseini. Effect of Pegylation and Targeting Moieties on the Ultrasound-Mediated Drug Release from Liposomes. ACS Biomaterials Science & Engineering 2019, 6, 48 -57.

AMA Style

Nahid S. Awad, Vinod Paul, Mohamad Mahmoud, Nour M. Al Sawaftah, Paul S. Kawak, Mohammad H. Al Sayah, Ghaleb A. Husseini. Effect of Pegylation and Targeting Moieties on the Ultrasound-Mediated Drug Release from Liposomes. ACS Biomaterials Science & Engineering. 2019; 6 (1):48-57.

Chicago/Turabian Style

Nahid S. Awad; Vinod Paul; Mohamad Mahmoud; Nour M. Al Sawaftah; Paul S. Kawak; Mohammad H. Al Sayah; Ghaleb A. Husseini. 2019. "Effect of Pegylation and Targeting Moieties on the Ultrasound-Mediated Drug Release from Liposomes." ACS Biomaterials Science & Engineering 6, no. 1: 48-57.

Research article
Published: 09 May 2019 in Journal of the American Chemical Society
Reads 0
Downloads 0

This paper describes the relationship between molecular structure, and the rectification of tunneling current, in tunneling junctions based on self-assembled monolayers (SAMs). Simple molecular dipoles (from amide, urea, and thiourea groups) were introduced into junctions with the structure AgTS/S(CH2)nR(CH2)mCH3//Ga2O3/EGaIn. Here, R is an n-alkyl fragment (−CH2−)2 or 3, an amide group (either −CONH– or −NHCO–), a urea group (−NHCONH–), or a thiourea group (−NHCSNH–). The amide, urea, or thiourea groups introduce a localized electric dipole moment into the SAM and change the polarizability of that section of the SAM, but do not produce large, electronically delocalized groups or change other aspects of the tunneling barrier. This local change in electronic properties correlates with a statistically significant, but not large, rectification of current (r+) at ±1.0 V (up to r+ ~20). The results of this work demonstrate that the simplest form of rectification of current at ±1.0 V, in EGaIn junctions, is an interfacial effect, and is caused by a change in the work function of the silver electrode due to the proximity of the dipole associated with the amide (or related) group, not to a change in the width or mean height of the tunneling barrier.

ACS Style

Mostafa Baghbanzadeh; Lee Belding; Li Yuan; Junwoo Park; Mohammad H. Al-Sayah; Carleen M. Bowers; George M. Whitesides. Dipole-Induced Rectification Across AgTS/SAM//Ga2O3/EGaIn Junctions. Journal of the American Chemical Society 2019, 141, 8969 -8980.

AMA Style

Mostafa Baghbanzadeh, Lee Belding, Li Yuan, Junwoo Park, Mohammad H. Al-Sayah, Carleen M. Bowers, George M. Whitesides. Dipole-Induced Rectification Across AgTS/SAM//Ga2O3/EGaIn Junctions. Journal of the American Chemical Society. 2019; 141 (22):8969-8980.

Chicago/Turabian Style

Mostafa Baghbanzadeh; Lee Belding; Li Yuan; Junwoo Park; Mohammad H. Al-Sayah; Carleen M. Bowers; George M. Whitesides. 2019. "Dipole-Induced Rectification Across AgTS/SAM//Ga2O3/EGaIn Junctions." Journal of the American Chemical Society 141, no. 22: 8969-8980.

Articles
Published: 15 March 2019 in Artificial Cells, Nanomedicine, and Biotechnology
Reads 0
Downloads 0

Targeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumour site. Once at the tumour site, it is important that these liposomes are triggered to release their load in a controlled and effective manner. In this study, pegylated (stealth) liposomes conjugated to human serum albumin (HSA) were investigated for the delivery of a model drug (calcein) to breast cancer cells. The fluorescent results showed that calcein uptake by the two breast cancer cell lines (MDA-MB-231 and MCF-7) was significantly higher with the HSA-PEG liposomes compared to the non-targeted control liposomes. Furthermore, the exposure to low-frequency ultrasound (LFUS) resulted in a statistically significant uptake of calcein compared to the uptake without ultrasound. The described drug delivery (DD) system, which involves combining the targeted liposomal formulation with ultrasonic triggering techniques, promises a safe, effective and site-specific breast cancer therapy.

ACS Style

Nahid S. Awad; Vinod Paul; Mohammad H. Al-Sayah; Ghaleb A. Husseini. Ultrasonically controlled albumin-conjugated liposomes for breast cancer therapy. Artificial Cells, Nanomedicine, and Biotechnology 2019, 47, 705 -714.

AMA Style

Nahid S. Awad, Vinod Paul, Mohammad H. Al-Sayah, Ghaleb A. Husseini. Ultrasonically controlled albumin-conjugated liposomes for breast cancer therapy. Artificial Cells, Nanomedicine, and Biotechnology. 2019; 47 (1):705-714.

Chicago/Turabian Style

Nahid S. Awad; Vinod Paul; Mohammad H. Al-Sayah; Ghaleb A. Husseini. 2019. "Ultrasonically controlled albumin-conjugated liposomes for breast cancer therapy." Artificial Cells, Nanomedicine, and Biotechnology 47, no. 1: 705-714.

Research article
Published: 14 November 2018 in ACS Omega
Reads 0
Downloads 0

A novel luminescent azo-linked polymer (ALP) has been constructed from 1,3,6,8-tetra(4-aminophenyl)pyrene using a copper(I)-catalyzed oxidative homocoupling reaction. The polymer displays high porosity with a Brunauer-Emmett-Teller surface area of 1259 m2 g-1 and narrow pore size distribution (1.06 nm) and is able to take up a significant amount of CO2 (2.89 mmol g-1) at 298 K and 1.00 bar with a high isosteric heat of adsorption of 27.5 kJ mol-1. Selectivity studies applying the ideal adsorbed solution theory revealed that the novel polymer has moderately good selectivities for CO2/N2 (55.1) and CO2/CH4 (10.9). Furthermore, the ALP shows fluorescence quenching in the presence of Hg2+, Pb2+, Tl+, and Al3+ ions. Compared with these ions, the ALP showed no sensitivity to light metal ions such as Na+, K+, and Ca2+ in ethanol-water solution, clearly indicating the high selectivity of the ALP toward heavy metal ions. The exceptional physiochemical stability, high porosity, and strong luminescence make this polymer an excellent candidate as a fluorescent chemical sensor for the detection of heavy metal ions.

ACS Style

Oussama M. El-Kadri; Tsemre-Dingel Tessema; Ruaa M. Almotawa; Ravi K. Arvapally; Mohammad H. Al-Sayah; Mohammad A. Omary; Hani M. El-Kaderi. Pyrene Bearing Azo-Functionalized Porous Nanofibers for CO2 Separation and Toxic Metal Cation Sensing. ACS Omega 2018, 3, 15510 -15518.

AMA Style

Oussama M. El-Kadri, Tsemre-Dingel Tessema, Ruaa M. Almotawa, Ravi K. Arvapally, Mohammad H. Al-Sayah, Mohammad A. Omary, Hani M. El-Kaderi. Pyrene Bearing Azo-Functionalized Porous Nanofibers for CO2 Separation and Toxic Metal Cation Sensing. ACS Omega. 2018; 3 (11):15510-15518.

Chicago/Turabian Style

Oussama M. El-Kadri; Tsemre-Dingel Tessema; Ruaa M. Almotawa; Ravi K. Arvapally; Mohammad H. Al-Sayah; Mohammad A. Omary; Hani M. El-Kaderi. 2018. "Pyrene Bearing Azo-Functionalized Porous Nanofibers for CO2 Separation and Toxic Metal Cation Sensing." ACS Omega 3, no. 11: 15510-15518.

Original paper
Published: 16 May 2018 in Cellulose
Reads 0
Downloads 0

Natural cellulose-based fibers, such as cotton, have been investigated as oil sorbent to remediate and recover oil spills. The unmodified fibers are hydrophilic and have a high capacity to absorb water. To circumvent this drawback, the hydrophobicity of fibers is usually enhanced by chemical modification using solution-based processes that produce significant amounts of chemical waste. In the present study, gas–solid solvent-free silylation reaction was used to graft alkyl groups on cotton fibers. The modified cotton fibers were characterized by IR-spectroscopy, TGA analysis and SEM–EDS. The degree of substitution varied between 0.1 and 0.3 per glucose residue. The ability of the fibers to remove oil from the surface of simulated sea-water was investigated and all the modified fibers have adsorption capacity at least five times that of unmodified cotton. To optimize the adsorption capacity, factors that affect oil adsorption were investigated, namely the effect of fiber–oil contact time, temperature, and length of the grafted alkyl chains. Cotton fibers grafted with dialkyl substituted silyl ethers, through solvent-free silylation reaction, were found to have the best adsorption capacity of ~ 18 g oil/g of modified cotton with a fiber–oil contact time of 10 min at 25 °C.

ACS Style

Khalid Jarrah; Soleiman Hisaindee; Mohammad H. Al-Sayah. Preparation of oil sorbents by solvent-free grafting of cellulose cotton fibers. Cellulose 2018, 25, 4093 -4106.

AMA Style

Khalid Jarrah, Soleiman Hisaindee, Mohammad H. Al-Sayah. Preparation of oil sorbents by solvent-free grafting of cellulose cotton fibers. Cellulose. 2018; 25 (7):4093-4106.

Chicago/Turabian Style

Khalid Jarrah; Soleiman Hisaindee; Mohammad H. Al-Sayah. 2018. "Preparation of oil sorbents by solvent-free grafting of cellulose cotton fibers." Cellulose 25, no. 7: 4093-4106.

Journal article
Published: 12 April 2018 in Artificial Cells, Nanomedicine, and Biotechnology
Reads 0
Downloads 0

A new modality of drug targeting to tumors has been proposed. The ligand-mediated approach, that already increases the therapeutic index of the drug, can still be optimized by the encapsulation of the drug into sonosensitive nanoparticles. In this work, an endogenous ligand, estrone, was used to synthesize doxorubicin-encapsulating liposomes for estrogen receptor (ER)-positive breast cancer therapy with cyanuric chloride (2,4,6 trichloro-1,3,5 triazine) being used as a linking molecule to attach 3-OH group of estrone to the surface of liposomes. Then, drug release from liposomes was studied using ultrasound waves as a triggering mechanism with different frequencies and power densities. In addition, drug uptake by two cell lines ER-positive (MCF-7) and ER-negative (MDA-MB-231) was assessed, with the former cell line being examined later to study the synergetic effect of the receptor mediator targeting and ultrasound trigger. The sizes of the liposomes loaded with calcein (as a doxorubicin model drug) were determined by dynamic light scattering, and they were characterized as large unilamellar vesicles (LUVs). The release from the prepared liposomes triggered by ultrasound (US) waves at low frequency (20 kHz) and high frequency (1.07 and 3.24 MHz), at several power densities, was determined by monitoring the changes in calcein fluorescence, using a spectrofluorometer. Increasing power densities showed a significant effect on release at high frequencies and during the first two US pulses at low frequency. The echogenicity of the liposomes was proven and characterized at different power densities and frequencies. To confirm the viability of the carrier as a doxorubicin carrier, doxorubicin-encapsulating liposomes were prepared using the ammonium sulfate transmembrane gradient method. The liposomes were LUVs and were US-sensitive, exhibiting similar behavior to calcein-encapsulating liposomes. The calcein uptake by an ER + cell line (MCF-7) was compared with the uptake by an ER-cell line (MDA-MB-231). The MCF-7 uptake was significantly higher than the MDA-MB-231 uptake, which proved the targeting potential of estrone-conjugated liposomes. The exposure to low-frequency ultrasound (LFUS) revealed a statistically significant uptake of calcein compared to uptake without ultrasound. The described drug delivery (DD) system, comprising a new echogenic liposomal formulation, promises a non-immunogenic and site-specific biomedical approach to ER-positive breast cancer therapy.

ACS Style

Najla M. Salkho; Vinod Paul; Pierre Kawak; Rute F. Vitor; Ana Martins; Mohammad Al Sayah; Ghaleb A. Husseini. Ultrasonically controlled estrone-modified liposomes for estrogen-positive breast cancer therapy. Artificial Cells, Nanomedicine, and Biotechnology 2018, 46, 462 -472.

AMA Style

Najla M. Salkho, Vinod Paul, Pierre Kawak, Rute F. Vitor, Ana Martins, Mohammad Al Sayah, Ghaleb A. Husseini. Ultrasonically controlled estrone-modified liposomes for estrogen-positive breast cancer therapy. Artificial Cells, Nanomedicine, and Biotechnology. 2018; 46 (sup2):462-472.

Chicago/Turabian Style

Najla M. Salkho; Vinod Paul; Pierre Kawak; Rute F. Vitor; Ana Martins; Mohammad Al Sayah; Ghaleb A. Husseini. 2018. "Ultrasonically controlled estrone-modified liposomes for estrogen-positive breast cancer therapy." Artificial Cells, Nanomedicine, and Biotechnology 46, no. sup2: 462-472.

Dataset
Published: 01 January 2017 in nano Online
Reads 0
Downloads 0

The use of liposomes as carriers for chemotherapeutic agents in combination with ultrasound as a stimulus to control the time and space of the drug release is a promising approach for cancer treatment, as it can reduce the side effects caused by conventional chemotherapy. This in vitro study investigated the triggered release of calcein from stealth (PEGylated) and non-stealth (non-PEGylated) liposomes, using ultrasound at low (20 kHz) and high (1 and 3 MHz) frequencies, and at different power densities. Release was monitored by the increase in fluorescence due to relieving of calcein’s self-quenching upon dilution when the model drug leaks out of the liposomes. The results showed that, independent of the power density, the release was highest at 20 kHz. For the same frequency, release usually increased with increasing power densities. Additionally, for release at 20 kHz, a comparison was done for PEGylated and non-PEGylated liposomes, at two pH values: 5.2 and 7.4. The results were then compared to previously published studies. In all cases, the mechanism of release seems to involve cavitation events that either pierce a hole in or shear open the liposomes, as all the determined power densities are above the transient cavitation threshold.

ACS Style

Salma E. Ahmed; Hesham G. Moussa; Ana Margarida Martins; Mohammad H. Al-Sayah; Ghaleb A. Husseini. Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes. nano Online 2017, 1 .

AMA Style

Salma E. Ahmed, Hesham G. Moussa, Ana Margarida Martins, Mohammad H. Al-Sayah, Ghaleb A. Husseini. Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes. nano Online. 2017; ():1.

Chicago/Turabian Style

Salma E. Ahmed; Hesham G. Moussa; Ana Margarida Martins; Mohammad H. Al-Sayah; Ghaleb A. Husseini. 2017. "Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes." nano Online , no. : 1.

Journal article
Published: 01 February 2016 in Journal of Nanoscience and Nanotechnology
Reads 0
Downloads 0

Folic acid (FA) is one of the most utilized moieties in active (ligand) drug delivery. The folate receptor is widely expressed on the surface of several cell lines and tumors; including ovarian, brain, kidney, breast, and lung cancers. During our previous experiments with Doxorubicin (Dox) encapsulated in folate-targeted micelles, we found that flow cytometry underestimated the amount of drug that accu- mulates inside cells. We attributed this effect to the quenching of Dox by FA and herein investigate this phenomenon in an attempt to obtain a correction factor that could be applied to the fluorescence of Dox in the presence of FA. Initially, we examine the effect of pH on the fluorescence spectra of FA, Dox, equimolar solutions of FA and Dox in water, HCI (0.1 M), and NaOH (0.1 M) solutions. We then measure the effect of the gradual increase of FA concentration on the fluorescence intensity of Dox in phosphate-buffered saline (PBS) solutions (pH of 7.4). Using the Stern-Volmer equation, we estimate the association constant of FA-Dox to be K(SV) = 1.5 x 10(4) M(-1). Such an association constant indicates that at the concentrations of FA used in targeted drug delivery systems, a significant concentration of Dox exists as FA-Dox complexes with a quenched fluorescence. Therefore, we conclude that when Dox is used in FA-active drug delivery systems, a correction factor is needed to predict the correct fluorescence intensity of agent in vitro and in vivo.

ACS Style

Ghaleb A. Husseini; Sofian Kanan; Mohammad Al-Sayah. Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers. Journal of Nanoscience and Nanotechnology 2016, 16, 1410 -1414.

AMA Style

Ghaleb A. Husseini, Sofian Kanan, Mohammad Al-Sayah. Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers. Journal of Nanoscience and Nanotechnology. 2016; 16 (2):1410-1414.

Chicago/Turabian Style

Ghaleb A. Husseini; Sofian Kanan; Mohammad Al-Sayah. 2016. "Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers." Journal of Nanoscience and Nanotechnology 16, no. 2: 1410-1414.

Journal article
Published: 01 January 2016 in European Journal of Nanomedicine
Reads 0
Downloads 0

The use of liposomes as carriers for chemotherapeutic agents in combination with ultrasound as a stimulus to control the time and space of the drug release is a promising approach for cancer treatment, as it can reduce the side effects caused by conventional chemotherapy. This in vitro study investigated the triggered release of calcein from stealth (PEGylated) and non-stealth (non-PEGylated) liposomes, using ultrasound at low (20 kHz) and high (1 and 3 MHz) frequencies, and at different power densities. Release was monitored by the increase in fluorescence due to relieving of calcein’s self-quenching upon dilution when the model drug leaks out of the liposomes. The results showed that, independent of the power density, the release was highest at 20 kHz. For the same frequency, release usually increased with increasing power densities. Additionally, for release at 20 kHz, a comparison was done for PEGylated and non-PEGylated liposomes, at two pH values: 5.2 and 7.4. The results were then compared to previously published studies. In all cases, the mechanism of release seems to involve cavitation events that either pierce a hole in or shear open the liposomes, as all the determined power densities are above the transient cavitation threshold.

ACS Style

Salma Elgaili Ahmed; Hesham G. Moussa; Ana Margarida Martins; Mohammad Al-Sayah; Ghaleb A. Husseini. Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes. European Journal of Nanomedicine 2016, 8, 1 .

AMA Style

Salma Elgaili Ahmed, Hesham G. Moussa, Ana Margarida Martins, Mohammad Al-Sayah, Ghaleb A. Husseini. Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes. European Journal of Nanomedicine. 2016; 8 (1):1.

Chicago/Turabian Style

Salma Elgaili Ahmed; Hesham G. Moussa; Ana Margarida Martins; Mohammad Al-Sayah; Ghaleb A. Husseini. 2016. "Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes." European Journal of Nanomedicine 8, no. 1: 1.

Articles
Published: 19 October 2015 in Supramolecular Chemistry
Reads 0
Downloads 0

This paper reports the synthesis of a new molecule, 5-(dimethylamino)naphthalene-1-sulfonic acid 2,3-bis(3-phenylureido)phenyl ester (1), as an optical probe for anions. The effect of the presence of various anions on the spectroscopic properties of 1 was examined using UV–vis absorption spectroscopy, fluorescence and 1H NMR titration experiments. Strong binding of 1 to carboxylate, oxalate, cyanide and dihydrogen phosphate anions resulted in an increase in the emission of 1 and changes in its 1H NMR chemical shifts. Binding constants of 1 to anions were also calculated based on the binding isotherms derived from the spectroscopic titrations.

ACS Style

Mohammad H. Al-Sayah; Aya Abdalla; Mohammad K. Shehab. A dansyl-based optical probe for detection of singly and doubly charged anions. Supramolecular Chemistry 2015, 28, 224 -230.

AMA Style

Mohammad H. Al-Sayah, Aya Abdalla, Mohammad K. Shehab. A dansyl-based optical probe for detection of singly and doubly charged anions. Supramolecular Chemistry. 2015; 28 (3-4):224-230.

Chicago/Turabian Style

Mohammad H. Al-Sayah; Aya Abdalla; Mohammad K. Shehab. 2015. "A dansyl-based optical probe for detection of singly and doubly charged anions." Supramolecular Chemistry 28, no. 3-4: 224-230.

Zuschrift
Published: 09 October 2015 in Angewandte Chemie
Reads 0
Downloads 0

This work examines charge transport (CT) through self‐assembled monolayers (SAMs) of oligoglycines having an N‐terminal cysteine group that anchors the molecule to a gold substrate, and demonstrate that CT is rapid (relative to SAMs of n‐alkanethiolates). Comparisons of rates of charge transport‐using junctions with the structure AuTS/SAM//Ga2O3/EGaIn (across these SAMs of oligoglycines, and across SAMs of a number of structurally and electronically related molecules) established that rates of charge tunneling along SAMs of oligoglycines are comparable to that along SAMs of oligophenyl groups (of comparable length). The mechanism of tunneling in oligoglycines is compatible with superexchange, and involves interactions among high‐energy occupied orbitals in multiple, consecutive amide bonds, which may by separated by one to three methylene groups. This mechanistic conclusion is supported by density functional theory (DFT).

ACS Style

Mostafa Baghbanzadeh; Carleen M. Bowers; Dmitrij Rappoport; Tomasz Żaba; Mathieu Gonidec; Mohammad Al-Sayah; Dr. Piotr Cyganik; Dr. Alan Aspuru‐Guzik; Dr. George M. Whitesides. Charge Tunneling along Short Oligoglycine Chains. Angewandte Chemie 2015, 127, 14956 -14960.

AMA Style

Mostafa Baghbanzadeh, Carleen M. Bowers, Dmitrij Rappoport, Tomasz Żaba, Mathieu Gonidec, Mohammad Al-Sayah, Dr. Piotr Cyganik, Dr. Alan Aspuru‐Guzik, Dr. George M. Whitesides. Charge Tunneling along Short Oligoglycine Chains. Angewandte Chemie. 2015; 127 (49):14956-14960.

Chicago/Turabian Style

Mostafa Baghbanzadeh; Carleen M. Bowers; Dmitrij Rappoport; Tomasz Żaba; Mathieu Gonidec; Mohammad Al-Sayah; Dr. Piotr Cyganik; Dr. Alan Aspuru‐Guzik; Dr. George M. Whitesides. 2015. "Charge Tunneling along Short Oligoglycine Chains." Angewandte Chemie 127, no. 49: 14956-14960.

Communication
Published: 09 October 2015 in Angewandte Chemie International Edition
Reads 0
Downloads 0

This work examines charge transport (CT) through self‐assembled monolayers (SAMs) of oligoglycines having an N‐terminal cysteine group that anchors the molecule to a gold substrate, and demonstrate that CT is rapid (relative to SAMs of n‐alkanethiolates). Comparisons of rates of charge transport‐using junctions with the structure AuTS/SAM//Ga2O3/EGaIn (across these SAMs of oligoglycines, and across SAMs of a number of structurally and electronically related molecules) established that rates of charge tunneling along SAMs of oligoglycines are comparable to that along SAMs of oligophenyl groups (of comparable length). The mechanism of tunneling in oligoglycines is compatible with superexchange, and involves interactions among high‐energy occupied orbitals in multiple, consecutive amide bonds, which may by separated by one to three methylene groups. This mechanistic conclusion is supported by density functional theory (DFT).

ACS Style

Mostafa Baghbanzadeh; Carleen M. Bowers; Dmitrij Rappoport; Tomasz Żaba; Mathieu Gonidec; Mohammad Al-Sayah; Dr. Piotr Cyganik; Dr. Alan Aspuru‐Guzik; Dr. George M. Whitesides. Charge Tunneling along Short Oligoglycine Chains. Angewandte Chemie International Edition 2015, 54, 14743 -14747.

AMA Style

Mostafa Baghbanzadeh, Carleen M. Bowers, Dmitrij Rappoport, Tomasz Żaba, Mathieu Gonidec, Mohammad Al-Sayah, Dr. Piotr Cyganik, Dr. Alan Aspuru‐Guzik, Dr. George M. Whitesides. Charge Tunneling along Short Oligoglycine Chains. Angewandte Chemie International Edition. 2015; 54 (49):14743-14747.

Chicago/Turabian Style

Mostafa Baghbanzadeh; Carleen M. Bowers; Dmitrij Rappoport; Tomasz Żaba; Mathieu Gonidec; Mohammad Al-Sayah; Dr. Piotr Cyganik; Dr. Alan Aspuru‐Guzik; Dr. George M. Whitesides. 2015. "Charge Tunneling along Short Oligoglycine Chains." Angewandte Chemie International Edition 54, no. 49: 14743-14747.