To analyse the clinical features, imaging manifestation, pathological typing and genetic testing results of patients undergoing surgery for ground‐glass opacity (GGO) nodules, and explore the reasonable diagnosis and treatment program for GGO patients as to provide the basis for the establishment of GGO treatment process. This study is an exploratory study. 465 cases with GGO confirmed by HRCT, undergoing surgery and approved by pathologic diagnosis in Shanghai pulmonary hospital were enrolled in this study. All the patients with GGO were cases with single lesion. The relationship between the clinical, imaging, pathological and molecular biological data of single GGO were statistically studied. (1) Among 465 cases, the median age was 58 years and females were 315 (67.7%); there were 397 (85.4%) non‐smoking, and 354 cases (76.1%) had no clinical symptoms. There were 33 cases of benign and 432 cases of malignant GGO. Significant differences were observed on the size, vacuole sign, pleural indentation and blood vessel sign of GGO between two groups (p < 0.05). Of 230 mGGO, there were no AAH, 13 cases of AIS, 25 cases of MIA and 173 cases of invasive adenocarcinoma. The probability of solid nodules in invasive adenocarcinoma was higher than that in micro invasive carcinoma, and the difference was statistically significant (p < 0.05). 360 cases were followed up with the average follow‐up time of 6.05 months, and GGO of 34 cases (9.4%) increased. (2) In 428 adenocarcinoma samples approved by pathologic diagnosis, there were 262 (61.2%) lesions of EGFR mutation, 14 (3.3%) lesions of KRAS mutation, 1 (0.2%) lesion of Braf mutation, 9 (2.1%) lesions of EML4‐ALK gene fusion and 2 (0.5%) lesions of ROS1 fusion. The detection rate of gene mutation in mGGO was higher than that of pGGO. During the follow‐up period, genetic testing results of 32 GGO showed that EGFR mutation rate was 53.1%, ALK positive rate of 6.3%, KRAS mutation rate of 3.1% and no ros1 and BRAF gene mutation. No statistically significant difference was observed in comparison with unchanged GGO. (3) EGFR mutation rate of invasive adenocarcinoma was the highest (168/228, 73.7%), mainly in the 19Del and L858R point mutations. No KRAS mutation was found in atypical adenoma hyperplasia. No significant difference was observed on the mutation rate of KRAS between different types of GGO (p = 0.811). EML4‐ALK fusion gene was mainly detected in invasive adenocarcinoma (7/9). GGO tends to occur in young, non‐smoking women. The size of GGO is related to the degree of malignancy. Pleural depression sign, vacuole sign and vascular cluster sign are all characteristic images of malignant GGO. pGGO and mGGO reflect the pathological development of GGO. During the follow‐up, it is found that GGO increases and solid components appear, which is the indication of surgical resection. The detection rate of EGFR mutations in mGGO and invasive adenocarcinoma is high. pGGO has heterogeneity in imaging, pathology and molecular biology. Heterogeneity research helps to formulate correct individualized diagnosis and treatment plans.

Background: The platelet to high-density lipoprotein cholesterol ratio (PHR) is a novel biomarker for inflammation and hypercoagulability. This study aimed to explore the potential association between PHR and prevalence of chronic obstructive pulmonary disease (COPD). Methods: Participants aged between 40 and 85 years from the 1999– 2018 US National Health and Nutrition Examination Survey with COPD were included. Multivariable logistic regression and restricted cubic spline analysis were applied to evaluate the associations between PHR and COPD. Propensity score matching (PSM) was performed to reduce the impact of potential confounding factors. Results: A total of 25751 participants, including 753 with COPD, at a mean age of 57.19 years and 47.83% men, were included. The multivariable-adjusted model showed that the odds ratio (OR) and 95% confidence interval (CI) for PHR to predict COPD was 1.002 (1.001– 1.003). Compared with the lowest quartile, the ORs and 95% CIs for the Q2, Q3, and Q4 PHR quartile were 1.162 (0.874– 1.546), 1.225 (0.924– 1.625), and 1.510 (1.102– 2.069), respectively (P for trend = 0.012). Restricted cubic spline analysis demonstrated a linear association between PHR and COPD prevalence both before and after PSM. Significant association between PHR and COPD prevalence was observed only in participants without hypertension. Receiver-operating characteristic curves showed significantly higher area under the curve for distinguishing COPD from non-COPD by PHR than platelet count and high-density lipoprotein cholesterol. Conclusion: PHR is significantly associated with COPD prevalence in US adults aged 40 to 85 years without hypertension, supporting the effectiveness of PHR as a potential biomarker for COPD.

High cost and high power consumption of underwater acoustic modem have limited the applications and researches of underwater wireless sensor networks (UWSN). This paper presents a node architecture and its low-cost realization to deal with such problems as high cost, high power consumption, large volume, and relative localization in a dense UWSN. Some fundamental functions like short range underwater acoustic communication, relative range measurement, localization among the nodes are realized. And the experimental results show the nodes can meet the basic requirements of the dense UWSN research.

Probing nanostructures (e.g., nanoelectronics) requires accurate and precise nanopositioning. Furthermore, since measuring I-V data from DC to GHz typically takes more than a minute, little drift is tolerated during the data collection process. This paper reports a closed-loop controlled nanomanipulation system for operation inside a scanning electron microscope (SEM). The system consists of long range coarse positioners and high precision fine positioners. A new position sensing method was developed to achieve nanometer sensing resolution. Closed-loop controller is introduced to control fine. Experimental results demonstrate that the system is capable of automated probing of nanostructures with accuracy better than 3 nm and a drift rate <; 1 nm/min.

This study demonstrates the application of cosmic-ray muography as a non-invasive method for monitoring sediment accumulation and tidal influences in the Shanghai Outer Ring Tunnel, an immersed tube tunnel located beneath the Huangpu River in Shanghai, China. A portable, dual-layer plastic scintillator detector was deployed to conduct muon flux scans along the tunnel’s length and to continuously monitor muon flux, allowing for the study of tidal effects. Geant4 simulations validated the correlation between muon attenuation and overburden thickness, incorporating sediment, water, and concrete layers. Key findings include a strong anti-correlation between the measured muon flux and the water levels observed at a nearby tide gauge. The results align with geotechnical data and simulations, especially in the region of interest, confirming muography’s sensitivity to sediment dynamics. This work establishes muography as a robust tool for long-term, real-time monitoring of submerged infrastructure, offering significant advantages over conventional invasive techniques. The study underscores the potential for integrating muography into civil engineering practices to enhance safety and operational resilience in tidal environments.