Hybrid materials based on magnetic Fe₃O₄ nanoparticles and synthetic macrocyclic receptor, carboxylatopillar[5]arene, have been successfully prepared as a magnetic solid phase extraction (MSPE) adsorbent for the determination of trace pesticides in beverage samples, coupled with high-performance liquid chromatography (HPLC). The effects of various parameters, i.e., the amount of adsorbents, extraction and desorption times, desorption solvent, ionic strength, and sample pH, have been investigated and optimized. The detection limits for seven pesticides are in the range of 5.0–11.3 ng mL⁻¹. The recoveries for all target analytes are over the range of 70.6% to 106.8% with the intra-day and inter-day relative standard deviations less than 7.2% and 8.0%, respectively. The newly developed MSPE-HPLC method has been successfully employed to determine pesticide residues in beverage samples.