Mara Freire

Dr. Mara Freire

University of Aveiro, CICECO
orcid

Research Focus & Metrics

Academic Career Length

23Years (2004-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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2 February 2017 in Chemical Reviews
Verified
Journal Article
Open access
SVSonia P. M. Ventura
Sonia P. M. Ventura
FSFrancisca A. e Silva
Francisca A. e Silva
MQMaria V. Quental
Maria V. Quental
DMDibyendu Mondal
Dibyendu Mondal
Mara FreireMara Freire
Mara Freire
JCJoao Coutinho
Joao Coutinho
Ionic liquids (ILs) have been proposed as promising media for the extraction and separation of bioactive compounds from the most diverse origins. This critical review offers a compilation on the main results achieved by the use of ionic-liquid-based processes in the extraction and separation/purification of a large range of bioactive compounds (including small organic extractable compounds from biomass, lipids, and other hydrophobic compounds, proteins, amino acids, nucleic acids, and pharmaceuticals). ILs have been studied as solvents, cosolvents, cosurfactants, electrolytes, and adjuvants, as well as used in the creation of IL-supported materials for separation purposes. The IL-based processes hitherto reported, such as IL-based solid–liquid extractions, IL-based liquid–liquid extractions, IL-modified materials, and IL-based crystallization approaches, are here reviewed and compared in terms of extraction and separation performance. The key accomplishments and future challenges to the field are discussed, with particular emphasis on the major lacunas found within the IL community dedicated to separation processes and by suggesting some steps to overcome the current limitations.

12 June 2012 in Chemical Society Reviews
Verified
Journal Article
Closed access
PDF file
Mara FreireMara Freire
Mara Freire
ACAna Filipa M. Cláudio
Ana Filipa M. Cláudio
João M. M. AraújoJoão M. M. Araújo
João M. M. Araújo
JCJoao Coutinho
Joao Coutinho
IMIsabel M Marrucho
Isabel M Marrucho
LRLuis Paulo N. Rebelo
Luis Paulo N. Rebelo
During the past decade, ionic-liquid-based Aqueous Biphasic Systems (ABS) have been the focus of a significant amount of research. Based on a compilation and analysis of the data hitherto reported, this critical review provides a judicious assessment of the available literature on the subject. We evaluate the quality of the data and establish the main drawbacks found in the literature. We discuss the main issues which govern the phase behaviour of ionic-liquid-based ABS, and we highlight future challenges to the field. In particular, the effect of the ionic liquid structure and the various types of salting-out agents (inorganic or organic salts, amino acids and carbohydrates) on the phase equilibria of ABS is discussed, as well as the influence of secondary parameters such as temperature and pH. More recent approaches using ionic liquids as additives or as replacements for common salts in polymer-based ABS are also presented and discussed to emphasize the expanding number of aqueous two-phase systems that can actually be obtained. Finally, we address two of the main applications of ionic liquid-based ABS: extraction of biomolecules and other added-value compounds, and their use as alternative approaches for removing and recovering ionic liquids from aqueous media.

14 July 2009 in The Journal of Physical Chemistry A
Verified
Journal Article
Closed access
Mara FreireMara Freire
Mara Freire
Catarina Seiça NevesCatarina Seiça Neves
Catarina Seiça Neves
IMIsabel M Marrucho
Isabel M Marrucho
JCJoao Coutinho
Joao Coutinho
AFAna M. Fernandes
Ana M. Fernandes

2 August 2011 in Chemical Society Reviews
Verified
Journal Article
Closed access
PDF file
Mohammad TariqMohammad Tariq
Mohammad Tariq
Mara FreireMara Freire
Mara Freire
BSBenilde Saramago
Benilde Saramago
JCJoao Coutinho
Joao Coutinho
JLJose Nuno Canongia Lopes
Jose Nuno Canongia Lopes
LRLuis Paulo N. Rebelo
Luis Paulo N. Rebelo
Some of the most active scientific research fronts of the past decade are centered on ionic liquids. These fluids present characteristic surface behavior and distinctive trends of their surface tension versus temperature. One way to explore and understand their unique nature is to study their surface properties. This critical review analyses most of the surface tension data reported between 2001 and 2010 (187 references).

1 October 2007 in Journal of Colloid and Interface Science
Verified
Journal Article
Closed access
Mara FreireMara Freire
Mara Freire
PCPedro J. Carvalho
Pedro J. Carvalho
AFAna M. Fernandes
Ana M. Fernandes
IMIsabel M Marrucho
Isabel M Marrucho
AQAntónio J. Queimada
António J. Queimada
JCJoao Coutinho
Joao Coutinho

24 October 2007 in The Journal of Physical Chemistry B
Verified
Journal Article
Closed access
Mara FreireMara Freire
Mara Freire
Catarina Seiça NevesCatarina Seiça Neves
Catarina Seiça Neves
PCPedro J. Carvalho
Pedro J. Carvalho
Ramesh L. GardasRamesh L. Gardas
Ramesh L. Gardas
AFAna M. Fernandes
Ana M. Fernandes
JCJoao Coutinho
Joao Coutinho