The outbreak of an epidemic disease may pose significant treats to human beings and may further lead to a global crisis. In order to control the spread of an epidemic, the effective management of rapidly increased medical waste through establishing a temporary reverse logistics system is of vital importance. However, no research has been conducted with the focus on the design of an epidemic reverse logistics network for dealing with medical waste during epidemic outbreaks, which, if improperly treated, may accelerate disease spread and pose a significant risk for both medical staffs and patients. Therefore, this paper proposes a novel multi-objective multi-period mixed integer program for reverse logistics network design in epidemic outbreaks, which aims at determining the best locations of temporary facilities and the transportation strategies for effective management of the exponentially increased medical waste within a very short period. The application of the model is illustrated with a case study based on the outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan, China. Even though the uncertainty of the future COVID-19 spread tendency is very high at the time of this research, several general policy recommendations can still be obtained based on computational experiments and quantitative analyses. Among other insights, the results suggest installing temporary incinerators may be an effective solution for managing the tremendous increase of medical waste during the COVID-19 outbreak in Wuhan, but the location selection of these temporary incinerators is of significant importance. Due to the limitation on available data and knowledge at present stage, more real-world information are needed to assess the effectiveness of the current solution.

Reverse logistics network design is a complex decision-making problem that involves the reuse, repair, remanufacturing, and recycling of end-of-life (EOL) under the tradeoff among conflicting objectives. The cutting-edge technologies in Industry 4.0 are now leading to an unprecedented and dynamic transformation of reverse logistics systems, which, however, further complicates the initial network design. In this paper, a two-level decision-support framework combined with both optimization and dynamic simulation is proposed to balance the cost, environmental impact, and service level in smart and sustainable reverse logistics network design under a dynamically evolving and stochastic environment. The results of a real-world case study in Norway show that the method can better support robust strategic decisions, eliminate dominated/near-dominated solutions, and yield holistic performance analyses considering smart reverse logistics transformation. The proposed two-level decision-support framework can better analyze the impact of the technology transformation of Industry 4.0 on reverse logistics systems, while it also provides a fundamental structure for digital reverse logistics twin.