ALEJANDRO MARTINEZ-MARTINEZ

Prof. Dr. ALEJANDRO MARTINEZ-MARTINEZ

Pharmaceutical Sciences, University of Antioquia, Medellín, Antioquia, Colombia
orcid

Research Focus & Metrics

Academic Career Length

34Years (1993-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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14 October 2011 in Marine Drugs
Verified
Journal Article
Open access
PDF file
EJElkin Galeano Jaramillo
Elkin Galeano Jaramillo
Olivier ThomasOlivier Thomas
Olivier Thomas
SRSara Robledo
Sara Robledo
DMDiana Munoz
Diana Munoz
AMALEJANDRO MARTINEZ-MARTINEZ
ALEJANDRO MARTINEZ-MARTINEZ
Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determination of the isolated compounds was performed using one- and two-dimensional NMR, MS and other spectroscopy data. All isolated compounds were screened for their in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compounds 7 and 8 showed selective antiparasitic activity at 10 and 5 µM against Leishmania and Plasmodium parasites, respectively. Cytotoxicity of these compounds on a human promonocytic cell line was also assessed.

1 March 2007 in Journal of Medical Mycology
Verified
Journal Article
Closed access
EJElkin Galeano Jaramillo
Elkin Galeano Jaramillo
AMALEJANDRO MARTINEZ-MARTINEZ
ALEJANDRO MARTINEZ-MARTINEZ

1 January 1997 in Chemical and Pharmaceutical Bulletin
Verified
Journal Article
Closed access
AMALEJANDRO MARTINEZ-MARTINEZ
ALEJANDRO MARTINEZ-MARTINEZ
CDCarmenza Duque
Carmenza Duque
NSNaoko Sato
Naoko Sato
YFYoshinori Fujimoto
Yoshinori Fujimoto

27 February 2013 in Molecules
Verified
Journal Article
Open access
PDF file
JCJhonny Colorado
Jhonny Colorado
DLDiana Muñoz Lasso
Diana Muñoz Lasso
DMDiana Marquez
Diana Marquez
MMMaria Elena Marquez
Maria Elena Marquez
JLJuan Lopez
Juan Lopez
AMALEJANDRO MARTINEZ-MARTINEZ
ALEJANDRO MARTINEZ-MARTINEZ
Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare 30-norlonastane and the sugar residues were identified after acid hydrolysis and GC analyses. Cytotoxicities of the isolated compounds were evaluated against Jurkat and CHO cell lines by a MTT in vitro assay as well as a hemolysis assay. Unexpectedly, all these saponin derivatives showed very low activity in our bioassays.

1 August 1993 in Lipids
Verified
Journal Article
Closed access
PDF file
CDCarmenza Duque
Carmenza Duque
NCNestor Cepeda
Nestor Cepeda
AMALEJANDRO MARTINEZ-MARTINEZ
ALEJANDRO MARTINEZ-MARTINEZ

1 December 2017 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
DEDiana C. Restrepo Espinosa
Diana C. Restrepo Espinosa
YRYony Román
Yony Román
JCJhonny Colorado-Rios
Jhonny Colorado-Rios
ASArquimedes Paixão de Santana-Filho
Arquimedes Paixão de Santana-Filho
GSGuilherme Lanzi Sassaki
Guilherme Lanzi Sassaki
MPMauro Sérgio Gonçalves Pavão
Mauro Sérgio Gonçalves Pavão