Global warming and climate change is one of the most extensively researched and discussed topical issues affecting the environment. Although there are enough historical evidence to support the theory that climate change is a natural phenomenon, many research scientists are widely in agreement that the increase in temperature in the 20th century is anthropologically related. The associated effects are the variability of rainfall and cyclonic patterns that are being observed globally. In Southeast Asia the link between global warming and the seasonal atmospheric flow during the monsoon seasons shows varying degree of fuzziness. This study investigates the impact of climate change on the seasonality of monsoon Asia and its effect on the variability of monsoon rainfall in Southeast Asia. The comparison of decadal variation of precipitation and temperature anomalies before the 1970s found general increases which were mostly varying. But beyond the 1970s, global precipitation anomalous showed increases that almost corresponded with increases in global temperature anomalies for the same period. There are frequent changes and a shift westward of the Indian summer monsoon. Although precipitation is observed to be 70% below normal levels, in some areas the topography affects the intensity of rainfall. These shifting phenomenon of other monsoon season in the region are impacting on the variability of rainfall and the onset of monsoons in Southeast Asia and is predicted to delay for 15 days the onset of the monsoon in the future. The variability of monsoon rainfall in the SEA region is observed to be decadal and the frequency and intensity of intermittent flooding of some areas during the monsoon season have serious consequences on the human, financial, infrastructure and food security of the region

In this study, we evaluated bioinspired titanium dioxide nanoparticles (TiO₂ NPs) that elicited biochemical and proteome modifications in wheat plants under the biotic stress caused by Puccinia striiformis f. sp. tritici (Pst). Biosynthesis of TiO₂ NPs was confirmed using UV–Vis spectrophotometry, energy dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy. We found that the nanoparticles with crystalline nature were smaller than 100 nm. The results of FTIR analysis showed the presence of potential functional groups exhibiting O-H, N-H, C-C, and Ti-O stretching. The TiO₂ NPs of different concentrations (20, 40, 60, and 80 mg L⁻¹) were exogenously applied to wheat plants under the biotic stress caused by Pst, which is responsible for yellow stripe rust disease. The results of the assessment of disease incidence and percent disease index displayed time- and dose-dependent responses. The 40 mg L⁻¹ TiO₂ NPs were the most effective in decreasing disease severity. The bioinspired TiO₂ NPs were also evaluated for enzymatic (superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT)), and nonenzymatic metabolites (total proline, phenolic, and flavonoid contents) in wheat plants under stripe rust stress. The 40 mg L⁻¹ TiO₂ NPs were effective in eliciting biochemical modifications to reduce biotic stress. We further evaluated the effects of TiO₂ NPs through gel- and label-free liquid chromatography-mass spectrometry (LC-MS) proteome analysis. We performed proteome analysis of infected wheat leaves and leaves treated with 40 mg L⁻¹ TiO₂ NPs under stripe rust stress. The functional classification of the proteins showed downregulation of proteins related to protein and carbohydrate metabolism, as well as of photosynthesis in plants under biotic stress. An upregulation of stress-related proteins was observed, including the defense mechanisms and primary metabolic pathways in plants treated with 40 mg L⁻¹ TiO₂ NPs under stress. The experimental results showed the potential of applying biogenic TiO₂ NPs to combat fungal diseases of wheat plants and provided insight into the protein expression of plants in response to biotic stress.