This study reviewed the global prevalence, health and socioeconomic impact, and management approaches of obstructive sleep apnea. The narrative review examined three key dimensions: (1) worldwide OSA prevalence across different regions, accounting for variations in diagnostic standards; (2) OSA’s effects on health outcomes and socioeconomic conditions across diverse populations and healthcare systems; and (3) current global approaches to OSA diagnosis, treatment, and public health management. Despite advances in diagnosis and treatment, a large proportion of OSA cases remain undiagnosed or inadequately managed. The findings show that untreated OSA significantly increases public safety risks, particularly regarding motor vehicle and occupational accidents, while also creating a substantial pool of patients at high risk for systemic complications with severe impacts on overall health. There is a critical need for increased public awareness, universal screening approaches, and integrated care strategies to address this global health challenge and reduce its considerable socioeconomic burden. Our review uniquely addresses global disparities in OSA prevalence, clarifies the health and socioeconomic impacts that remain underexplored in the current literature, and suggests concrete strategies for public health and clinical management improvement worldwide.

Background: Obstructive sleep apnea syndrome (OSAS), affecting approximately 1 billion adults globally, is characterized by recurrent airway obstruction during sleep, leading to oxygen desaturation, elevated carbon dioxide levels, and disrupted sleep architecture. OSAS significantly impacts quality of life and is associated with increased morbidity and mortality, particularly in the cardiovascular and cognitive domains. The cyclic pattern of intermittent hypoxia in OSAS triggers oxidative stress, contributing to cellular damage. This review explores the intricate relationship between OSAS and oxidative stress, shedding light on molecular mechanisms and potential therapeutic interventions. Methods: A comprehensive review spanning from 2000 to 2023 was conducted using the PubMed, Cochrane, and EMBASE databases. Inclusion criteria encompassed English articles focusing on adults or animals and reporting values for oxidative stress and inflammation biomarkers. Results: The review delineates the imbalance between pro-inflammatory and anti-inflammatory factors in OSAS, leading to heightened oxidative stress. Reactive oxygen species biomarkers, nitric oxide, inflammatory cytokines, endothelial dysfunction, and antioxidant defense mechanisms are explored in the context of OSAS. OSAS-related complications include cardiovascular disorders, neurological impairments, metabolic dysfunction, and a potential link to cancer. This review emphasizes the potential of antioxidant therapy as a complementary treatment strategy. Conclusions: Understanding the molecular intricacies of oxidative stress in OSAS is crucial for developing targeted therapeutic interventions. The comprehensive analysis of biomarkers provides insights into the complex interplay between OSAS and systemic complications, offering avenues for future research and therapeutic advancements in this multifaceted sleep disorder.

Eagle syndrome is a rare and poorly understood clinical condition caused by an elongated or disfigured styloid process. The possible managements of Eagle syndrome include conservative medical treatment or surgical intervention. The surgical removal of the elongated styloid process may be efficiently achieved either by an intraoral or a transcervical approach. An effective styloidectomy may be either total or partial, provided the bony residue’s length is within the range of normality. Here, we report our experience with a bilateral robotic-assisted styloidectomy in a young female patient. Our experience showed that this procedure is a safe alternative to traditional surgical approaches, granting an excellent view and a safe manipulation by robotic arms, and, thereby, avoiding iatrogenic damage to neurovascular structures. Moreover, transoral robotic surgery could represent the gold standard for the treatment of bilateral Eagle syndrome cases allowing a quick and safe single-time surgery.

Provided by the Authors: Bowel obstruction is a frequent clinical condition in particular in elderly patients that induce nonspecific intermittent symptoms. Gallstone ileus is a rare form of mechanical bowel obstruction due to biliary calculus stuck into intestinal lumen due to cholecystoduodenal fistula, but also cholecystocolonic, cholecystogastric or left hepatic-duct fistula. Surgery is the treatment of choice, since spontaneous evacuation is uncommon especially when gallstone diameter is higher than 2.5 cm. We report a case of an elderly woman with spontaneous resolution of gallstone ileus secondary to giant stone, and provide a minireview of the available literature

Obstructive Sleep Apnea is a prevalent sleep disorder characterized by repeated episodes of partial or complete upper airway obstruction during sleep, leading to disrupted sleep and associated comorbidities. Effective, traditional diagnostic methods, such as polysomnography, have limitations in providing comprehensive anatomical detail. Recent advancements in imaging technology have the potential to revolutionize the diagnosis and management of OSA, offering detailed insights into airway anatomy, function, and dynamics. This paper explores the latest innovations in imaging modalities, including high-resolution magnetic resonance imaging, functional MRI, three-dimensional airway reconstructions, and the integration of artificial intelligence algorithms for enhanced image analysis. We discuss the potential of these technologies to improve the precision of OSA diagnosis, tailor treatment strategies, and predict treatment outcomes. Moreover, we examine the challenges of implementing these advanced imaging techniques in clinical practice, such as cost, accessibility, and the need for validation in diverse patient populations. We also consider the ethical implications of widespread imaging, particularly regarding data security and patient privacy. The future of OSA management is poised for transformation as these imaging technologies promise to provide a more nuanced understanding of the disorder and facilitate personalized treatment approaches. This paper calls for continued research and collaboration across disciplines to ensure these innovations lead to improved patient care and outcomes in the field of sleep medicine.