A cholesterol-imprinted polymer sorbent and the corresponding reticular control copolymer were synthesized from hydroxyethyl methacrylate and ethyleneglycol dimethacrylate. The sorption isotherms of cholesterol were analyzed using the generalized Langmuir and Freundlich equations. In the case of the imprinted reticular polymer, cholesterol sorption occurred on the energetically homogeneous binding centers, forming one monolayer, while the nonspecific sorption of cholesterol on the control copolymer occurred with energetically nonhomogeneous binding of the sorbate and depended on the physicochemical conditions of sorption.

Polymeric and organo-inorganic sorbents molecularly imprinted with cholesterol were synthesized to create selective hemosorbents for efferent therapy of hypercholesterlemia. These sorbents are block...

Investigation of the effect of the polymer synthesis method on physicochemical properties of sorbents is one of the topical problems in the chemistry of macromolecular compounds that has high scientific and practical interest. Determination of the optimal synthesis method will make it possible to create sorbents with physicochemical properties that led to the realization of effective sorption. In this work, we investigated the effect of synthesis methods (Pickering emulsion polymerization and precipitation polymerization in solution) of granular polymers based on 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate on physicochemical and sorption properties. The synthesis by Pickering emulsion polymerization led to improvement of the n-propyl alcohol diffusion into the polymer network and to the formation of more homogeneous and structurally stable polymer networks. Creating selective polymer networks by Pickering emulsion polymerization compared to precipitation polymerization in solution led to an increase in porosity, creation of more segregated surface of granules, improvement of binding sites availability at the temperature of 37 °C, and formation of the homogeneous sorption surface with high affinity to target molecules at 25 °C and 37 °C. Selective polymers synthesized by both polymerization methods had the largest values of available sorption surfaces areas for target molecules at 37 °C.

An investigation is performed for isotherms of the equilibrium sorption of glucose by surface-imprinted organic-inorganic sorbents based on 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate. It is shown that modifying the copolymer by forming imprint sites reduces the affinity of the sorption surfaces and the monolayer sorption of glucose molecules. In analyzing the match between experimental data obtained under conditions of sorption corresponding to those for the formation of imprint sites and theoretical models of sorption, it is found that introducing 6 mol % glucose molecules as a template produces homogeneous sorption surfaces. The surfaces of organo–inorganic sorbents available for the target sorbent in a liquid–solid system are determined using the Giles classification of experimental sorption isotherms and theoretical models of sorption isotherms.

The bidispersion model is adapted to study the kinetics of the sorption of cholesterol by organo-inorganic molecularly imprinted sorbents and an unimprinted analog of them.