We are interested in how the immune system regulates the delicate balance between protective immunity and immunopathology. Our goal is to combine molecular data with in vivo models to understand the mechanisms underlying homeostatic and pathological conditions and develop effective immunotherapies. Our primary research focuses on understanding the biology of lymphotoxin (LT) and TNF cytokines. Over the last 20 years, we have developed mouse models with targeted disruption of LT and TNF pathways, which serve as valuable tools for dissecting the mechanisms underlying both homeostatic and pathological conditions. Our ongoing studies focus on the role of LT signaling in regulating pain responses, mucosal immunity, lymphoid organ homeostasis, and cancer immunotherapy.