The coronavirus pandemic has resulted in major disruptions in the way municipal solid waste management systems (MSWMSs) operate due to substantial distortions in waste generation trends, along with a variety of significant operational and managerial challenges. As critical infrastructure, MSWMSs have endeavored to adapt in response to such unprecedented stresses in order to maintain their operations during the pandemic. The challenges and their relevant adaptive measures, however, have varied with the progression of the pandemic across different MSWMSs. Currently, there is a limited understanding of such time-bound and system-specific phenomena, which impedes timely and effective adaptation. This study aims to fill this knowledge gap by performing a detailed and documented investigation of the longitudinal impact of the coronavirus pandemic on different MSWMSs across the United States, along with its evolution over time, using collected qualitative and quantitative data (i.e., monthly interviews with waste management personnel, online news media, and waste tonnages). This study also develops a relational database system to facilitate the systematic recording and monitoring of the pandemic’s impact on MSWMSs, as well as guide the implementation of different adaptation strategies based on distinct systems’ characteristics. Findings of this study will help solid waste decision-makers better understand the current pandemic, along with serving as a knowledge base for future pandemic scenarios towards more resilient MSWMSs.