I have extensive experience in research on the role of Presenilin-1(PS1)/γ-secretase system on the function of various cell systems including neuronal and endothelial cells. I have been working exclusively on the molecular biology of WT and mutant PS1 for over 28 years. I was the first to show that PS1 localizes at Cadherin-based adherens junctions at cell-cell contact sides and synapses. In addition, I found the interaction of PS1 with substrates of γ-secretase such as E- and N-cadherins and ephinB ligands and EphB receptors and the physiological role that these interactions have. I am currently Research Professor at the Center for Molecular Biology and Genetics of Neurodegeneration, department of Psychiatry at the Icahn School of Medicine at Mount Sinai. My laboratory studies mechanisms of VEGF/VEGFR2 and ephrinB/EphB-mediated angiogenesis and neuroprotection and the role that PS1/γ-secretase system may have on their regulation aiming to discover methods to effectively treat and prevent neurodegenerative disorders like AD.