The basic idea from which the working hypothesis for this study started is the fact that the only systemic disease today that is clearly linked to periodontal disease by biochemical mechanisms is diabetes mellitus, as well as the clinical finding that diabetes causes a number of specific periodontal changes. Highlighting the biochemical markers of inflammation during periodontal disease in patients diagnosed with type 2 diabetes is the main aim of the study. To achieve this objective, we used the human ELISA kit from Boster Biological Technology Co., Ltd. (Pleasanton, CA, USA), for the detection of IL-1β, IL-4, IL-8 and TNF-α. The data analysis shows that plasma levels of these cytokines are associated with the progression of periodontitis. In conclusion, we can state that the involvement of immunological markers is evident in the pathogenesis of periodontal disease.

Introduction: Diabetes mellitus negatively influences oral health, significantly contributing to the worsening of odonto-periodontal pathology. Accurate diagnosis and monitoring of lesions are essential to prevent complications. CBCT (cone beam computed tomography) provides a detailed image of bone structures, being a valuable tool in this context. Materials and methods: Thisprospective observational comparative study included 120 patients with chronic periodontitis, divided into two equal groups: 60 with type 2 diabetes mellitus and 60 without systemic diseases. All were examined clinically and radiologically using high-resolution CBCT. Results: Diabetic patients presented a significantly higher mean bone loss (4.7 mm) compared to the non-diabetic patients (3.0 mm). Periodontal pockets >5 mm were more frequent in the diabetic group (75% vs. 50%). CBCT revealed vertical defects and extensive periapical lesions especially in patients with diabetes. Three-dimensional imaging allowed for detailed assessment and clear differentiation between the severity of cases. Conclusions: CBCT is essential in the early identification and evaluation of periodontal disease in diabetic patients. The use of this method significantly contributes to the correlation of clinical and imaging data, optimizing the diagnosis and treatment plan.

The present research attempts to assess the general health status of the studied group of patients by applying the questionnaire method. The research group has been composed of 210 subjects, from both urban and rural areas, having periodontal pathologies and disorders of the glucidic metabolism. In order to obtain information about the general health condition as well as the orodental hygiene, we have applied the questionnaire method, this being well individualized and adapted to be relevant to the present study. It was highlighted that patients with odonto-periodontal pathology and diabetes gave a more affected general health compared to those without diabetes.

The present research attempts to assess the orodental health status of patients in the research group. The research group has been composed of 210 subjects, from both urban and rural areas, having periodontal pathologies and disorders of the glucidic metabolism. In order to obtain information about the orodental health condition as well as the orodental hygiene, we have applied the questionnaire method, this being well individualized and adapted to be relevant to the present study. Following the statistical analysis of the results, it appears that the subjects of the research group show a more pronounced periodontal pathology comparative to the control group. The study results highlight the importance of dentists’ knowledge of diagnostic techniques, treatment and prevention of orodental pathologies on patients with diabetes.