Antonio Marchetti is Professor of Pathology at the “G. d’Annunzio” University of Chieti-Pescara, Italy, and Group Leader at the Center for Advanced Studies and Technology (CAST). His research has focused on the molecular pathology of cancer, from experimental tumorigenesis to oncogenomics, molecular diagnostics, and precision oncology. During his research at the National Cancer Institute, NIH, Bethesda, he was first author of the study that identified and cloned Int6, now known as EIF3E, as a novel common integration site for mouse mammary tumor virus in mammary preneoplasia and tumors, and co-inventor of the related U.S. patent on the nucleotide and deduced amino acid sequences of Int6. He subsequently contributed to the characterization of human EIF3E and investigated its expression and biological significance in human cancer. His current research focuses on rare genomic alterations and gene fusions in solid tumors and on the clinical implementation of advanced molecular diagnostic approaches, including next-generation sequencing.