Salmonella is a major bacterial pathogen in low-income countries, where it circulates among humans, animals, and the environment. Children with sickle cell disease (SCD) are particularly vulnerable to severe Salmonella infections. This study aimed to characterize Salmonella isolates causing infections in Senegalese children with SCD. Using antimicrobial susceptibility testing, whole-genome sequencing, and bioinformatic analysis, we investigated antibiotic resistance, serovar diversity, and virulence factors on 23 isolates from SCD patients with diverse clinical infections. The isolates belonged to 12 serovars, with Enteritidis predominating (n = 7). Twenty-two isolates were fully susceptible to antibiotics, while one was multidrug-resistant. Eight isolates (Enteritidis and Typhimurium) carried a virulence plasmid harboring the spvRABCD gene cluster. Core Salmonella pathogenicity islands (SPIs-1 to -5, -11, and -13), as well as SPI-10 and SPI-23, were detected in all isolates, whereas other SPIs were variably present. These results show high serovar diversity and low antimicrobial resistance among Salmonella isolates in children with SCD in Dakar, Senegal. Our findings suggest that strains causing diarrhea in healthy individuals may also cause invasive disease in SCD patients, highlighting the need for dedicated surveillance in this vulnerable population.

L’objectif de cette étude était de répertorier, les espèces de monogènes du genre Lamellodiscus parasites des poissons sparidés du genre Dentex des côtes sénégalaises de décembre 2019 à Aout 2021. Les sparidés sont des poissons d’intérêts commercial et aquacole et les monogènes constituent un potentiel danger sur leur santé et leur productivité en milieu confiné. Les poissons Dentex angolensis, D. canariensis, D. macrophthalmus et D. maroccanus ont été collectés au niveau des sites de débarquement de Soumbédioune et Hann Bel-Air, localités de la région de Dakar. L’analyse des critères morpho-anatomiques des pièces sclérifiées du hapteur des monogènes, ainsi que les mensurations ont permis de mettre en évidence la présence de sept (7) espèces de Lamellodiscus. Dentex canariensis hébergeait le plus grand nombre de parasites dans les localités d’échantillonnage. L’intensité et l’abondance des parasites étaient plus élevées pendant la saison chaude (I = 11,35 ; A = 10,57). Quant aux poissons, les spécimens de petite taille (14 à 18 cm) étaient majoritairement infestés. Cette étude a révélé une prévalence globale des Lamellodiscus parasites du genre Dentex de 57,18%. Ainsi, une meilleure compréhension de la biologie de ces parasites serait indispensable pour toute tentative de domestication de ces poissons. The objective of this study was to inventorise the species of monopisthocotylans belonging to Lamellodiscus parasitizing sparid fishes of the genus Dentex along the Senegalese coast from December 2019 to August 2021. Sparids are fishes of interest to commercial fisheries and aquaculture. Monogeneans pose a potential threat to their health and productivity in confined environments. The fish species Dentex angolensis, D. canariensis, D. macrophthalmus, and D. maroccanus were collected from the landing sites in Dakar. Our analysis of the morpho-anatomical characteristics of the sclerotized parts of the monogenean haptor, along with measurements, revealed the presence of seven species of Lamellodiscus. The host species Dentex canariensis harboured the highest number of parasites at the sampling sites. Parasite intensity and abundance were higher during the warm season (I = 11.35; A = 10.57). As for the fish, smaller specimens (14–18 cm) were predominantly infested. This study revealed an overall prevalence of species of Lamellodiscus in species of Dentex of 57.18%. Thus, a better understanding of the biology of these parasites is essential for any attempt to domesticate these fish.