One of the most serious/potentially fatal complications of transsphenoidal surgery (TSS) is internal carotid artery (ICA) injury. Of 6230 patients who underwent TSS, ICA injury occurred in 8 (0.12%). The etiology, possible treatment options, and avoidance of ICA injury were analyzed. ICA injury occurred at two different stages: (1) during the exposure of the sella floor and dural incision over the sella and cavernous sinus and (2) during the resection of the cavernous sinus extension of the tumor. The angiographic collateral blood supply was categorized as good, sufficient, and nonsufficient to help with the decision making for repairing the injury. ICA occlusion with a balloon was performed at the injury site in two cases, microcoils in two patients, microcoils plus a single barrel extra-intracranial high-flow bypass in one case, stent grafting in one case, and no intervention in two cases. The risk of ICA injury diminishes with better preoperative preparation, intraoperative navigation, and ultrasound dopplerography. Reconstructive surgery for closing the defect and restoring the blood flow to the artery should be assessed depending on the site of the injury and the anatomical features of the ICA.

Tment of the disease. However, in the absence of remission or recurrence of hypercortisolism after neurosurgical resection (adenomectomy), as well as in cases when surgical intervention cannot be carried due to medical contraindications to surgical intervention, radiation treatment is used as an alternative or adjoining therapy. In this literature review the efficiency of different radiation techniques (the conventional and the modern techniques), as well as possible complications of modern methods of radiosurgery and radiotherapy have been looked for....

Itsenko-Cushing’s disease is a severe neuroendocrine disease caused by chronic hyperproduction of adrenocorticotropic hormone by a corticotrophic pituitary tumor (corticotropinoma). Surgical tumor resection remains the gold standard in the treatment of Itsenko-Cushing’s disease and leads to remission in 65–95 % of cases. Despite the benign nature of the disease, even in specialized neurosurgical centers, the recurrence rate of the disease is 25–35 % of cases. This paper presents an analysis of the effectiveness of various options for endoscopic transnasal removal of corticotropinomas, the selection of which was based on the topographic and anatomical features of the tumors. It was found that each of the surgical treatment options provides comparable results in achieving remission (from 81,3 to 87,9 %), while the most optimal method of surgical treatment in terms of recurrence-free survival and postoperative endocrine disorders is partial hypophysectomy, which will increase the likelihood of long-term remission of the disease.

The issue of total removal of giant pituitary adenomas remains relevant, despite all existing methods of surgical treatment. The use of a combination of transcranial approaches can increase the radicality and reduce the number of postoperative complications in the surgery of these tumors. In the practice of the N. N. Burdenko National Medical Research Center for Neurosurgery, a unique, previously not described experience of using this technique in 33 patients has been accumulated. There are no publications in the world scientific literature devoted to the analysis of the results of surgical treatment of patients with GPA operated on with combined transcranial approaches. In the presented work, the most relevant classifications related to giant pituitary adenomas are collected; the technique of performing combined transcranial approaches and the prospects for its study are indicated.

Journal for Research in Applied Sciences and Biotechnology (JRASB) runs under Stallion Publication. It is an Online, Double-Blind, Peer-Reviewed and Bi-Monthly Journal, focusing on theories, methods and applications in all the fields of Applied Sciences and Biotechnology subjects. Papers for publication are selected through peer review to ensure originality, relevance, and readability. The journal ensures a wide indexing policy to make published papers highly visible to the related community.

Journal for Research in Applied Sciences and Biotechnology (JRASB) runs under Stallion Publication. It is an Online, Double-Blind, Peer-Reviewed and Bi-Monthly Journal, focusing on theories, methods and applications in all the fields of Applied Sciences and Biotechnology subjects. Papers for publication are selected through peer review to ensure originality, relevance, and readability. The journal ensures a wide indexing policy to make published papers highly visible to the related community.