Currently, we are working on the pathological role of endothelial cells during pulmonary arterial hypertension development. Specifically, we utilize the transgenic mice and MCT or SuHx Rat model to interpret the underlying mechanism of FABP4/5, CDK19, TMEM100 and TMEM173 targeted endothelial cells in the process of PAH. Additionally, we are working on the single-cell profiles of endothelial cells from established mouse models and clinical pulmonary arterial hypertension patients, which will provide effective theoretical evidence for individualized treatment.