Bala Addepalli is an Analytical Biochemist with broad research interests in analytical chemistry, biochemistry, molecular biology, mass spectrometry (MS)-based characterization and structural determination of proteins, nucleic acids, and their modifications. He described the type and nature of viral nucleic acids along with their protein-coding potential during his Ph.D. studies. His postdoctoral studies with Prof. Arthur Hunt had identified the existence of novel RNA processing endonuclease in plant polyadenylation apparatus. His studies have also unraveled the molecular characteristics of plant poly(A) polymerases and interactions with other key polyadenylation subunit factors. He joined with Prof. Patrick Limbach to develop mass spectrometry (MS)-based approaches for sample preparation, detection, and quantification of mass-silent nucleoside modification, pseudouridine, and other posttranscriptional modifications in RNA. He was inducted into the faculty as Assistant Professor-Research at the Department of Chemistry in August 2013 and was promoted to Associate Professor in August 2018 at University of Cincinnati. The current research program includes development of novel ribonucleases for RNA modification mapping, improved characterization of nucleoside modifications (both enzymatic and xenobiotic stress-induced) and understanding the effect of xenobiotic stress (including organic pollutants, radiation) at the level of cellular translation during gene expression process.