Benedetta Bedetti

Dr. Benedetta Bedetti

Helios Klinikum Bonn/Rhein-Sieg, Bonn, North Rhine-Westphalia, Germany
orcid

Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 May 2019 in European Journal of Cardio-Thoracic Surgery
Verified
Journal Article
Closed access
Luca BertolacciniLuca Bertolaccini
Luca Bertolaccini
HBHasan Batirel
Hasan Batirel
ABAlessandro Brunelli
Alessandro Brunelli
DGDiego Gonzalez-Rivas
Diego Gonzalez-Rivas
MIMahmoud Ismail
Mahmoud Ismail
Gaetano RoccoGaetano Rocco
Gaetano Rocco
OBJECTIVES: Our goal was to report the results of the first consensus paper among international experts in uniportal video-assisted thoracoscopic surgery (UniVATS) lobectomy obtained through a Delphi process, the objective of which was to define and standardize the main procedural steps, optimize its indications and perioperative management and identify elements to assist in future training. METHODS: The 40 members of the working group were convened and organized on a voluntary basis by the Uniportal VATS Interest Group (UVIG) of the European Society of Thoracic Surgeons (ESTS). An e-consensus finding exercise using the Delphi method was applied to require 75% agreement for reaching consensus on each question. Repeated iterations of anonymous voting continued for 3 rounds. RESULTS: Overall, 31 international experts from 18 countries completed all 3 rounds of questionnaires. Although a technical quorum was not achieved, most of the responders agreed that the maximum size of a UniVATS incision should be ≤4 cm. Agreement was reached on many points outlining the currently accepted definition of a UniVATS lobectomy, its indications and contraindications, perioperative clinical management and recommendations for training and future research directions. CONCLUSIONS: The UVIG Consensus Report stated that UniVATS offers a valid alternative to standard VATS techniques. Only longer follow-up and randomized controlled studies will predict whether UniVATS represents a valid alternative approach to multiport VATS for major lung resections or whether it should be performed only in selected cases and by selected centres. The next step for the ESTS UVIG is the establishment of a UniVATS section inside the ESTS databases.

1 June 2017 in Journal of Thoracic Disease
Verified
Journal Article
Closed access
PDF file
BBBenedetta Bedetti
Benedetta Bedetti
Luca BertolacciniLuca Bertolaccini
Luca Bertolaccini
RRRaffaele Rocco
Raffaele Rocco
JSJoachim Schmidt
Joachim Schmidt
PSPiergiorgio Solli
Piergiorgio Solli
MSMarco Scarci
Marco Scarci
Background: In recent years, many factors have revamped the interest in segmentectomies as preferred procedure for stage I non-small cell lung cancer (NSCLC). The aim of this systematic review and meta-analysis is to compare the outcomes of segmentectomy versus lobectomy regarding overall survival (OS) in the surgical treatment of stage I NSCLC, as stated in the conclusions of the largest studies conducted in this field and reported to date. Methods: The searching strategy was developed in EMBASE, MEDLINE and Cochrane CENTRAL from 1990 until December 2016. The meta-analysis was performed with the combination of the reported survival outcomes of the individual studies using a random effect model. The OS of the lobectomy group was compared with the segmentectomy group alone. The hazard ratio (HR) and standard error were extracted or calculated for each study using the Kaplan-Meier method. Results: Regarding the results, most of these studies were based on the retrospective data. The size of the cohorts varied from 17 to 11,520, with a total number of 24,542 patients. The pooled HR was 1.04 [95% confidence interval (CI), 0.92–1.18; P=0.50]. Conclusions: The survival in the segmentectomy group was not inferior to patients treated with lobectomy. In conclusion, the current meta-analysis disclosed that segmentectomies produce similar survival compared to lobectomy for patients with stage I NSCLC. To establish the role of segmentectomy in early NSCLC, more evidence is needed, in particular, a large numbered, prospective, randomised trials, which should dissolve the uncertainties and the questions raised by retrospective data.

24 June 2015 in Annals of Surgical Oncology
Verified
Journal Article
Closed access
PDF file
BBBenedetta Bedetti
Benedetta Bedetti
KWKarsten Wiebe
Karsten Wiebe
ARAndreas Ranft
Andreas Ranft
HAHermann Aebert
Hermann Aebert
JSJoachim Schmidt
Joachim Schmidt
Uta DirksenUta Dirksen
Uta Dirksen

1 January 2017 in Journal of Thoracic Disease
Verified
Journal Article
Closed access
PDF file
BBBenedetta Bedetti
Benedetta Bedetti
Luca BertolacciniLuca Bertolaccini
Luca Bertolaccini
PSPiergiorgio Solli
Piergiorgio Solli
MSMarco Scarci
Marco Scarci
Background: Uniportal video-assisted thoracoscopy (VATS) has increasingly gained importance in the thoracic surgery scenario. The use of this technique can reduce postoperative pain and length of stay and gives the surgeon the same operative perspective as open surgery. Methods: We retrospectively analysed the data of 73 patients who underwent uniportal VATS lobectomies from November 2014 to December 2015 in our institution. We divided the patients in two groups (group 1: first 30 patients vs. group 2: established phase, 43 patients) to compare and evaluate the data regarding the learning curve. To explore evolution of learning curve, data were plotted to calculate Spearman’s Rank-Order Correlation. R (version 3.2.3) was used for statistical analysis. Results: The median age was 69.9 (group 1) and 68.8 (group 2) years. Mean operative time was 84.9±33.0 (group 1) and 84.8±31.5 (group 2) minutes. The conversion rate was 13.3% in group 1 vs. 9.3% in group 2, showing a significant learning reduction (rho=0.590). Overall morbidity rate was 15.1%. The most common complication consisted in prolonged air leak. Interpolation line of complications showed a significant decrease due to learning curve (rho=0.676). The median length of stay was 4 days in group 1 vs. 3 days in group 2. The 30-day mortality was 3.3% in group 1 and 0% in group 2. Conclusions: The comparison between the groups showed that the median length of stay, operative time, conversion rate and 30-day mortality statistically significantly improved in the established phase. Also, complications like prolonged air leak were decreasing in the established phase. In conclusion, the uniportal VATS lobectomy technique can be performed safely from experienced surgeons without major complications and with an acceptable mortality rate.

1 February 2016
Verified
Journal Article
Open access
PDF file
MSMarco Scarci
Marco Scarci
PSPiergiorgio Solli
Piergiorgio Solli
BBBenedetta Bedetti
Benedetta Bedetti
Enhanced recovery pathway for thoracic surgery in the UK

4 May 2017 in Journal of Visualized Surgery
Verified
Journal Article
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BBBenedetta Bedetti
Benedetta Bedetti
Philipp SchnorrPhilipp Schnorr
Philipp Schnorr
JSJoachim Schmidt
Joachim Schmidt
MSMarco Scarci
Marco Scarci
During the last three decades, minimally invasive surgery has become common practice in all kinds of surgical disciplines and, in Thoracic Surgery, the minimally invasive approach is recommended as the treatment of choice for early-stage non-small cell lung cancer. Nevertheless, all over the world a large number of lobectomies is still performed by conventional open thoracotomy and not as video-assisted thoracic surgery (VATS), which shows the need of a proper training for this technique. Development and improvement of surgical skills are not only challenging and time-consuming components of the training curriculum for resident or fellow surgeons, but also for more experienced consultants learning new techniques. The rapid evolution of medical technologies like VATS or robotic surgery requires an evolution of the existing educational models to improve cognitive and procedural skills before reaching the operating room in order to increase patient safety. Nowadays, in the Thoracic Surgery field, there is a wide range of simulation-based training methods for surgeons starting or wanting to improve their learning curve in VATS. Aim is to overcome the learning curve required to successfully master this new technique in a brief time. In general, the basic difference between the various learning techniques is the distinction between “dry” and “wet” lab modules, which mainly reflects the use of synthetic or animal-model-based materials. Wet lab trainings can be further sub-divided into in vivo modules, where living anaesthetized animals are used, and ex vivo modules, where only animal tissues serve as basis of the simulation-based training method. In the literature, the role of wet lab in Thoracic Surgery is still debated.