Dr. Changye Hui, Deputy Director of the Institute of Pathology and Toxicology at Shenzhen Prevention and Treatment Center for Occupational Diseases, earned his M.D. from Southern Medical University in 2010. Confronted with the mounting threat of heavy-metal pollution, he leads an interdisciplinary team that rationally rewires microbial resistance pathways against Pb, Cd, Hg, As, and Sb and organic contaminants. Pioneering the concept “pollutant exposure → pigment synthesis → naked-eye qualitative read-out → visible-light colorimetric quantification”, his group delivers robust whole-cell biosensors for on-site detection of heavy metals and organophosphates in environmental water and human specimens. Beyond sensing, his engineered microbes are exploited for whole-cell biosorption and bio-detoxification, offering sustainable bioremediation solutions. Since 2018, he has published 36 corresponding-author papers in Journal of Hazardous Materials, Biosensors & Bioelectronics, Water Research, and other premier journals.