In this study, an alternative methodology for the aqueous synthesis of chalcones is presented. This methodology is ecologically sound, since it occurs at room temperature and utilizes only KOH (a green base). In addition, it showed a broad applicability, as evidenced by the preparation of 37 derivatives in good to excellent yields (up to 98%). Moreover, most compounds were recovered pure enough through straightforward fil-tration and water washing. The development of the reaction is accompanied by a study that demonstrates that the yield of the products and the reaction mechanism are directly affected by the solubility and physical state of the starting materials.

In this study, an alternative methodology for the aqueous synthesis of chalcones is presented. This procedure is performed on a green basis at room temperature (25–40 °C) and using KOH. From this method, thirty-seven derivatives were obtained with yields of up to 98%. In addition, many compounds were recovered sufficiently pure by direct filtration and washing with water. The manuscript is accompanied by a study that demonstrates that the yield of the products and the reaction mechanism, which occurs on-water and in-water, are directly affected by the solubility and physical state of the starting materials.