This study shows the benefits of using the environmental product declarations (EPDs), based on ISO 14025:2013, for the configuration and conceptualization of new building materials. Using a quantitative evaluation on these phases of design, it allows one to create materials with lower impacts, in comparison with the existing ones. In this paper, it is proposed to evaluate the potentiality of this tool in the development of a panel from pineapple by-products from agroindustry, used as a thermal insulator. The issue of environmental sustainability was pursued, employing the assessment of the environmental impacts according to characterization methods defined by the International EPD^® System. By comparing the possible compositions of the materials under development, with certified environmental declarations of commercial materials, it is possible to identify and select optimal compositions decreasing up to 98.28% of impacts in acidification potential or up to 99.38% for photochemical oxidation—with respect to traditional materials—already at the design stage, where the changes on the composition or the facilities decision have fewer complications.