Ms. Daria Duca
European Institute of Oncology
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Academic Career Length
6Years (2021-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
The Human Papillomavirus (HPV) is the causative agent of different kinds of tumors, including cervical cancers, non-melanoma skin cancers, anogenital cancers, and head and neck cancers. Despite the vaccination campaigns implemented over the last decades, we are far from eradicating HPV-driven malignancies. Moreover, the lack of targeted therapies to tackle HPV-related tumors exacerbates this problem. Biomarkers for early detection of the pathology and more tailored therapeutic approaches are needed, and a complete understanding of HPV-driven tumorigenesis is essential to reach this goal. In this review, we overview the molecular pathways implicated in HPV infection and carcinogenesis, emphasizing the potential targets for new therapeutic strategies as well as new biomarkers.
About Me
In July 2022 I will graduate from the The University of Aberdeen, with a Degree of Bachelor of Science (Honours) in Immunology at, Scotland.
During the second year of my degree (2018) I had the opportunity to undertake an exchange semester at the University of Guelph, Canada which focused on biomedical sciences and genetics.
The strong interest for oncology lead me to pursue a Degree of Master in Science in Immunology at the European Institute of Oncology (IEO) in Milan, Italy, which I will leave inJune 2022. During the 2 years spent at IEO I carried out my main thesis project involving the use of CRISPR/Cas9 in HPV-positive head and neck cancer cells lines in order to silence E6 and E7 oncoviral proteins. I also completed a second thesis describing the initial stage of a study aimed at integrating transcriptomic profiles with genetic and molecular signatures to
determine differences between responsive and non-responsive laryngeal and
hypopharyngeal cancer patients.