Rapeseed meal (RSM) is a by-product of rapeseed oil extraction and is a rich source of bioactive compounds, including proteins and antioxidants. This study compared two methods for extracting antioxidants from RSM: conventional ethanol Soxhlet extraction and supercritical CO₂ extraction. These procedures were applied to both native RSM and RSM after protein removal to evaluate their bio-compound composition and potential applications. HPLC-DAD, NMR, and GC/MS analyses revealed a rich polyphenolic profile in the extracts, including the presence of sinapic acid. The concentration of sinapic acid varied depending on the extraction method used. The anti-radical activity of the extracts was also analysed using the DPPH assay, which confirmed the potential of RSM as a source of antioxidants for use in cosmetics, food, and pharmaceutical formulations.

A Pd-catalyzed, simple, and efficient approach toward structurally diverse fused polycyclic [1,2,3]triazolo[4,5-c]quinoline and 4,5-dihydro-[1,2,3]triazolo[4,5-c]quinoline has been developed. The method is based on intramolecular Pd-catalyzed C–H activation and features operational simplicity, high atom economy, broad substrate scope, excellent yields, and good functional group tolerance. Gram-scale experiments and post-synthetic modifications were performed to extend the synthetic applicability of the proposed methodology and enhance the structural complexity of the obtained derivatives.

Over the past two decades, the copper(I)-catalyzed azide–alkyne 1,3-dipolar cycloaddition (CuAAC), commonly known as click chemistry, and C–H bond activation have gained significant attention and have emerged as key synthetic methodologies. In our efforts to synthesize fused nitrogen-containing heterocycles, we developed a palladium-catalyzed protocol for the synthesis of functionalized 7,10-dihydropyrrolo[3,2,1-ij][1,2,3]triazolo[4,5-c]quinolines and 5,8-dihydrobenzo[3,4][1,2,3]triazolo[4′,5′:5,6]azepino[1,2-a]indoles from suitable bromo-substituted N-propargyl-indoles. The reaction conditions demonstrate broad functional group compatibility including halogen, alkoxyl, cyano, ketone, and ester, affording the target compounds in good to high yields.

Tryptophan derivatives are valuable non‐canonical amino acids widely used as precursors for the synthesis of bioactive molecules, as biophysical probes or introduced into polypeptides to improve or create entirely new functions. The enzyme tryptophan synthase (TrpS) provides a sustainable biocatalytic route to access these compounds directly from substituted indoles and l ‐serine. In this work, the substrate scope of Salmonella enterica tryptophan synthase (SeTrpS) was probed using a diverse library of synthetic indole derivatives bearing aryl, N ‐methylamino, alkynyl, and halogen substituents. Notably, SeTrpS displayed moderate to high conversions for most of the indoles tested, particularly for those substituted at positions 6 and 7. Two representative preparative scale reactions demonstrated the scalability of the process, affording the corresponding l ‐7‐ethynyltryptophan and l ‐5‐phenyltryptophan analogues in 58% and 25% yield, respectively, and excellent purity. This study contributes to illustrate the versatility of SeTrpS as a biocatalyst for the efficient and sustainable synthesis of structurally diverse tryptophan analogues, expanding the known substrate tolerance of this enzyme.

The gold-catalyzed cyclization of 2,2-bis(3-arylprop-2-yn1-yl)malonic acid has been proposed as an efficient approach to substituted 3,8-dibenzyl-2,7-dioxaspiro[4.4]nonane-1,6-diones. The reaction proceeds smoothly in mild reaction conditions to give the desired products in quantitative yields in the presence of variously substituted starting materials. In addition, the synthesis of γ-arylidene spirobislactone bearing different substituents on the two aromatic rings has been achieved. This kind of compound could be of great interest in pharmaceutical science given the widespread presence of this scaffold in bioactive natural and synthetic products.