In Digital Literacy 5.0, the intersectionality of digital competence across various domains marks a paradigm shift from traditional siloed approaches to a more integrated and holistic framework. This article explores the pervasive influence of digital literacy across diverse fields including health, medicine, nutrition, medical tourism, economy, biomedical sciences, bioinformatics, telemedicine, telehealth, artificial intelligence (AI), and vascular surgery. Emphasizing the necessity of digital literacy not just as a skill for tool utilization but as a cornerstone for understanding and leveraging the potential of digital technologies, this comprehensive exploration underscores the critical role of digital competence in enhancing patient outcomes, driving economic growth, spurring innovation, and revolutionizing healthcare and surgical practices. Through a multidisciplinary lens, the article elucidates the indispensability of digital literacy in a technologically interconnected era, highlighting its implications for policy, educational paradigms, and future technological advancements.

Hereditary anemia has various manifestations, such as sickle cell disease (SCD), Fanconi anemia, glucose-6-phosphate dehydrogenase deficiency (G6PDD), and thalassemia. The available management strategies for these disorders are still unsatisfactory and do not eliminate the main causes. As genetic aberrations are the main causes of all forms of hereditary anemia, the optimal approach involves repairing the defective gene, possibly through the transplantation of normal hematopoietic stem cells (HSCs) from a normal matching donor or through gene therapy approaches (either in vivo or ex vivo) to correct the patient’s HSCs. To clearly illustrate the importance of cell and gene therapy in hereditary anemia, this paper provides a review of the genetic aberration, epidemiology, clinical features, current management, and cell and gene therapy endeavors related to SCD, thalassemia, Fanconi anemia, and G6PDD. Moreover, we expound the future research direction of HSC derivation from induced pluripotent stem cells (iPSCs), strategies to edit HSCs, gene therapy risk mitigation, and their clinical perspectives. In conclusion, gene-corrected hematopoietic stem cell transplantation has promising outcomes for SCD, Fanconi anemia, and thalassemia, and it may overcome the limitation of the source of allogenic bone marrow transplantation.

Globally, breast cancer is one of the most prevalent diseases, inducing critical intimidation to human health. Lipid-based nanomaterials have been successfully demonstrated as drug carriers for breast cancer treatment. To date, the development of a better drug delivery system based on lipid nanomaterials is still urgent to make the treatment and diagnosis easily accessible to breast cancer patients. In a drug delivery system, lipid nanomaterials have revealed distinctive features, including high biocompatibility and efficient drug delivery. Specifically, a targeted drug delivery system based on lipid nanomaterials has inherited the advantage of optimum dosage and low side effects. In this review, insights on currently used potential lipid-based nanomaterials are collected and introduced. The review sheds light on conjugation, targeting, diagnosis, treatment, and clinical significance of lipid-based nanomaterials to treat breast cancer. Furthermore, a brighter side of lipid-based nanomaterials as future potential drug delivery systems for breast cancer therapy is discussed.

Communication in the digital age has been transformed into more complicated ways due to various mediums and platforms based on information technology and digital devices. The digital age has brought about complex changes to communication through the use of technology and digital devices. It has more threats as well as benefits and innovations. In the meantime, many people who engaged in communication don’t fully take advantages but fall into miscommunication due to lack of digital literacy. In particular, in the field of health services, the threats of digital communication would make people, for instances the patients, in danger. While it offers benefits and innovations, it also brings new threats, particularly in the field of healthcare where miscommunication can harm patients mentally and physically. The miscommunication, misunderstanding etc. would harm their health mentally and physically. To address these issues, it is crucial to explore and analyze communication from multiple perspectives using scientific approaches. Hence, thinking and research on communication is extremely important. Various scientific approaches should be applied to analyze and sharpen communication in multiple perspectives. This manuscript discusses soft-skills of communication in the field of health issues of the digital era. This study is an attempt to invent the theoretical foundation of the ways in communication throughout analytical and philosophical approaches. It is Neurophilocommunication (NPC) that comprise of thoughts in communication that could be applied in the field of health issues on digital base and platforms.This study proposes NPC, a concept combining communication and neuroscience to enhance communication in healthcare in the digital era. The goal is to establish a theoretical foundation for effective communication and to improve the health outcomes of patients.

Looking at the times, humanitarian problems have developed so complex, ranging from genetics, space exploration, education, interfaith relations, gender issues, human rights, and so on. The rapid development of the times makes Islamic sciences inevitably have to follow the flow of the times, and without exception the science of interpretation. The science of interpretation is required to always develop in the face of the complexity of humanitarian problems. It was here that the idea of the use of hermeneutics became a necessity for today's interpreters. Hermeneutics as a methodology in the interpretation of the Quran is considered quite important and urgent to do because hermeneutics does not only speak at the level of the text alone but also considers the context and role of subjectivity of an interpreter, so that by using the method of hermeneutics, interpretation or study of the Quran is expected to be able to become an actual contextual and answer the challenges of the times. The problem in this study is how Muhammad Syahrul's hermeneutic method in interpreting Quranic verses about Polygamy. The purpose of the study was to know and analyse Muhammad Shahrur's hermeneutics in interpreting Qur'anic verses about polygamy. The research method used in writing this paper is a qualitative research method through library research or literature review method using descriptive analysis writing method. The results showed that using his Limit Theory (Nadzariyah al-Hudud), Syahrur tried to reconstruct the understanding of polygamy by using quantity and quality standards together. In terms of quantity, the minimum standard limit for a person to marry is once (one wife), and the maximum limit is four wives. Islam allows a person to marry 4 (four) people together (polygamy), but in quality it is necessary to distinguish between the status of the first wife and the status of the second, third and fourth wives. For first wives (first marriages) one can marry a woman who is a virgin or widow whether or not she has children, but in a second, third, and/or fourth marriage (polygamy), the wife must be widowed and have orphans. So one cannot marry all one's wives in virgin condition, but on the contrary it is quite possible one marries wives who are all widows. This is in accordance with the main purpose of polygamy, which is to provide protection and protection and ensure the welfare and happiness of orphans living in intact families so as not to become homeless and avoid juvenile delinquency.