eleni drakaki

Dr. eleni drakaki

orcid

Research Focus & Metrics

Academic Career Length

28Years (1999-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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15 July 2020 in International Journal of Radiation Biology
Verified
Journal Article
Closed access
GKGeorgios Kareliotis
Georgios Kareliotis
ITIoanna Tremi
Ioanna Tremi
MKMyrsini Kaitatzi
Myrsini Kaitatzi
EDeleni drakaki
eleni drakaki
ASAlexandros A. Serafetinides
Alexandros A. Serafetinides
ALEXANDROS GEORGAKILASALEXANDROS GEORGAKILAS
ALEXANDROS GEORGAKILAS
Purpose: Numerous studies focus on cancer therapy worldwide, and although many advances have been recorded, the complexity of the disease dictates thinking out of the box to confront it. This study reviews some of the currently available ionizing (IR) and non-ionizing radiation (NIR)-based treatment methods and explores their possible combinations that lead to synergistic, multimodal approaches with promising therapeutic outcomes. Conclusion: Traditional techniques, like radiotherapy (RT) show decent results, although they cannot spare 100% the healthy tissues neighboring with the cancer ones. Targeted therapies, such as proton and photodynamic therapy (PT and PDT, respectively) present adequate outcomes, even though each one has its own drawbacks. In order to overcome these limitations, the combination of therapeutic modalities has been proposed and has already been showing promising results. At the same time, the recent advances in nanotechnology in the form of nanoparticles enhance cancer therapy, making multimodal treatments worthy of exploring and studying. The combination of RT and PDT has reached the level of clinical trials and is showing promising results. Moreover, in vitro and in vivo studies of nanoparticles with PDT have also provided beneficial results concerning enhanced radiation treatments. In any case, novel and multimodal approaches have to be adopted in order to achieve personalized, enhanced and effective cancer treatment.

17 December 2012 in Journal of Biomedical Optics
Verified
Journal Article
Closed access
PDF file
EDeleni drakaki
eleni drakaki
TVTheognosia Vergou
Theognosia Vergou
CDClio Dessinioti
Clio Dessinioti
ASAlexander J. Stratigos
Alexander J. Stratigos
CSCarmen Salavastru
Carmen Salavastru
CAChristina Antoniou
Christina Antoniou
The importance of dermatological noninvasive imaging techniques has increased over the last decades, aiming at diagnosing nonmelanoma skin cancer (NMSC). Technological progress has led to the development of various analytical tools, enabling the in vivo/in vitro examination of lesional human skin with the aim to increase diagnostic accuracy and decrease morbidity and mortality. The structure of the skin layers, their chemical composition, and the distribution of their compounds permits the noninvasive photodiagnosis of skin diseases, such as skin cancers, especially for early stages of malignant tumors. An important role in the dermatological diagnosis and disease monitoring has been shown for promising spectroscopic and imaging techniques, such as fluorescence, diffuse reflectance, Raman and near-infrared spectroscopy, optical coherence tomography, and confocal laser-scanning microscopy. We review the use of these spectroscopic techniques as noninvasive tools for the photodiagnosis of NMSC.

1 April 2009 in Skin Pharmacology and Physiology
Verified
Journal Article
Closed access
EDeleni drakaki
eleni drakaki
Evaggelos KaselourisEvaggelos Kaselouris
Evaggelos Kaselouris
MMM. Makropoulou
M. Makropoulou
ASA.A. Serafetinides
A.A. Serafetinides
ATA. Tsenga
A. Tsenga
CAC. Antoniou
C. Antoniou
The object of this study was to investigate whether laser-induced skin autofluorescence (LIF) and/or light reflectance spectra could provide a useful contrast between basal cell carcinoma (BCC) tissues and the surrounding healthy skin. Unstained human skin samples, excised from humans undergoing biopsy examination, were irradiated with a nitrogen laser (λ = 337 nm) for excitation of autofluorescence and a tungsten halogen lamp for the reflectance measurements. The ex vivo spectroscopic results were correlated with the histopathology images to distinguish the areas of BCC from those of the surrounding health skin. A simple spectral analysis technique was also applied for better skin diagnosis. In conclusion, it seems that LIF and reflectance spectra could be used to differentiate neoplastic from normal skin tissue using an appropriate classification model analysis.

1 September 2004 in Applied Physics A
Verified
Journal Article
Closed access
PDF file
EDeleni drakaki
eleni drakaki
Andreas - Germanos KarydasAndreas - Germanos Karydas
Andreas - Germanos Karydas
BKB. Klinkenberg
B. Klinkenberg
MKM. Kokkoris
M. Kokkoris
ASA.A. Serafetinides
A.A. Serafetinides
CZC. Zarkadas
C. Zarkadas

19 March 2007 in Skin Research and Technology
Verified
Journal Article
Closed access
PDF file
EDeleni drakaki
eleni drakaki
Ekaterina BorisovaEkaterina Borisova
Ekaterina Borisova
MMM. Makropoulou
M. Makropoulou
LAL. Avramov
L. Avramov
ASA. A. Serafetinides
A. A. Serafetinides
IAIvan Angelov
Ivan Angelov

11 March 2010 in European Journal of Physics
Verified
Journal Article
Open access
ISI Sianoudis
I Sianoudis
EDeleni drakaki
eleni drakaki
AHANNO HEIN
ANNO HEIN