Bahaa Elgendy

Prof. Bahaa Elgendy

Washington University School of Medicine St. Louis, MO, USA
orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 2015 in Cancer Cell
Verified
Journal Article
Closed access
CFColin A. Flaveny
Colin A. Flaveny
KGKristine Griffett
Kristine Griffett
Bahaa ElgendyBahaa Elgendy
Bahaa Elgendy
MKMelissa Kazantzis
Melissa Kazantzis
MSMonideepa Sengupta
Monideepa Sengupta
TBThomas P. Burris
Thomas P. Burris

20 May 2010 in Journal of Computer-Aided Molecular Design
Verified
Journal Article
Closed access
PDF file
AKAlan R. Katritzky
Alan R. Katritzky
CHC. Dennis Hall
C. Dennis Hall
Bahaa ElgendyBahaa Elgendy
Bahaa Elgendy
BDBogdan Draghici
Bogdan Draghici

23 December 2014 in Nature Communications
Verified
Journal Article
Open access
PDF file
SBSubhashis Banerjee
Subhashis Banerjee
YWYongjun Wang
Yongjun Wang
LSLaura A. Solt
Laura A. Solt
KGKristine Griffett
Kristine Griffett
MKMelissa Kazantzis
Melissa Kazantzis
TBThomas P. Burris
Thomas P. Burris
Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERBα and β, regulate sleep architecture and emotional behaviour in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behaviour. These data are consistent with increased anxiety-like behaviour of REV-ERBβ-null mice, in which REV-ERB agonists have no effect. These results indicate that pharmacological targeting of REV-ERB may lead to the development of novel therapeutics to treat sleep disorders and anxiety.

27 December 2012 in ACS Chemical Biology
Verified
Journal Article
Closed access
KGKristine Griffett
Kristine Griffett
LSLaura A. Solt
Laura A. Solt
Bahaa ElgendyBahaa Elgendy
Bahaa Elgendy
TKTheodore M. Kamenecka
Theodore M. Kamenecka
TBThomas P. Burris
Thomas P. Burris

1 August 2020 in European Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
PEPerihan Elzahhar
Perihan Elzahhar
SWShrouk M. Abd El Wahab
Shrouk M. Abd El Wahab
MEMohamed Elagawany
Mohamed Elagawany
HDHoda Daabees
Hoda Daabees
ABAhmed S.F. Belal
Ahmed S.F. Belal
Claudiu SupuranClaudiu Supuran
Claudiu Supuran

1 December 2015 in Journal of Electroanalytical Chemistry
Verified
Journal Article
Closed access
HEHany M. Abd El-Lateef
Hany M. Abd El-Lateef
Ahmed Abu-Dief MohammedAhmed Abu-Dief Mohammed
Ahmed Abu-Dief Mohammed
Bahaa ElgendyBahaa Elgendy
Bahaa Elgendy