Objective: To synthesize and analyze the prevalence, composition, longitudinal stability, and predictors of cancer symptom clusters in children and adolescents undergoing chemotherapy. Method: A systematic literature review was conducted in accordance with the PRISMA 2020 guidelines. Evidence was sourced from MEDLINE/PubMed, Cochrane Library, Embase, PsycINFO, and Web of Science, as well as clinical trial registries (Clinical Trials WHO-ICTRP) and gray literature. The search was performed in February 2025, with no restrictions on publication date or language. Two independent reviewers screened and selected the studies. The methodological quality of the included studies was assessed using design-specific tools, and the findings were synthesized narratively. Results: A total of 6221 records were identified, with 12 studies meeting the inclusion criteria. These studies were published between 2010 and 2024 in the United States, Brazil, China, and Turkey. Cancer symptom clusters in children and adolescents followed well-defined patterns, with the gastrointestinal, emotional, fatigue-related, somatic, and self-image clusters being the most prevalent. Conclusions: Early identification of these cancer symptom clusters is essential for guiding interprofessional teams in delivering personalized, evidence-based care to children and adolescents with cancer and their families.

This is a systematic review protocol whose objective is to synthesize and evaluate the prevalence, composition, stability, predictors and outcomes of cancer symptom clusters in children and adolescents undergoing chemotherapy. This systematic review protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols-PRISMA-P. The search for evidence will include MEDLINE/PubMed, Cochrane Library; Embase; PsycINFO and Web-of-Science; plus clinical trial registry websites (ClinicalTrials.gov and WHO-ICTRP) and additional sources: The British Library, Google Scholar, and preprints for Health Sciences-medRXiv. Two researchers will independently extract and evaluate the included studies. The methodological quality of the studies will be assessed using specific tools per study design. The results will be presented through tables, graphs, qualitative synthesis and will be evaluated based on the outcomes. This will be the first systematic review with high methodological rigor to gather evidence on oncological symptom clusters in the area of Pediatric Oncology. Understanding the experiences of children and adolescents with cancer on oncological symptom clusters can provide a scientific basis for directing personalized therapies, especially for the management of concomitant symptoms.

Introdução: A violência é um importante agravo de saúde pública que se destaca em determinados grupos vulneráveis, sendo necessário melhor identificação de suas características para efetividade das ações preventivas. Objetivos: Caracterizar os casos notificados de violência contra grupos vul­neráveis no Espírito Santo, no período de 2011 a 2018. Métodos: Foi realizado um estudo descritivo, utilizando todos os casos de violência registrados no Sistema Nacional de Agravos de Notificação. As variáveis analisadas incluíram características da vítima, do agressor e do evento. O projeto foi aprovado pelo comitê de ética, e as análises foram realizadas no Stata 14.1. Resultados: A frequência de notificação de violência contra grupos vulneráveis foi de 88,5% (IC95%: 88,1-88,8). A violência contra crianças, adolescentes, mulheres e idosos foi majoritariamente cometida por homens. As víti­mas foram principalmente da raça cor parda/preta, sem deficiência ou transtorno, residentes da zona urbana/periurbana e do sexo feminino. A violência é mais comumente praticada nas residências e tem caráter de repetição. Conclusão: A violência está presente em todo o ciclo de vida, sendo essencial promover ações de enfrentamento a esse agravo.