Flavonoids are natural polyphenolic compounds that mainly possess antioxidant properties due to more hydroxyl groups in their structure and play an important role in combatting many diseases. Myricetin is a flavonoid found in grapes, green tea, fruits, and vegetables and is not only an antioxidant but also is a pro-oxidant. Myricetin is sparingly soluble in water and restricts its properties due to low bioavailability. The present study reports the liposomal nanoformulations of myricetin to improve its bioavailability with reduced pro-oxidant activity. The nanoformulated myricetin was characterized using different photophysical tools, such as dynamic light scattering (DLS), zeta potential, and scanning electron microscopy (SEM). The effect of nanoencapsulated myricetin on the developing zebrafish embryo was studied in terms of microscopic observations, cumulative hatchability, and antioxidant activities, such as catalase, glutathione peroxidase, and superoxide dismutase, after treating the zebrafish embryo with standard oxidant hydrogen peroxide. The results obtained from the cumulative hatchability, developmental studies, and antioxidant assays indicated that the liposomal nanoformulation of myricetin had enhanced antioxidant activity, leading to defense against oxidative stress. The formulation was highly biocompatible, as evidenced by the cumulative hatching studies as well as microscopic observations. The positive effects of liposomal nanoformulation on zebrafish embryos can open an avenue for other researchers to carry out further related research and to check its activities in clinical studies and developmental studies.

Background: Economic development and vast changes in food habits have accelerated the consumption of junk foods, which are the leading causes of several disorders that turn the majority of the people to use various herbal formulations or drugs for preventing various lifestyle diseases. Nutraceuticals are the borderline apparatus between nutrients and drugs that provide supplementation of the particular nutrient with a favorable health effect. Objective: Various nutraceutical compounds like vitamins, spices, polyphenols, prebiotics, and probiotics in the form of powders, tablets, and capsules are currently marketed globally. Among them, previous literature have reported that polyphenols are the most promising compounds that have been proven to treat various chronic diseases like cancer, hypertension, diabetes mellitus (DM), osteoporosis, osteoarthritis, dyslipidemia, multiple sclerosis, congenital anomalies, Alzheimer’s disease, etc. It is warranted to discuss the benefits of nanoformulations of nutraceuticals. Methods: We have searched PubMed using the keywords nutraceuticals, nanoformulations, therapeutic approaches, bionanotechnology, and therapeutics. The relevant papers and classical papers in this field were selected to write this review. Results and Discussion: The different classifications of nutraceuticals were described in this review. The comparison between the different categories of nutraceuticals with their nanoformulated forms was made, explaining the benefits of nanoformulations regarding stability, bioavailability, enhanced anti-oxidant properties, etc. A glimpse of the drawbacks of nanoformulations was also included. Conclusion: The current review highlights an overview of various nanoformulated nutraceuticals and their approach towards the treatment of multiple diseases.

We are exposed to different types of radiation from natural sources or for biomedical diagnostic and therapeutic purposes at different doses or times. The dose, duration, and number of exposures can cause multiple effects both in vivo and in vitro. Several researchers have explored the effects of ionizing and non-ionizing radiation in cell lines and animal models. Macromolecules, such as DNA, RNA, and proteins, are the primary targets of damage and can lead to several diseases, including cancer and even cell death. Chronic low-dose exposure of cells to radiation can cause alterations in gene expression and can be deleterious to the fate of the cells. We aim to discuss the implications of multiple radiations on different biological systems, including how nanotechnology can facilitate the effects of radiation in therapeutics. In this review, we discuss the in vitro and in vivo changes that occur due to exposure to different types of radiation used in diagnosis, therapeutics, and other means, such as radiation equipment operators and patients being exposed. The effects of ionizing and non-ionizing radiation have been discussed separately. We have also mentioned in detail about the human-caused accidents of Hiroshima and Chernobyl in this article. The application of nanotechnology in facilitating the effects of radiation in the therapy and management of radioresistance of cells has also been discussed. The radio resistance and method to improve the radiosensitivity have also been mentioned. This review article can reflect the recent developments in the various uses of ionizing and non-ionizing radiation in biomedical field and will open up new avenues to utilize radiation in a more prudent way. The role of nanotechnology in reducing the harmful effects of radiation is also discussed.