Grigory Machakhtyrov was born in the Verkhnevilyui region of the Republic of Sakha (Yakutia), Russia. In 1999 he graduated from the Yakutsk State Agricultural Academy with a degree in veterinary medicine. He lectured (2008–2019), worked as dean of the Faculty of Veterinary Medicine. He studies the physiology of animals, the use of reproductive technologies in animal husbandry in the North and the Arctic, including the effect of warming on animals. In 2006 he defended his thesis for the degree of candidate of biological sciences (physiology).