"Guaraná" (Paullinia cupana) is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precision, accuracy, selectivity and robustness. Findings showed that 100% of the herbal medicinal products analyzed did not provide satisfactory results concerning the presence of four markers, 60% had three markers (caffeine, catechin and epicatechin), while 40% had only caffeine at tested dosage forms. In addition, after 30 minutes, only capsule A showed at least 80% of the dissolved markers. In other capsules, marker dissolution did not exceed 60% whereas 60% of the samples had some characteristic pharmacotechnical problems. These results evidence the need for rigorous quality control to help ensure the therapeutic action of these drugs. To this end, dissolution studies are an essential tool for quality assurance of herbal medicines.

This study explores a nanoemulsion formulated with açaí seed oil, known for its rich fatty acid composition and diverse biological activities. This study aimed to characterise a nanoemulsion formulated with açaí seed oil and explore its cytotoxic effects on HeLa and SiHa cervical cancer cell lines, alongside assessing its antioxidant and toxicity properties both in vitro and in vivo. Extracted from fruits sourced in Brazil, the oil underwent thorough chemical characterization using gas chromatography–mass spectrometry. The resulting nanoemulsion was prepared and evaluated for stability, particle size, and antioxidant properties. The nanoemulsion exhibited translucency, fluidity, and stability post centrifugation and temperature tests, with a droplet size of 238.37, PDI -9.59, pH 7, and turbidity 0.267. In vitro assessments on cervical cancer cell lines revealed antitumour effects, including inhibition of cell proliferation, migration, and colony formation. Toxicity tests conducted in cell cultures and female Swiss mice demonstrated no adverse effects of both açaí seed oil and nanoemulsion. Overall, açaí seed oil, particularly when formulated into a nanoemulsion, presents potential for cancer treatment due to its bioactive properties and safety profile.

Drug-excipient interaction studies are fundamental for the efficient development of new formulations. These interactions directly influence drug stability, loading capacity, controlled release, and bioavailability, which are essential aspects to optimize therapeutic efficacy and minimize possible adverse effects. This research aimed to investigate the physicochemical compatibility of OLZ with lipid excipients intended for NLC formulation. Binary mixtures (1:1, w/w) of OLZ with a range of solid, liquid lipids and surfactants were examined using thermogravimetry (TG/DTG) and differential thermal analysis (DTA), and Fourier-transform infrared spectroscopy (FTIR). Isothermal stress tests were conducted at 60 ± 2 °C for a period of up to 30 days, and the OLZ content was measured using a validated HPLC method. The thermal and spectral analyses indicated interactions between OLZ and excipients such as oleic acid, Capmul®, Captex®, and Span® 60, as demonstrated by shifts or suppression of characteristic OLZ peaks. The degradation observed under stress conditions confirmed limited stability with stearic acid, lauric acid, palmitic acid, glyceryl monostearate, oleic acid, Capmul® and Span®60 and 80 , with OLZ content reduced to 55.6–70.6% after 30 days in the most affected mixtures, compared to 100.0 ± 2.9% for pure OLZ. Overall, these findings emphasize the significance of excipient selection to guarantee stability and compatibility in the formulation of OLZ-loaded NLC systems.

Objetivou-se levantar, na literatura nacional e internacional, as evidências científicas acerca dos indicadores de riscos ocupacionais e os reflexos destes para a saúde da equipe de enfermagem em unidade neonatal. Estudo de revisão integrativa, realizado durante o mês de outubro de 2020. A busca foi realizada por meio do portal da Biblioteca Virtual em Saúde, nas bases de dados LILACS, MEDLINE, IBECS e BDENF, de forma simultânea, por artigos em inglês, português e espanhol com resumo e texto disponíveis na íntegra, publicados entre 2015 e 2020. Excluíram-se os artigos em duplicata, os de revisão, os classificados metodologicamente como tese, dissertação ou monografia bem como aqueles que não se enquadravam no tema. Identificou-se 15 publicações, das quais, 5 atenderam os critérios de elegibilidade. Quanto ao risco ocupacional identificou-se: dano psicológico: estresse ocupacional; burnout; desejo de abandonar o trabalho, exaustão emocional, desmotivação profissional; dano físico: sobrecarga de trabalho; condições ambientais inadequadas e ruído; dano social: dificuldades de relacionamento interpessoal e necessidade de restringir os contatos pessoais. Os reflexos na saúde do trabalhador foram: depressão, frustração, raiva, amargura, negatividade e compulsividade; fadiga, exaustão, falta de atenção, baixa imunidade; irritabilidade, cinismo, baixa empatia. Os riscos laborais refletem negativamente na saúde dos trabalhadores de enfermagem. Recomenda-se estratégias de prevenção e controle destes, buscando promover um ambiente laboral em conformidade com os princípios da segurança vigente na legislação.

The solidification of self-microemulsifying drug delivery systems (SMEDDS) represents a significant advance in the transition from self-microemulsifying te