Hortensia Rodriguez

Prof. Hortensia Rodriguez

Yachay Tech University
orcid

Research Focus & Metrics

Academic Career Length

28Years (1999-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
21 December 2015 in ACS Combinatorial Science
Verified
Journal Article
Closed access
VCVida Castro
Vida Castro
Hortensia RodriguezHortensia Rodriguez
Hortensia Rodriguez
Fernando AlbericioFernando Albericio
Fernando Albericio

31 October 2019 in Journal of Materials Science
Verified
Journal Article
Open access
PDF file
EJEdison Jimenez
Edison Jimenez
Hortensia RodriguezHortensia Rodriguez
Hortensia Rodriguez
The aggregation-induced emission (AIE) is a photochemical process described in 2001, where the aggregation of specific kinds of organic compounds enhances the emission of light performed by these organic compounds. Since then, this phenomenon had attracted much interest because of its potential application in optics, electronics, energy and bioscience. In this review, the main concepts of AIE are going to be explained through the mechanistic decipherment of these photophysical processes. Additionally, some AIE systems will be discussed, describing the phosphorescence enhancement induced in organic molecules by this effect, but we will be focusing on the cyano-containing AIEgens, its recent advances and the driving forces that lead to the AIE effect in these cyano-containing molecules.

1 April 2003 in Tetrahedron Letters
Verified
Journal Article
Closed access
Hortensia RodriguezHortensia Rodriguez
Hortensia Rodriguez
MSMargarita Suarez
Margarita Suarez
RPRolando Perez Pineiro
Rolando Perez Pineiro
APAlain Petit
Alain Petit
ALAndré Loupy
André Loupy

26 May 2022 in Frontiers in Chemistry
Verified
Journal Article
Open access
AEAlexis Eras
Alexis Eras
DCDanna Castillo
Danna Castillo
MSMargarita Suárez
Margarita Suárez
Nelson Santiago VispoNelson Santiago Vispo
Nelson Santiago Vispo
Fernando AlbericioFernando Albericio
Fernando Albericio
Hortensia RodriguezHortensia Rodriguez
Hortensia Rodriguez
Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer are usually so intense and invasive that they weaken the patient to cure as dangerous as the own disease. From some time ago until today, to reduce resistance generated by the constant administration of the drug and improve its pharmacokinetics, scientists have been developing drug delivery system (DDS) technology. DDS platforms aim to maximize the drugs’ effectiveness by directing them to reach the affected area by the disease and, therefore, reduce the potential side effects. Erythrocytes, antibodies, and nanoparticles have been used as carriers. Eleven antibody–drug conjugates (ADCs) involving covalent linkage has been commercialized as a promising cancer treatment in the last years. This review describes the general features and applications of DDS focused on the covalent conjugation system that binds the antibody carrier to the cytotoxic drug.

19 February 2009 in Journal of Medicinal Chemistry
Verified
Journal Article
Open access
RPRolando Perez Pineiro
Rolando Perez Pineiro
ABAsdrubal Burgos
Asdrubal Burgos
DJDeuan C. Jones
Deuan C. Jones
LALena C. Andrew
Lena C. Andrew
Hortensia RodriguezHortensia Rodriguez
Hortensia Rodriguez
David Scott WishartDavid Scott Wishart
David Scott Wishart
The implementation of a novel sequential computational approach that can be used effectively for virtual screening and identification of prospective ligands that bind to trypanothione reductase (TryR) is reported. The multistep strategy combines a ligand-based virtual screening for building an enriched library of small molecules with a docking protocol (AutoDock, X-Score) for screening against the TryR target. Compounds were ranked by an exhaustive conformational consensus scoring approach that employs a rank-by-rank strategy by combining both scoring functions. Analysis of the predicted ligand−protein interactions highlights the role of bulky quaternary amine moieties for binding affinity. The scaffold hopping (SHOP) process derived from this computational approach allowed the identification of several chemotypes, not previously reported as antiprotozoal agents, which includes dibenzothiepine, dibenzooxathiepine, dibenzodithiepine, and polycyclic cationic structures like thiaazatetracyclo-nonadeca-hexaen-3-ium. Assays measuring the inhibiting effect of these compounds on T. cruzi and T. brucei TryR confirm their potential for further rational optimization.

1 May 2005 in Bioorganic & Medicinal Chemistry
Verified
Journal Article
Closed access
JCJulieta Coro
Julieta Coro
RPRolando Perez Pineiro
Rolando Perez Pineiro
Hortensia RodriguezHortensia Rodriguez
Hortensia Rodriguez
MSMargarita Suárez
Margarita Suárez
CVCeleste Vega
Celeste Vega
AGAlicia Gómez-Barrio
Alicia Gómez-Barrio