José G. Sampedro is a Professor at the Institute of Physics, University of San Luis Potosí (UASLP), México. He received his undergraduate from the Metropolitan Autonomous University (UAM-X), and a Ph.D. from the National University of México (Faculty of Chemistry, UNAM).
During Dr. Sampedro’s training at the Institute of Cellular Physiology, UNAM (1998 - 2002), he was focused on researching the mechanisms of structural and functional protection of membrane proteins during stress (dehydration and heat-shock). The viscosity mediated by solute (carbohydrate) accumulation and its structural and functional effects (as described by Kramers´ theory) on motion dependent processes in enzymes was one of his main areas of research.
Dr. Sampedro joined (2010) as faculty member at the Institute of Physics (UASLP) in San Luis Potosí, México. His research program is aimed to study: a) the application of Kramers´ theory on rate reactions (structural and chemical) in enzymes (membrane and cytosolic) or the effect of high viscosity on enzyme catalysis and structural dynamics (thermal unfolding, folding, etc.), b) the structure and function of P-type ATPases (H+- and Ca2+-ATPase), c) ligand binding in enzymes (membrane and cytoplasmic), d) the study of enzyme active sites using molecular docking and molecular dynamics simulation, e) the mechanisms of protein stabilization (structure and function) in cells, and the role of the accumulation of compatible solutes (trehalose) during stress.
José G. Sampedro is a Professor at the Institute of Physics, University of San Luis Potosí (UASLP), México. He received his undergraduate from the Metropolitan Autonomous University (UAM-X), and a Ph.D. from the National University of México (Faculty of Chemistry, UNAM).
During Dr. Sampedro’s training at the Institute of Cellular Physiology, UNAM (1998 - 2002), he was focused on researching the mechanisms of structural and functional protection of membrane proteins during stress (dehydration and heat-shock). The viscosity mediated by solute (carbohydrate) accumulation and its structural and functional effects (as described by Kramers´ theory) on motion dependent processes in enzymes was one of his main areas of research.
Dr. Sampedro joined (2010) as faculty member at the Institute of Physics (UASLP) in San Luis Potosí, México. His research program is aimed to study: a) the application of Kramers´ theory on rate reactions (structural and chemical) in enzymes (membrane and cytosolic) or the effect of high viscosity on enzyme catalysis and structural dynamics (thermal unfolding, folding, etc.), b) the structure and function of P-type ATPases (H+- and Ca2+-ATPase), c) ligand binding in enzymes (membrane and cytoplasmic), d) the study of enzyme active sites using molecular docking and molecular dynamics simulation, e) the mechanisms of protein stabilization (structure and function) in cells, and the role of the accumulation of compatible solutes (trehalose) during stress.