Main research program is broadly dedicated to the field of stromal biology, with a fundamental focus on the plasticity of fibroblasts and their pathogenic roles across a wide spectrum of human diseases. Recognizing fibroblasts as the central architects of tissue homeostasis, and exploring how the dysregulation and persistent activation of these cells serve as a shared pathological driver in various conditions, ranging from chronic fibrotic disorders to cancer. Building upon this comprehensive understanding of fibroblast biology, the core research uniquely centers on the Tumor Microenvironment. I am committed to decoding the dynamic, bidirectional communication networks between malignant cells and Cancer-Associated Fibroblasts. My investigations elucidate how tumor cells utilize paracrine signaling and extracellular vesicles to reprogram the stromal compartment, thereby forging a desmoplastic and immunosuppressive niche that promotes tumor metastasis and therapeutic resistance.