This study shows the results of a simulation tool using the TRNSyS 2017 simulator, validated with experimental data from a greenhouse in an arid zone in northwestern Mexico. Additionally, experimental data on the performance of geothermal heat pumps are shown during the year 2020 in heating and cooling mode. With this information, an average deviation of the simulator for the outlet fluid temperature of the geothermal heat exchanger (GHE) of 2.77% and an average deviation of the coefficient of performance in cooling mode (EER) of the geothermal heat pump (GHP) of 3.7% was obtained. In the experimental study, it was observed that in the last 2 weeks of July and the first 2 weeks of August, the subsoil is saturated, which causes a decrease in the thermal inertia of the GHE. During the experimental study, it was possible to determine that the flow indicated in the GHE to obtain the highest performance of the GHP system in greenhouses in arid zones corresponds to 1 GPM, obtaining an EER of 3.24.