The spatial distribution of tourism has a profound impact on its operational efficiency and geographical relevance. Point of interest (POI), as a kind of spatial data shared by subject and object, can reflect the spatial distribution form and function of tourism geographical objects under the all-for-one tourism policy. Continuous satellite observation and in-depth study of night lights pave the way to clarify human activities and socio-economic dynamics. The purpose of this paper is to investigate the seasonal changes of night light images and their correlation with tourism in 122 counties (cities, districts) of Hunan Province. We obtained night earth observation data (seasonality) and POI in 2019 and processed them by Geographic Information System and statistical analysis (ordinary least squares (OLS) and geographically weighted regression (GWR)). The results show that the luminous radiation intensity is highly correlated with the POI of tourism activities. The POI of different tourism activities in different regions shows obvious spatial heterogeneity and seasonal differences, which is the result of the comprehensive effect of tourism resource distribution and social environment in Hunan Province. GWR has proved to be a more effective tool. It provides a new method and perspective for tourism research and especially reveals the geographical spatial differences of tourism activities, which is helpful to study the spatial distribution and seasonality of tourism at the county level. In addition, the spatial evaluation of the contribution of tourism and luminous radiation can provide reference and suggestions for relevant departments to formulate tourism night protection measures.