Global food production faces many challenges, including climate change, a water crisis, land degradation, and desertification. These challenges require research into non-traditional sources of human foods. Edible mushrooms are considered an important next-generation healthy food source. Edible mushrooms are rich in proteins, dietary fiber, vitamins, minerals, and other bioactive components (alkaloids, lactones, polysaccharides, polyphenolic compounds, sesquiterpenes, sterols, and terpenoids). Several bioactive ingredients can be extracted from edible mushrooms and incorporated into health-promoting supplements. It has been suggested that several human diseases can be treated with extracts from edible mushrooms, as these extracts have biological effects including anticancer, antidiabetic, antiviral, antioxidant, hepatoprotective, immune-potentiating, and hypo-cholesterolemic influences. The current study focuses on sustainable approaches for handling edible mushrooms and their secondary metabolites, including biofortification. Comparisons between edible and poisonous mushrooms, as well as the common species of edible mushrooms and their different bioactive ingredients, are crucial. Nutritional values and the health benefits of edible mushrooms, as well as different biomedical applications, have been also emphasized. Further research is needed to explore the economic sustainability of different medicinal mushroom bioactive compound extracts and their potential applications against emerging diseases such as COVID-19. New approaches such as nano-biofortification are also needed to supply edible mushrooms with essential nutrients and/or to increase their bioactive ingredients.

The field of biotechnology presents us with a great chance to use many organisms, such as mushrooms, to find suitable solutions for issues that include the accumulation of agro-wastes in the environment. The green biotechnology of mushrooms (Pleurotus ostreatus L.) includes the myco-remediation of polluted soil and water as well as bio-fermentation. The circular economy approach could be effectively achieved by using oyster mushrooms (Pleurotus ostreatus L.), of which the substrate of their cultivation is considered as a vital source for producing biofertilizers, animal feeds, bioenergy, and bio-remediators. Spent mushroom substrate is also considered a crucial source for many applications, including the production of enzymes (e.g., manganese peroxidase, laccase, and lignin peroxidase) and bioethanol. The sustainable management of agro-industrial wastes (e.g., plant-based foods, animal-based foods, and non-food industries) could reduce, reuse and recycle using oyster mushrooms. This review aims to focus on the biotechnological applications of the oyster mushroom (P. ostreatus L.) concerning the field of the myco-remediation of pollutants and the bio-fermentation of agro-industrial wastes as a sustainable approach to environmental protection. This study can open new windows onto the green synthesis of metal-nanoparticles, such as nano-silver, nano-TiO₂ and nano-ZnO. More investigations are needed concerning the new biotechnological approaches.

Soil is the main component in the agroecosystem besides water, microbial communities, and cultivated plants. Several problems face soil, including soil pollution, erosion, salinization, and degradation on a global level. Many approaches have been applied to overcome these issues, such as phyto-, bio-, and nanoremediation through different soil management tools. Mushrooms can play a vital role in the soil through bio-nanoremediation, especially under the biological synthesis of nanoparticles, which could be used in the bioremediation process. This review focuses on the green synthesis of nanoparticles using mushrooms and the potential of bio-nanoremediation for polluted soils. The distinguished roles of mushrooms of soil improvement are considered a crucial dimension for sustainable soil management, which may include controlling soil erosion, improving soil aggregates, increasing soil organic matter content, enhancing the bioavailability of soil nutrients, and resorting to damaged and/or polluted soils. The field of bio-nanoremediation using mushrooms still requires further investigation, particularly regarding the sustainable management of soils.

Is there any relationship between plant nutrition and human health? The overall response to this question is very positive, and a strong relationship between the nutrition of plants and humans has been reported in the literature. The nutritional status of edible plants consumed by humans can have a negative or positive impact on human health. This review was designed to assess the importance of plant bioactive compounds for human health under the umbrella of sustainable agriculture. With respect to the first research question, it was found that plant bioactives (e.g., alkaloids, carotenoids, flavonoids, phenolics, and terpenoids) have a crucial role in human health due to their therapeutic benefits, and their potentiality depends on several factors, including botanical, environmental, and clinical attributes. Plant bioactives could be produced using plant tissue culture tools (as a kind of agro-biotechnological method), especially in cases of underexploited or endangered plants. Bioactive production of plants depends on many factors, especially climate change (heat stress, drought, UV radiation, ozone, and elevated CO₂), environmental pollution, and problematic soils (degraded, saline/alkaline, waterlogged, etc.). Under the previously mentioned stresses, in reviewing the literature, a positive or negative association was found depending on the kinds of stress or bioactives and their attributes. The observed correlation between plant bioactives and stress (or growth factors) might explain the importance of these bioactives for human health. Their accumulation in stressed plants can increase their tolerance to stress and their therapeutic roles. The results of this study are in keeping with previous observational studies, which confirmed that the human nutrition might start from edible plants and their bioactive contents, which are consumed by humans. This review is the first report that analyzes this previously observed relationship using pictorial presentation.

Natural fibers are an important source for producing polymers, which are highly applicable in their nanoform and could be used in very broad fields such as filtration for water/wastewater treatment, biomedicine, food packaging, harvesting, and storage of energy due to their high specific surface area. These natural nanofibers could be mainly produced through plants, animals, and minerals, as well as produced from agricultural wastes. For strengthening these natural fibers, they may reinforce with some substances such as nanomaterials. Natural or biofiber-reinforced bio-composites and nano–bio-composites are considered better than conventional composites. The sustainable application of nanofibers in agricultural sectors is a promising approach and may involve plant protection and its growth through encapsulating many bio-active molecules or agrochemicals (i.e., pesticides, phytohormones, and fertilizers) for smart delivery at the targeted sites. The food industry and processing also are very important applicable fields of nanofibers, particularly food packaging, which may include using nanofibers for active–intelligent food packaging, and food freshness indicators. The removal of pollutants from soil, water, and air is an urgent field for nanofibers due to their high efficiency. Many new approaches or applicable agro-fields for nanofibers are expected in the future, such as using nanofibers as the indicators for CO and NH₃. The role of nanofibers in the global fighting against COVID-19 may represent a crucial solution, particularly in producing face masks.

Under the global water crisis, utilizing low-quality water sources in agriculture for irrigation has offered an effective solution to address the shortage of water. Using an excess of low-quality water sources may cause serious risks to the environment, which threaten crop safety and human health. Three kinds of irrigation water (0.413, 1.44, and 2.84 dS m⁻¹) were selected under foliar-applied bio-nanofertilizers of selenium (100 mg L⁻¹) and copper (100 mg L⁻¹) in individual and/or combined application. The nanofertilizers were tested on the production of tomato under greenhouse. After harvesting, the quality of tomato yield and soil biology was evaluated. Using saline water for irrigation caused many main features in this study such as increasing the accumulation of salts, soil organic matter, and CaCO₃ in soil by 84.6, 32.3, and 18.4%, respectively, compared to control. The highest tomato yield (2.07 kg plant⁻¹) and soluble solids content (9.24%) were recorded after irrigation with low water quality (2.84 dS m⁻¹) and nano-Cu fertilization. The plant enzymatic antioxidants and soil biological activity were decreased in general due to the salinity stress of irrigation water. After 30 days from transplanting, all studied soil biological parameters (soil microbial counts and enzymes) were higher than the same parameters at harvesting (80 days) under different categories of water quality. The values of all soil biological parameters were decreased by increasing water salinity. This study was carried out to answer the question of whether the combined nanofertilizers of selenium and copper can promote tomato production under saline water irrigation. Further investigations are still needed concerning different applied doses of these nanofertilizers.