Dr. Khanyisani Ziqubu
University of the Western Cape, Cape Town, Western Cape, South Africa
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Academic Career Length
8Years (2019-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications15 March 2023 in World Journal of Diabetes
Journal Article
PDPhiwayinkosi V. Dludla
Phiwayinkosi V. DludlaSMSihle E Mabhida
Sihle E Mabhida
Khanyisani ZiqubuBNBongani B Nkambule
Bongani B Nkambule
SMSithandiwe E Mazibuko-Mbeje
Sithandiwe E Mazibuko-Mbeje
AKAndre Pascal Kengne
Andre Pascal Kengne
+3
Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
5 March 2022 in Pharmacological Research
Journal Article
NMNdivhuwo Muvhulawa
Ndivhuwo Muvhulawa
PDPhiwayinkosi V. Dludla
Phiwayinkosi V. DludlaKhanyisani Ziqubu
Sinenhlanhla MthembuFMFikile Mthiyane
Fikile Mthiyane
SMSithandiwe Mazibuko-Mbeje
Sithandiwe Mazibuko-Mbeje +1
Journal Article
SSSamkelisiwe Shabalala
Samkelisiwe Shabalala
Rabia JohnsonABAlbertus Basson
Albertus BassonKhanyisani ZiqubuNHNokulunga Hlengwa
Nokulunga HlengwaPDPhiwayinkosi V. Dludla
Phiwayinkosi V. Dludla +6
Lipid peroxidation, including its prominent byproducts such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE), has long been linked with worsened metabolic health in patients with type 2 diabetes (T2D). In fact, patients with T2D already display increased levels of lipids in circulation, including low-density lipoprotein-cholesterol and triglycerides, which are easily attacked by reactive oxygen molecules to give rise to lipid peroxidation. This process severely depletes intracellular antioxidants to cause excess generation of oxidative stress. This consequence mainly drives poor glycemic control and metabolic complications that are implicated in the development of cardiovascular disease. The current review explores the pathological relevance of elevated lipid peroxidation products in T2D, especially highlighting their potential role as biomarkers and therapeutic targets in disease severity. In addition, we briefly explain the implication of some prominent antioxidant enzymes/factors involved in the blockade of lipid peroxidation, including termination reactions that involve the effect of antioxidants, such as catalase, coenzyme Q10, glutathione peroxidase, and superoxide dismutase, as well as vitamins C and E.
16 February 2023 in Frontiers in Endocrinology
Journal Article
Khanyisani ZiqubuPDPhiwayinkosi V. Dludla
Phiwayinkosi V. Dludla
Sinenhlanhla MthembuBNBongani B. Nkambule
Bongani B. Nkambule
SMSihle E. Mabhida
Sihle E. Mabhida
SMSithandiwe Mazibuko-Mbeje
Sithandiwe Mazibuko-Mbeje +2
Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity. Although BAT is the opposite of white adipose tissue (WAT) which is responsible for energy storage, BAT shares thermogenic capacity with beige adipose tissue that emerges from WAT depots. This is unsurprising as both BAT and beige adipose tissue display a huge difference from WAT in terms of their secretory profile and physiological role. In obesity, the content of BAT and beige adipose tissue declines as these tissues acquire the WAT characteristics via the process called “whitening”. This process has been rarely explored for its implication in obesity, whether it contributes to or exacerbates obesity. Emerging research has demonstrated that BAT/beige adipose tissue whitening is a sophisticated metabolic complication of obesity that is linked to multiple factors. The current review provides clarification on the influence of various factors such as diet, age, genetics, thermoneutrality, and chemical exposure on BAT/beige adipose tissue whitening. Moreover, the defects and mechanisms that underpin the whitening are described. Notably, the BAT/beige adipose tissue whitening can be marked by the accumulation of large unilocular lipid droplets, mitochondrial degeneration, and collapsed thermogenic capacity, by the virtue of mitochondrial dysfunction, devascularization, autophagy, and inflammation.
1 August 2020 in Pharmacological Research
Journal Article
Khanyisani ZiqubuPDPhiwayinkosi V. Dludla
Phiwayinkosi V. Dludla
EJElizabeth Joubert
Elizabeth JoubertCMChristo J.F. Muller
Christo J.F. Muller
JLJohan Louw
Johan Louw
SMSithandiwe Mazibuko-Mbeje
Sithandiwe Mazibuko-Mbeje +3
17 November 2021 in Food & Function
Journal Article
KMKabelo Mokgalaboni
Kabelo MokgalaboniYNYonela Ntamo
Yonela NtamoKhanyisani ZiqubuTNTawanda M. Nyambuya
Tawanda M. Nyambuya
BNBongani B. Nkambule
Bongani B. Nkambule
PDPhiwayinkosi V. Dludla
Phiwayinkosi V. Dludla +4
The mechanism of action of curcumin targets diverse markers of both oxidative stress and inflammation to mitigate metabolic syndromes such as obesity, T2D, NAFLD, or even dyslipidemia. Arrow pointing up: Increase; Arrow pointing down: decrease.
About Me
Dr Khanyisani Ziqubu holds a PhD in Biochemistry from North-West University (NWU), South Africa. His research contributions include over 40 peer-reviewed publications in leading journals, with more than 1,500 citations and an h-index of 23. Dr Ziqubu’ research is centered on elucidating the molecular and pathophysiological mechanisms that drive obesity and its associated metabolic diseases, with the goal of translating these insights into innovative therapeutic strategies that bridge basic and clinical science. Dr Ziqubu is a member of the South African Society of Biochemistry and Molecular Biology (SASBMB) and has received several awards, including the IUBMB-FAOBMB-ComBio Young Scientist Fellowship, a testament to his promising research contributions and potential for global impact. He has held research and teaching positions at the South African Medical Research Council, the University of Zululand, and NWU, where he also lectures in advanced cellular and molecular biology. He has demonstrated consistent international engagement, presenting at prestigious events such as the International Congress of Endocrinology (Dubai), Biomolecular Horizons (Australia), and workshops in Europe and South Africa. His profile reflects strong mentorship skills with supervision of postgraduate students, successful acquisition of fellowships, and active involvement in community outreach programs related to science and diabetes awareness, aligning research with societal needs.
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