Khawla Bouaouda

Dr. Khawla Bouaouda

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
7 November 2023 in Frontiers in Nutrition
Verified
Journal Article
Open access
MOMourad Oukheda
Mourad Oukheda
KBKhawla Bouaouda
Khawla Bouaouda
KMKarima Mohtadi
Karima Mohtadi
HLHalima Lebrazi
Halima Lebrazi
ADAbdelfettah Derouiche
Abdelfettah Derouiche
HTHassan Taki
Hassan Taki
Aim: This study aims to analyze and compare dietary intake, as well as to examine the associations between energy intake in terms of macronutrients, body composition, and physical fitness (PF) specifically cardiorespiratory endurance (CE) among a sample of young adolescents aged 15 to 18 years, who participate in physical education and sports sessions in public schools in Casablanca, Morocco.Materials and methods: A total of 311 participants, including 156 girls and 154 boys, were included in the study. Each participant maintained a food diary for 3 days during the same study week. Additionally, body composition measurements were taken using bioelectrical impedance analysis (BIA). The PF was assessed using the validated mini-Cooper test (6 min).Results: The results show that the participants had an average total energy intake of 2386.7 ± 492.7 kcal. A significant difference was observed between boys and girls, with average energy intakes of 2468.8 ± 531.1 kcal and 2304.0 ± 437.0 kcal, respectively. These dietary intakes were significantly lower than their needs and nutritional recommendations. The associations of nutritional status, sex, body mass index (BMI) and physical fitness (PF) were tested and a positive correlation was observed following an adequate intake of carbohydrates (CHO) and proteins on Vo2max, while a negative association was observed with regard to Body fat for both sexes. Boys exhibit significantly better PF than girls (p < 0.01). Obese participants had the lowest PF and an unbalanced nutritional status, the adolescents with a normal weight p < 0.01 displayed a high level of PF compared to individuals in other weight categories.Conclusion: The PF is significantly associated with macronutrient intake status and body composition, especially BMI and BF. The Underweight, overweight, and obese students demonstrated poorer performance in physical fitness indices compared to normal-weight. Adolescents adhering to recommended CHO and protein intake levels tend to exhibit enhanced physical fitness. Implementing strategies to encourage students to maintain a balanced diet and engage in regular physical exercise is essential.

4 January 2023 in Progress In Microbes & Molecular Biology
Verified
Journal Article
Open access
PDF file
KBKhawla Bouaouda
Khawla Bouaouda
CEChaimae Elagdi
Chaimae Elagdi
Naoufal El HachlafiNaoufal El Hachlafi
Naoufal El Hachlafi
KMKarima Mohtadi
Karima Mohtadi
MHMohammed Hsaine
Mohammed Hsaine
HTHassan Taki
Hassan Taki
This work focuses on the leaves and stems of Euphorbia nicaeensis All. to confirm its historical use by the Moroccan population. The phytochemical profile of the plant by HPLC-UV-MS/MS was identified for the first time, and the biological activities of each plant organ was evaluated separately by maceration and ultrasonic-assisted extraction. The evaluation of antioxidant activity based on DPPH assay and hydrogen peroxide scavenging assay showed that leaves could be used as a natural source of antioxidants as they provide a potent antioxidant effect (DPPH IC50 = 23.47±0.62 µg/ml), (H2O2 IC50 = 110.27 ± 3.59 µg/ml) compared to stems. These results were proven by HPLC-UV-MS/MS analysis and revealed that E. nicaeensis leaves are richer in phenolic compounds, especially quercetin and derivatives, known for their antioxidant properties. In contrast, the stems could be considered a potential anti-inflammatory agent considering their solid anti-inflammatory activity. The most potent effects were obtained at a concentration of 2 mg/ml, which induced 83.98% and 82.04% inhibition against bovine albumin and egg albumin denaturation, respectively, compared to the control. In addition, the stem phytochemical profile indicated the presence of some compounds with anti-inflammatory effects, such as fargesin and nuciferine. Likewise, the findings showed that ultrasound-assisted extraction was more effective than maceration.

26 June 2023 in Scientific African
Verified
Journal Article
Open access
CEChaimaa Elagdi
Chaimaa Elagdi
KBKhawla Bouaouda
Khawla Bouaouda
RRRachid Rahhal
Rachid Rahhal
MHMohammed Hsaine
Mohammed Hsaine
WBWadi Badri
Wadi Badri
HHHouda EL Hajjouji
Houda EL Hajjouji

Verified
Journal Article
Open access
PDF file
salah LAARAJsalah LAARAJ
salah LAARAJ
Aziz TikentAziz Tikent
Aziz Tikent
MCMohamed Chebaibi
Mohamed Chebaibi
KBKhawla Bouaouda
Khawla Bouaouda
MBMohamed Bouhrim
Mohamed Bouhrim
EKELFAZAZI Kaoutar
ELFAZAZI Kaoutar
Anabasis aretioïdes contain numerous bioactive compounds that provide several advantages, including antioxidant, antibacterial, anticancer, neuroprotective, anti-inflammatory, and antidiabetic characteristics. This study aimed to make a hydroethanolic extract from the aerial part of the plant, analyze its biochemical compounds, and test its biological activities. From HPLC-DAD analysis, cinnamic acid, sinapic acid, and vanillin bioactives were found to be the main compounds in the extract. The spectrometric tests revealed that the extract was rich in flavonoids (8.52 ± 0.32 mg RE/100 g DW), polyphenols (159.32 ± 0.63 mg GAE/100 g DW), and condensed tannins (8.73 ± 0.23 mg CE/100 g DW). The extract showed significant antioxidant activity. There were strong correlations between the amount of flavonoid or polyphenol and the antioxidant assays, including ABTS, DPPH, β-carotene, and TAC. The extract also showed highly effective results against Gram-positive bacteria Staphylococcus aureus and Enterococcus faecalis as well as against Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, and showed promising cytotoxicity against breast cancer cell lines MCF-7 and MDA-MB-231. The in silico modeling of the bioactive compounds contained in the extract illustrated their interaction mode with the active sites of particular target proteins, and it showed that rutin had the strongest effect on stopping NADPH oxidase enzyme, with a glide score of −6.889 Kcal/mol. Sinapic acid inhibited E. coli beta-ketoacyl-[acyl carrier protein] synthase (−7.517 kcal/mol), and apigenin showed high binding affinity to S. aureus nucleoside di-phosphate kinase, with −8.656 kcal/mol. Succinic acid has the strongest anticancer effect for caspase-3, with a glide score of −8.102 kcal/mol. These bioactive components may be beneficial as antioxidant and antibacterial applications in medicine, foods, natural cosmetics, and breast cancer prevention in the future. As a result, the use of this indigenous plant must be considered to maximize its value and preservation.

23 August 2023 in Preprints.org
Verified
Preprint
Open access
PDF file
MOMourad OUKHEDA
Mourad OUKHEDA
KBKhawla Bouaouda
Khawla Bouaouda
KMKarima Mohtadi
Karima Mohtadi
HLHalima Lebrazi
Halima Lebrazi
ADAbdelfettah Derouiche
Abdelfettah Derouiche
HTHassan Taki
Hassan Taki
This study represents the first to examine the nutritional status of Moroccan football players. The aim of this research is to assess the energy and macronutrient intake of professional players from a club competing in the Moroccan professional league "Botola-Pro." Moreover, the study tries to find the potential correlation between nutritional intake and physical performance. A total of 27 professional players participated in a seven consecutive-day study, during a microcycle of the preseason period. The dietary intake was evaluated using the self-reported, complemented by a 24-hour recall. The InBody 120 bioelectrical impedance was employed for assessing body composition measurements, while the Yo-Yo test was utilized to evaluate physical performance; which estimates the maximal oxygen consumption level (VO2max). Among these players, their protein intake levels aligned with recommendations (1.6 to 2.2 g/kg of Body Mass). On the other hand, fat intake slightly surpassed the recommended values. However, carbohydrate intake was relatively subdued compared to recommendations of the Union of European Football Associations (UEFA) in the pre-season training phase. A positive correlation was observed (P-value of < 0.001 and R=0.831) between carbohydrate intake and the measure of VO2max. This suggests that an increase in carbohydrate consumption is associated with enhanced performance, especially within the range of 6 to 8 g/kg BM per day. Conversely, a negative correlation was identified (P-value of < 0.01 and R= − 0.847) between the percentage of dietary fat and the VO2max. The findings of this study highlight areas of nutrition that could be enhanced among professional football players to optimize their performance. In effect, nutritional education is necessary for this category of athletes. Thus, an individual care approach is strongly recommended.

1 January 2026 in International Journal of Food Science
Verified
Journal Article
Open access
KBKhawla Bouaouda
Khawla Bouaouda
MOMourad Oukheda
Mourad Oukheda
HCHanane Choubbane
Hanane Choubbane
CEChaimaa Elagdi
Chaimaa Elagdi
AKAnass Kettani
Anass Kettani
HTHassan Taki
Hassan Taki
This study focuses on examining the chemical composition of Lycium intricatum berries, a plant historically used by the Moroccan population but not extensively studied. Using HPLC‐UV‐MS/MS analysis, we identified significant levels of bioactive compounds. Quercetin and its derivatives were found to be the most abundant compounds across all extracts. The fruit was also found to contain two major carotenoids, 8‐Apo‐b‐carotenal and alloxanthin, and notable levels of phenolic and chlorogenic acids, well‐regarded for their therapeutic effectiveness in treating eye conditions, substantiating the fruit′s historical use. Quantification of phenolic compounds revealed a high content of total polyphenols, total flavonoids, and condensed tannins in all extracts, with solvent‐water mixtures proving to be the most effective for extraction. In terms of biological activities, the antioxidant potential was evaluated using DPPH and hydrogen peroxide tests, showing the ethanol: water (50:50) extract to exhibit strong antioxidant activity (IC 50 = 273.90 ± 0.96 μg /mL, IC 50 = 30.96 ± 1.95 μg /mL), respectively. Furthermore, the acetone: water (80:20) extract demonstrated the most potent antiprotein denaturation effect, assessed using BSA and egg albumin tests. A comparison of extraction methods highlighted that ultrasound‐assisted extraction was more efficient and cost‐effective compared to traditional maceration, especially when using solvents such as methanol, ethanol, acetone, and water. Interestingly, ethyl acetate and hexane were found to facilitate superior extraction through maceration, providing valuable insights into effective extraction strategies.