When studying for a PhD at the post-graduate medical school, Hammersmith, I uncovered the cause of Hartnup disease a rare genetic disorder. Appointed to Makere Medical College in 1960 to establish biochemistry and support the new hospital in Kampala, Uganda, my attention turned to nutritional disorders, which contrasted with the UK. I reported the high prevalence of aflatoxin and primary carcinoma, nutritional and endomyocardial fibrosis, and bladder cancer. On return to the UK to set up a biochemistry laboratory at the Nuffield Institute of Comparative Medicine. With Andrew Sinclair, we reported on the extreme conservation of docosahexaenoic acid in brain structure, growth, and function. In 1972, my wife and I wrote a book (What We Eat Today). In it we predicted failure to pay attention to the need for brain nourishment would lead to an explosion of mental ill health as is now happening. By 1990 there was abundant evidence of the importance of lipids to the brain. I established the Institute of Human Nutrition and Brain Chemistry to move to the East-End of London to research maternal nutrition and low birthweight. Working with Wendy Doyle and Prof Kate Costelo, Homerton Hospital, we produced convincing evidence of poor maternal nutrition, low birthweights, and risk of brain disorders. In 2010 I was invited to join Imperial College to extend research on essential-fatty-acids and neurodevelopmental health. My work has helped the governments of Indonesia, Jpan and Oman.
When studying for a PhD at the post-graduate medical school, Hammersmith, I uncovered the cause of Hartnup disease a rare genetic disorder. Appointed to Makere Medical College in 1960 to establish biochemistry and support the new hospital in Kampala, Uganda, my attention turned to nutritional disorders, which contrasted with the UK. I reported the high prevalence of aflatoxin and primary carcinoma, nutritional and endomyocardial fibrosis, and bladder cancer. On return to the UK to set up a biochemistry laboratory at the Nuffield Institute of Comparative Medicine. With Andrew Sinclair, we reported on the extreme conservation of docosahexaenoic acid in brain structure, growth, and function. In 1972, my wife and I wrote a book (What We Eat Today). In it we predicted failure to pay attention to the need for brain nourishment would lead to an explosion of mental ill health as is now happening. By 1990 there was abundant evidence of the importance of lipids to the brain. I established the Institute of Human Nutrition and Brain Chemistry to move to the East-End of London to research maternal nutrition and low birthweight. Working with Wendy Doyle and Prof Kate Costelo, Homerton Hospital, we produced convincing evidence of poor maternal nutrition, low birthweights, and risk of brain disorders. In 2010 I was invited to join Imperial College to extend research on essential-fatty-acids and neurodevelopmental health. My work has helped the governments of Indonesia, Jpan and Oman.