Maria-Jesus Blanco

Dr. Maria-Jesus Blanco

Sage Therapeutics
orcid

Research Focus & Metrics

Academic Career Length

33Years (1994-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
31 July 2020 in Molecules
Verified
Journal Article
Open access
PDF file
MBMelissa Buskes
Melissa Buskes
Maria-Jesus BlancoMaria-Jesus Blanco
Maria-Jesus Blanco
Cross-coupling reactions have played a critical role enabling the rapid expansion of structure–activity relationships (SAR) during the drug discovery phase to identify a clinical candidate and facilitate subsequent drug development processes. The reliability and flexibility of this methodology have attracted great interest in the pharmaceutical industry, becoming one of the most used approaches from Lead Generation to Lead Optimization. In this mini-review, we present an overview of cross-coupling reaction applications to medicinal chemistry efforts, in particular the Suzuki–Miyaura and Buchwald–Hartwig cross-coupling reactions as a remarkable resource for the generation of carbon–carbon and carbon–heteroatom bonds. To further appreciate the impact of this methodology, the authors discuss some recent examples of clinical candidates that utilize key cross-coupling reactions in their large-scale synthetic process. Looking into future opportunities, the authors highlight the versatility of the cross-coupling reactions towards new chemical modalities like DNA-encoded libraries (DELs), new generation of peptides and cyclopeptides, allosteric modulators, and proteolysis targeting chimera (PROTAC) approaches.

1 January 1999 in Chemical Society Reviews
Verified
Journal Article
Closed access
PDF file
Maria-Jesus BlancoMaria-Jesus Blanco
Maria-Jesus Blanco
MJM. Consuelo Jiménez
M. Consuelo Jiménez
JCJean-Claude Chambron
Jean-Claude Chambron
VHValérie Heitz
Valérie Heitz
MLMyriam Linke
Myriam Linke
JSJean-Pierre Sauvage
Jean-Pierre Sauvage
Rotaxanes are molecular architectures ideally suited for building integrated, multicomponent modular systems, displaying novel chemical and physical properties. In this new field of functional rotaxanes, those incorporating transition metals, which are incidentally used as synthetic templates, are particularly attractive for their photophysical and electronic properties as well as their dynamic behaviour. It is believed that they will provide, in the future, the basic elements for constructing nanoscale machines and motors.

5 November 2018 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
MNMatthew R. Naylor
Matthew R. Naylor
ALAndrew M. Ly
Andrew M. Ly
MHMason J. Handford
Mason J. Handford
DRDaniel P. Ramos
Daniel P. Ramos
CPCameron R. Pye
Cameron R. Pye
RLR. Scott Lokey
R. Scott Lokey

1 June 2017 in Current Opinion in Chemical Biology
Verified
Journal Article
Closed access
MNMatthew R Naylor
Matthew R Naylor
ABAndrew T Bockus
Andrew T Bockus
Maria-Jesus BlancoMaria-Jesus Blanco
Maria-Jesus Blanco
RLR Scott Lokey
R Scott Lokey

1 November 2012 in Bioorganic & Medicinal Chemistry Letters
Verified
Journal Article
Open access
PDPrashant V. Desai
Prashant V. Desai
TRThomas J. Raub
Thomas J. Raub
Maria-Jesus BlancoMaria-Jesus Blanco
Maria-Jesus Blanco
The requirement to cross a biological membrane can be a complex process especially if multidrug transporters such as P-gp must be considered. Drug partitioning into the lipid membrane and efflux by P-gp are tightly coupled processes wherein H-bonding interactions play a key role. All H-bond donors and acceptors are not equal in terms of the strength of the H-bonds that they form, hence it is important to consider their relative strength. Using various examples from literature, we illustrate the benefits of considering the relative strengths of individual H-bonds and introducing intramolecular H-bonds to increase membrane permeability and/or decrease P-gp efflux.

14 January 2020 in ACS Medicinal Chemistry Letters
Verified
Journal Article
Closed access
Maria-Jesus BlancoMaria-Jesus Blanco
Maria-Jesus Blanco
KGKevin M. Gardinier
Kevin M. Gardinier