Mario Jug

Prof. Dr. Mario Jug

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Research Focus & Metrics

Academic Career Length

23Years (2004-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 October 2018 in Pharmaceutics
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Journal Article
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Mario JugMario Jug
Mario Jug
Paola Angela MuraPaola Angela Mura
Paola Angela Mura
Among the different techniques proposed for preparing cyclodextrin inclusion complex in the solid state, mechanochemical activation by grinding appears as a fast, highly efficient, convenient, versatile, sustainable, and eco-friendly solvent-free method. This review is intended to give a systematic overview of the currently available data in this field, highlighting both the advantages as well as the shortcomings of such an approach. The possible mechanisms involved in the inclusion complex formation in the solid state, by grinding, have been illustrated. For each type of applied milling device, the respective process variables have been examined and discussed, together with the characteristics of the obtained products, also in relation with the physicochemical characteristics of both the drug and cyclodextrin subjected to grinding. The critical process parameters were evidenced in order to provide a useful guide for a rational selection of the most suitable conditions for an efficient inclusion complex preparation by grinding, with the final purpose of promoting a wider use of this effective solvent-free cyclodextrin inclusion complex preparation method in the solid state.

1 January 2018 in Journal of Pharmaceutical and Biomedical Analysis
Verified
Journal Article
Closed access
Mario JugMario Jug
Mario Jug
AHAnita Hafner
Anita Hafner
JLJasmina Lovrić
Jasmina Lovrić
MKMaja Lusina Kregar
Maja Lusina Kregar
IPIvan Pepić
Ivan Pepić
JFJelena Filipović-Grčić
Jelena Filipović-Grčić

17 May 2017 in BMC Complementary and Alternative Medicine
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Journal Article
Open access
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NZNatasa Zoric
Natasa Zoric
Ivan KosalecIvan Kosalec
Ivan Kosalec
STSiniša Tomić
Siniša Tomić
IBIvan Bobnjarić
Ivan Bobnjarić
Mario JugMario Jug
Mario Jug
Josipa VlainićJosipa Vlainić
Josipa Vlainić
We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid berberine, active constituent of medically important plants of Barberry species. The effects on membrane, morphological transition, synthesis of ergosterol and the consequent changes in membrane permeability have been studied. Polarization and lipid peroxidation level of the membrane following berberine treatment have been addressed. Minimal inhibitory concentration (MIC) of berberine against C. albicans was 17.75 μg/mL. Cytotoxic effect of berberine was concentration dependent, and in sub-MIC concentrations inhibit morphological transition of C. albicans cells to its filamentous form. Results showed that berberine affects synthesis of membrane ergosterol dose-dependently and induces increased membrane permeability causing loss of intracellular material to the outer space (DNA/protein leakage). Berberine also caused membrane depolarization and lipid peroxidation of membrane constituents indicating its direct effect on the membrane. Moreover, ROS levels were also increased following berberine treatment indicating further the possibility of membrane damage. Based on the obtained results it seems that berberine achieves its anti-Candida activity by affecting the cell membrane.

1 April 2011 in Journal of Pharmaceutical and Biomedical Analysis
Verified
Journal Article
Closed access
Mario JugMario Jug
Mario Jug
Ivan KosalecIvan Kosalec
Ivan Kosalec
FMFrancesca Maestrelli
Francesca Maestrelli
Paola Angela MuraPaola Angela Mura
Paola Angela Mura

1 May 2019 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
ITIvona Tomić
Ivona Tomić
MJMarina Juretić
Marina Juretić
Mario JugMario Jug
Mario Jug
IPIvan Pepić
Ivan Pepić
BČBiserka Cetina Čižmek
Biserka Cetina Čižmek
JFJelena Filipović-Grčić
Jelena Filipović-Grčić

1 May 2010 in Journal of Pharmaceutical and Biomedical Analysis
Verified
Journal Article
Closed access
Mario JugMario Jug
Mario Jug
FMFrancesca Maestrelli
Francesca Maestrelli
MBMarco Bragagni
Marco Bragagni
Paola Angela MuraPaola Angela Mura
Paola Angela Mura