Prof. Dr. Md. Ajijur Rahman
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Academic Career Length
19Years (2008-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications9 October 2019 in Mobile DNA
Journal Article
STSupathep Tansirichaiya
Supathep TansirichaiyaMd. Ajijur RahmanARAdam P. Roberts
Adam P. RobertsTransposable elements in prokaryotes are found in many forms and therefore a robust nomenclature system is needed in order to allow researchers to describe and search for them in publications and databases. Here we provide an update on The Transposon Registry which allocates numbers to any prokaryotic transposable element. Additionally, we present the completion of registry records for all transposons assigned Tn numbers from Tn1 onwards where sequence data or publications exist.
4 September 2011 in Biotechnology Research International
Journal Article
Md. Ajijur RahmanMIMohammad Zahidul Islam
Mohammad Zahidul Islam
AIAnwar Ul Islam
Anwar Ul IslamThis study was performed to isolate actinomycete colonies having antibacterial activity from soil samples collected from different places around Rajshahi, Bangladesh. Thirty actinomycete colonies were isolated in pure culture from five soil samples using Starch-casein-nitrate-agar medium. The isolates were grouped in five color series based on their aerial mycelia color and screened for their antibacterial activity against a range of test bacteria. Sixteen isolates (53.3%) were found to have moderate to high activity against four gram-positive and four gram-negative bacteria. Since many isolates showed inhibitory activity against indicator bacteria, it is suggestive that Bangladeshi soil could be an interesting source to explore for antibacterial secondary metabolites.
1 October 2008 in The American Journal of Tropical Medicine and Hygiene
Journal Article
MIMohammad Zahidul Islam
Mohammad Zahidul IslamATAtsuhide Takesue
Atsuhide Takesue
EKEisaku Kimura
Eisaku Kimura
MIMakoto Itoh
Makoto Itoh
Md. Ajijur RahmanHTHidekazu Takagi
Hidekazu Takagi
+3
We recently reported the production of the recombinant kinesin-related protein of Leishmania donovani with a molecular weight of 42 kd (rKRP42) and the value of the antigen in serum-based ELISA for the diagnosis of visceral leishmaniasis (VL). In this study, the rKRP42 antigen was validated with ELISA using urine samples (rKRP42 urine ELISA). The urine-based ELISA showed 94% sensitivity (108 positives among 115 VL samples) and 99.6% specificity (239 negatives among 240 non-VL samples). The sensitivity and specificity are almost similar to our previous results by ELISA with acetone-treated L. donovani promastigote antigen and direct agglutination test, both methods being done by use of urine samples. A comparison of the rKRP42 urine ELISA with the commercially available urinary antigen detection kit (KAtex) using 108 VL samples showed much higher sensitivity of the ELISA (96.3%) than KAtex (55.6%). The use of the rKRP42 antigen with urine samples will facilitate epidemiologic studies.
11 September 2011 in ISRN Pharmaceutics
Journal Article
HKHajera Khatun
Hajera Khatun
Md. Ajijur RahmanMBMohitosh Biswas
Mohitosh Biswas
AIAnwar Ul Islam
Anwar Ul IslamThis study was done to investigate the effects of water-soluble fraction (WSF) of the fruits of Abelmoschus esculentus L (okra/lady's fingers) on absorption of oral glucose as well as metformin from the gastrointestinal tract in the Long Evans rats. WSF of A. esculentus significantly () reduced the absorption of glucose as studied in the 24 hrs fasting rats. The effect of WSF of A. esculentus on metformin absorption was studied in alloxan-induced diabetic rats. Significant differences () were observed in the average blood glucose level from 2 to 24 hours after metformin therapy in presence (33.6 to 34.2 mmol/L) or absence (15.2 to 20.2 mmol/L) of oral WSF of A. esculentus. In both of the experiments, Na-carboxymethylcellulose (CMC) was used as positive control. The results of this study indicate that A. esculentus may improve glycemic control but should not be taken concurrently with metformin hydrochloride in controlling diabetes mellitus.
15 June 2016 in PLOS ONE
Journal Article
STSupathep Tansirichaiya
Supathep TansirichaiyaMd. Ajijur RahmanAAAgata Antepowicz
Agata AntepowiczPMPeter Mullany
Peter Mullany
ARAdam P. Roberts
Adam P. RobertsIntegrons are genetic elements capable of capturing and expressing open reading frames (ORFs) embedded within gene cassettes. They are involved in the dissemination of antibiotic resistance genes (ARGs) in clinically important pathogens. Although the ARGs are common in the oral cavity the association of integrons and antibiotic resistance has not been reported there. In this work, a PCR-based approach was used to investigate the presence of integrons and associated gene cassettes in human oral metagenomic DNA obtained from both the UK and Bangladesh. We identified a diverse array of gene cassettes containing ORFs predicted to confer antimicrobial resistance and other adaptive traits. The predicted proteins include a putative streptogramin A O-acetyltransferase, a bleomycin binding protein, cof-like hydrolase, competence and motility related proteins. This is the first study detecting integron gene cassettes directly from oral metagenomic DNA samples. The predicted proteins are likely to carry out a multitude of functions; however, the function of the majority is yet unknown.
3 October 2012 in The American Journal of Tropical Medicine and Hygiene
Journal Article
MIMohammad Zahidul Islam
Mohammad Zahidul IslamMIMakoto Itoh
Makoto ItohAIAnwar Ul Islam
Anwar Ul Islam
AEA R M Saifuddin Ekram
A R M Saifuddin EkramMd. Ajijur RahmanEKEisaku Kimura
Eisaku Kimura
+3
We reported a highly sensitive and specific enzyme-linked immunosorbent assay (ELISA) that detects immunoglobulin G (IgG) in urine using rKRP42 antigen for the diagnosis of visceral leishmaniasis (VL). The ELISA was applied to study chronological change in antibody titers in five study areas in Rajshahi district, Bangladesh. A total of 585 subjects without a past VL history were examined at least three times in the 30-month follow-up period; of these subjects, 137 (23.4%) subjects became ELISA-positive at least one time during the study. Among the positive cases, 40 (29.2%) subjects developed clinical VL, and 31 (77.5%) of these subjects showed IgG titers of ≥ 1,000 U more than one time in the study period. Considering only the first ELISA results, 22 subjects with IgG titers of ≥ 1,000 U could be found, and 21 (95.5%) of these subjects turned out to be clinical cases. The high urinary IgG titers (≥ 1,000 U) will help predict possible clinical VL cases and thus, identify an outbreak in its earlier stage.
About Me
Professor Dr. Md. Ajijur Rahman is a Professor in the Department of Pharmacy at the University of Rajshahi, Bangladesh, and an internationally recognized researcher in antimicrobial resistance (AMR), functional metagenomics, integron biology, and natural product-based antibiotic discovery. He obtained First Class First positions in both his BPharm and MPharm degrees from the University of Rajshahi and later earned a PhD from University College London (UCL), UK, as a Commonwealth Scholar.
His research focuses on AMR mechanisms, mobile genetic elements, antibiotic-producing microorganisms, medicinal mushrooms, and public health pharmacy. He has made significant contributions to the characterisation of integron-associated resistance genes and the discovery of novel antimicrobial-producing bacteria from Bangladeshi environments.
Following his PhD, Dr. Rahman completed postdoctoral research at the Liverpool School of Tropical Medicine, UK, where he investigated antibiotic resistance genes using functional metagenomic approaches. He has published more than 40 peer-reviewed articles and received over 800 citations worldwide.
Dr. Rahman is the recipient of the prestigious FEMS–ASM Mäkelä-Cassel Award for Early Career Scientists. He currently supervises PhD and postgraduate researchers in AMR, microbiology, natural products, and public health. Beyond academia, he is an active science communicator and has authored more than 40 editorials in daily newspapers and portals.