The Tavsanli Zone in northwest Turkey is intruded by many Late Cretaceous to Eocene (91-45 Ma) calc-alkaline granitoids, of which the Günyüzü pluton in the Eskisehir region is the least studied. The Günyüzü rocks are high-K, calc-alkaline (I-type) intrusions, and are comprised of diorite, granodiorite, granite, and granite porphyry. Typical minerals are plagioclase, K-feldspar, quartz, biotite, hornblende and Fe-Ti oxides. Chondrite-normalized REE patterns for the Günyüzü rocks are moderately fractionated and have small negative Eu anomalies. They are enriched in LILE and LREE relative to HFSE, showing characteristics of arc-related granitoids. Low values of molar K₂O/Na₂O, Al₂O₃/(FeO+MgO+TiO₂), and (Na₂O+K₂O)/(FeO+MgO+TiO₂) ratios demonstrate that the Günyüzü magma(s) were produced from mafic lower crustal rocks.

Background: Despite the identification of various environmental factors that increase the risk of multiple sclerosis (MS), the effects of many factors on the etiology of MS remain to be elucidated. In this study, we aimed to investigate the effects of radon, a factor previously studied in relation to various other neurodegenerative diseases, on the epidemiology of MS. Methods: A door-to-door field study was conducted in residential areas with relatively high and low radon gas concentrations to determine the prevalence of MS. The study area comprises the Bolvadin and İhsaniye regions, which have different geological characteristics, such as seismic activity, active faults, and distributions of volcanic rocks. CR-39 detectors, with an accepted limit of 300 Bq/m³, were utilized to measure radon gas concentrations. During the screening field, the patients diagnosed with multiple sclerosis were confirmed with their hospital records. Mc Donald’s revised diagnostic criteria were used for multiple sclerosis diagnosis. Results: The regions were grouped into higher radon areas and lower radon areas. The İhsaniye city center, Kayıhan, Kemerkaya, Döğer, and Bolvadin city center were classified as higher radon regions, whereas Dişli, Yaylabağı, Gazlıgöl, and Özburun were identified as lower radon regions. A total of 40,841 individuals were surveyed in the field. The crude MS prevalence was 41.8/100,000 in settlements with high radon gas concentrations and 20.5/100,000 in settlements with low radon gas concentrations. Conclusions: In this study, we revealed that the prevalence of MS was greater in settlements with high radon gas concentrations than in settlements with low radon gas concentrations. These results demonstrated that radon gas is an important environmental risk factor in the etiopathogenesis of MS.