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Dr. Min Kyu Kim
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Academic Career Length
27Years (2000-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 January 2016 in Journal of Investigative Dermatology
Journal Article
JOJi Won Oh
Ji Won Oh
JKJennifer Kloepper
Jennifer Kloepper
ELEwan A. Langan
Ewan A. Langan
YKYongsoo Kim
Yongsoo KimJYJoongyeub Yeo
Joongyeub Yeo
MPMaksim V. Plikus
Maksim V. Plikus +10
1 March 2003 in Cancer Science
Journal Article
YSYoung Kwan Sung
Young Kwan Sung
SHSun Young Hwang
Sun Young Hwang
MPMi Kyung Park
Mi Kyung Park
MFMohammad Farooq
Mohammad Farooq
IHIn Sook Han
In Sook Han
MKMin Kyu Kim
Min Kyu Kim +2
To identify candidate genes that could be used as diagnostic and therapeutic targets for hepatocellular carcinoma (HCC), we searched for the genes that are overexpressed in HCC by combining representational difference analysis and microarray. Genes such as glypican‐3 (GPC3), insulin‐like growth factor 2, long‐chain fatty‐acid‐coenzyme A ligase 4, farnesyl diphosphate synthase were frequently identified in our screening. Northern blot analysis with these four genes confirmed their overexpression in HCC. Among them we found that GPC3 transcript is upregulated in six out of seven cases of HCC. Immunoblot and immunohistochemical staining using polyclonal anti‐GPC3 antibodies further confirmed that GPC3 protein is indeed increased in HCC tumor samples. We also found that GPC3 is secreted into culture media from cell lines derived from HCC. We conclude that GPC3 is a good molecular marker for HCC. (Cancer Sci 2003; 94: 259–262)
1 May 2003 in Cancer Science
Journal Article
YSYoung Kwan Sung
Young Kwan Sung
SHSun Young Hwang
Sun Young Hwang
MPMi Kyung Park
Mi Kyung Park
HBHan Ik Bae
Han Ik Bae
WKWoo Ho Kim
Woo Ho Kim
MKMin Kyu Kim
Min Kyu Kim +1
Fatty acid‐CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified arachidonic acid (AA) level in cells. It has been shown that FACL4 blocks apoptosis and promotes colon carcinogenesis by lowering the cellular level of unesterified AA. Consistent with this, FACL4 is upregulated in colon adenocarcinoma. The status of FACL4 in other tumors including hepatocellular carcinoma (HCC) is not known. Here, we report that FACL4 is overexpressed in human HCC compared with adjacent normal liver tissues. FACL4 mRNA and protein were overexpressed in 5 out of 12 (41.7%) and 3 out of 8 (37.5%) cases of HCC, respectively. Immunohistochemical staining showed strong fine granular intracytoplasmic staining in tumor cells, whereas we observed occasional weak staining in normal liver tissues surrounding the tumors. We found that 14 out of 37 (37.8%) HCC expressed moderate to strong FACL4 immunostaining. Both normal adult and fetal liver tissues showed very weak to no detectable staining, whereas 3 out of 10 (30%) cirrhotic livers expressed weak staining. In addition, we found that 4 out of 8 (50%) human hepatoma cell lines expressed high levels of FACL4 by northern blot analysis. Our results show that FACL4 is a new molecular marker for HCC and suggest that the FACL4 pathway may be involved in liver carcinogenesis. (Cancer Sci 2003; 94: 421–424)
25 January 2013 in Experimental Dermatology
Journal Article
MKMi-hee Kwack
Mi-hee KwackMKMin Kyu Kim
Min Kyu KimJKJung Chul Kim
Jung Chul KimYSYoung Kwan Sung
Young Kwan SungFindings of recent studies have demonstrated modulation of Wnt/β-catenin signalling by Wnt5a, which is highly expressed in hair follicular dermal papilla (DP) in vivo. Here, we investigated the question of whether Wnt5a can affect canonical Wnt/β-catenin signalling in DP cells. Treatment with Wnt5a resulted in attenuation of Wnt3a-mediated elevation of β-catenin signalling, which was increased by Wnt5a siRNA transfection in cultured DP cells, as examined by reporter assay. In addition, treatment with Wnt5a resulted in repressed Wnt3a-mediated expression of Axin2, EP2 and LEF1 in cultured DP cells, whereas Wnt5a siRNA transfection resulted in increased Wnt3a-mediated expression of the genes in isolated DPs of cultured hair follicles. Moreover, treatment with Wnt5a resulted in attenuation of Wnt3a-mediated accumulation of β-catenin in the nucleus in DP cells. Our data strongly suggest that Wnt5a acts as an autocrine factor and attenuates canonical Wnt signalling pathway in human DP cells.
18 April 2016 in Experimental Dermatology
Journal Article
MKMi Hee Kwack
Mi Hee Kwack
JAJi Sup Ahn
Ji Sup Ahn
JJJeong Hyun Jang
Jeong Hyun Jang
JKJung Chul Kim
Jung Chul Kim
YSYoung Kwan Sung
Young Kwan Sung
MKMin Kyu Kim
Min Kyu Kim1 January 2020 in Annals of Dermatology
Journal Article
MJMee Sook Jun
Mee Sook JunMKMi-hee Kwack
Mi-hee KwackMKMin Kyu Kim
Min Kyu KimJKJung Chul Kim
Jung Chul KimYSYoung Kwan Sung
Young Kwan SungJun MS, et al. Ann Dermatol. 2020 Oct;32(5):388-394. https://doi.org/10.5021/ad.2020.32.5.388
About Me
I completed both my Master’s and PhD programs at the School of Medicine, Kyungpook National University, and I am currently in a postdoctoral program. My primary research areas include the mechanisms of androgenetic alopecia and hair follicle regeneration. Publications: First-author Paper: "Expression level of leucine-rich repeat containing 15 regulates characteristics of dermal papilla cells of human hair follicle". Kim MK, Kwack MH, Kim MK, Kim JC, Sung YK.Journal of Dermatological Science. 2021 Feb;101(2):134-137. Co-author Papers: "Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression." Kang YR, Bak SS, Kim MK, Joo HW, Mali NM, Shin MJ, Kim MK, Kim JC, Oh JW, Sung YK.Journal of Investigative Dermatology. 2019 Aug;139(8):1824-1828.e2; "Bioengineering of Hair Follicle-like Structure for Validation of Hair Growth Promoting Compounds." Joo HW, Kim MK, Bak SS, Sung YK.Bioengineering (Basel). 2022 Nov 3;9(11):645; "Establishment and characterization of matched immortalized human frontal and occipital scalp dermal papilla cell lines from androgenetic alopecia." Kwack MH, Hamida OB, Kim MK, Kim MK, Sung YK.Scientific Reports. 2023 Dec 5;13(1):21421.