Mohammad earned his PhD in Chemistry from Temple University and completed his postdoctoral training at the University of Virginia School of Medicine. In his PhD work, he developed second-harmonic light scattering to reveal membrane dynamics, drug interaction, and bacterial surface properties. In his postdoc, he worked out through unbiased resistance library screening and biochemistry how a natural lacritin tear proteoform targets P. aeruginosa outer membrane YaiW to enter the periplasm where it binds and inhibits PotH of polyamine and FeoB of ferrous iron transporters. The outcome is suppression of aerobic/anaerobic respiration that is enhanced in clinical isolates by synergy with the tear thrombin fragment (April 2025 cover, J. Biol. Chem., JBC). In another JBC article (2021), he discovered that tear lacritin proteoforms play an essential role in the stabilization of the human tear film and restore corneal epithelial homeostasis under conditions of inflammatory stress. His research bridges chemistry and microbiology to advance our understanding of disease mechanisms and therapeutics. He has served as an invited reviewer for Exp. Eye Res. (2020-23), mentored several trainees throughout his academic career, and received the Daniel Swern Fellowship (2017), the Outstanding Graduate Research Award in Chemistry (2018), the American Society for Cell Biology Travel Grant (2019), National Eye Institute Travel Grants (2021, 2023), and the ASBMB Postdoctoral Researcher Award (2023).
Mohammad earned his PhD in Chemistry from Temple University and completed his postdoctoral training at the University of Virginia School of Medicine. In his PhD work, he developed second-harmonic light scattering to reveal membrane dynamics, drug interaction, and bacterial surface properties. In his postdoc, he worked out through unbiased resistance library screening and biochemistry how a natural lacritin tear proteoform targets P. aeruginosa outer membrane YaiW to enter the periplasm where it binds and inhibits PotH of polyamine and FeoB of ferrous iron transporters. The outcome is suppression of aerobic/anaerobic respiration that is enhanced in clinical isolates by synergy with the tear thrombin fragment (April 2025 cover, J. Biol. Chem., JBC). In another JBC article (2021), he discovered that tear lacritin proteoforms play an essential role in the stabilization of the human tear film and restore corneal epithelial homeostasis under conditions of inflammatory stress. His research bridges chemistry and microbiology to advance our understanding of disease mechanisms and therapeutics. He has served as an invited reviewer for Exp. Eye Res. (2020-23), mentored several trainees throughout his academic career, and received the Daniel Swern Fellowship (2017), the Outstanding Graduate Research Award in Chemistry (2018), the American Society for Cell Biology Travel Grant (2019), National Eye Institute Travel Grants (2021, 2023), and the ASBMB Postdoctoral Researcher Award (2023).