Background: A nature-based social prescription (NBSP) is an approach to improving mental health outcomes that involves prescribing nature-based interventions as complementary or alternative therapy to traditional ones. A variety of advantages are available from NBSP for people looking to enhance their mental well-being. The effect size of the nature-based social prescriptions (NBSPs) has not been thoroughly evaluated by systematic reviews and meta-analyses.Objectives: The current study aimed to analyze existing studies and conduct a meta-analysis to determine the overall effect size of the nature-based social prescriptions (NBSP’s) outcomes on mental health.Methods: By choosing the relevant papers from among those that were available, a meta-analysis was carried out in the current study. A systematic search of electronic databases (Pub Med, Web of Science, Scopus, Cochrane Library, Embase, CINAHL, and PsychINFO) was conducted to identify relevant studies. Studies were included if they evaluated the effects of NBSP on mental health outcomes. Effect sizes were calculated using the random effects model.Results: Meta-analysis of interventions statistics shows that CBT (SMD −0.0035; 95% CI: [−0.5090; 0.5020]; Tau^2: 0.1011; Tau: 0.318), digital intervention (SMD −0.3654; 95% CI: [−0.5258; 1.2566]; Tau^2: 0.2976, Tau: 0.5455), music intervention (SMD −2.1281; 95% CI: [−0.4659; 4.7221]; Tau^2: 3.4046; Tau:1.8452), and psychological interventions (SMD −0.8529; 95% CI: [0.3051; 1.4007]; Tau^2: 0.1224; Tau: 0.3499) do not significantly impact. The other interventions [social belongingness, communication training, blue intervention, nature-based education, cognitive behavior group therapy (CBGT), social prescribing coordinator, self-help intervention, participatory, organizational intervention, inpatient services, brief diet, internet-based intervention, prenatal intervention, yoga and meditation, ergonomics training program, yoga nidra intervention, and storytelling] highlighted above are significant.Conclusion: The conclusion of the meta-analysis supports the idea that incorporating nature-based social prescription interventions into mental healthcare plans can effectively complement traditional therapies and improve mental health outcomes.Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023412458, CRD42023412458.

Background: During the COVID-19 pandemic, cellphone health apps and virtual reality fitness for treating neurological disorders such as Parkinson’s were beneficial. Virtual reality has been used to treat PTSD, depression, anxieties, dementia, ADHD, dyslexia, and pain control in various settings. Virtual reality exercise has been studied for its effects on biological, mental, rehabilitation, behavior, and attitude management. Purpose: This research aimed to find out the role of virtual reality fitness (VRF) for behavior management during the COVID-19 pandemic concerning the demographic characteristics of the study participants and the use of fitness and health apps. Methods: The population for the current study was Chinese residents across China who were in home isolation during the early pandemic in China. According to the study objective, a convenience sampling method was used to collect the primary data through an online survey. SPSS-25 statistical software was used to analyze the demographic information and clean and prepare the data to test all proposed hypotheses. The proposed research framework was examined using the structural equation modeling (SEM) approach through SmartPLS 3.0 software. Results: The structural equation model analysis shows that all the proposed hypotheses (H1: β = 0.137, t = 10.454, p = < 0.000; H2: β = 0.256, t = 16.824, p = < 0.000; H3: β = 0.418, t = 27.827, p = < 0.000; H4: β = 0.133, t = 8.913, p = < 0.000; H5: β = 0.076, t = 4.717, p = < 0.000; H6: β = 0.162, t = 10.532, p = < 0.000; H7: β = 0.384, t = 26.645, p = < 0.000) are confirmed. Conclusion: Fitness and health apps with virtual reality fitness play a substantial role in improving the overall quality of life and positively influencing behavior and attitude.

Background: E-health apps play a vital role in the era of the COVID-19 pandemic. More people across the globe have started to use fitness and health apps to mitigate the COVID-19 negative impacts on the health-related quality of life. E-health treatments are becoming more common these days. Aim: The present research aim was to explore the mediating role of digital platforms for physical activity and fitness with demographic characteristics among Chinese people during the pandemic. Methods: The primary data was collected through an online survey across China under the snowball sampling technique. A total of 5351 respondents took part in the online questionnaire survey. After quantification and quality check of the data, a total of 5000 respondents’ responses were added in the final analysis. The collected data were analyzed by using SPSS-25 and SmartPLS 3.0 software. Results: The structural equation model analysis H1 (β = 0.227, t = 18.725, p = < 0.000), H2 (β = 0.225, t = 17.892, p = < 0.000), H3 (β = 0.229, t = 17.845, p = < 0.000), H4 (β = 0.54, t = 60.928, p= < 0.000), H5 (β = 0.553, t = 57.291, p = < 0.000), H6 (β = 0.559, t = 56.956, p = < 0.000), H7 (β = 0.358, t = 24.779, p = < 0.000), H8 (β = 0.259, t = 19.617, p = < 0.000) and H9 (β = 0.288, t = 19.92, p = < 0.000) results confirm the proposed hypothesis of the study. Conclusion: E-health apps are playing a vital role in maintaining an active lifestyle through physical activity. Fitness and health apps can promote physical activity and improve health-related quality of life. Results of the current study concluded that E-health apps are promising to promote physical activity and fitness during the COVID-19 preventive measures.

Neurodegenerative disorders could be a most important health issue within the 21st century. In the recent past; there has been a growing interest in medicinal plants. Chemical fruits and vegetables are said to decrease the possibility of many chief ailments, together with cardiovascular and cancer disorders as well as neurodegenerative ailments. Hence, who eat more fruits and vegetables may be less threaten for developing certain diseases caused by neurological dysfunction. The present review provides an overview of the about 14 most important plants used for neurological disorders and explores their neurological protection for the development of new pharmacological potential drugs. The data sources including the publications on Google Scholar, PubMed, and Science Direct. Publications searched with no particular time restriction in order to get a holistic and comprehensive view of the research done on this topic so far. Therefore, we present a systematic approach for herbal medicine as neuroprotective agent. From ancient time the herbal medicines are used to cure neurological symptoms. While the exact pharmacology of these herbs has not yet been set on, some of them have anti-inflammatory or antioxidant properties on different peripheral systems. The significant variety of medicinal plants makes it an essential source of healthy compounds compared to current therapeutic agents. In this review, the importance of phytochemicals for the function of neurological protection and other related disorders, in particular, the process mechanism and therapeutic prospective will be emphasize.

Introduction: Hepatocellular carcinoma (HCC) is recognized as the prime and lethal form of liver cancer caused by the hepatitis B virus (HBV) and hepatitis C virus (HCV) globally. Lactate is an end product of glycolysis that influences epigenetic expression through histone lactylation. While MKI67 and RACGAP1 play crucial roles in HBV- and HCV-related HCC. However, the role of lactylation-related genes (LRGs) effects in this context remains unclear. This study innovatively explored the role of LRGs in HBV/HCV-associated HCC, identifying novel biomarkers for diagnosis and prognosis.Methods: The present study used various online databases for analysis, and the findings were validated via immunohistochemical (IHC) analysis of HCC patient samples (n=60).Results: We identified six signature LRGs (ALB, G6PD, HMGA1, MKI67, RACGAP1, and RFC4) possess prognostic potential, correlation with immune infiltration, and lactylation-related pathways, providing novel insights into tumor microenvironment (TME) of HCC. Moreover, MKI67 and RACGAP1 were significantly associated with HBV- and HCV-related HCC. IHC confirmed these findings, with high expression of MKI67 and RACGAP1 was significantly linked with HBV/HCV-associated HCC compared to non-viral HCC. The expression is also significantly associated with key clinical variables.Conclusion: Our results suggest that MKI67 and RACGAP1 could serve as promising biomarkers for detecting and predicting HCC caused by HBV/HCV via lactylation, opening a new direction for immune-targeted therapies.

Bevacizumab, a humanized monoclonal antibody targeting vascular endothelial growth factor (VEGF), was the first anti-angiogenic agent incorporated into metastatic colorectal cancer treatment strategies and demonstrated broad-spectrum anti-tumor efficacy. Commonly reported adverse events include hypertension, proteinuria, gastrointestinal perforation, bleeding, and thromboembolism. However, there are only a few reports on abdominal aortic aneurysms (AAA) as a complication of bevacizumab therapy. Given the high risk of fatal rupture with AAA, we present a case of bevacizumab-associated AAA to raise clinician awareness of this possible, rare, and serious adverse reaction.