Human health is harmed by air pollution. The objective of this research was to show that air pollution in Pakistan is getting worse and is negatively impacting people’s health. IQ Air and the Institute for Health Metrics and Evaluation provided the data for this descriptive research. Monthly data of PM_2.5 μg/m³ from ten different localities across Pakistan are used to show spatial distribution through the geospatial technique of interpolation. The findings show that two third of the country has high PM_2.5 concentration, with Lahore as the most polluted city. In Pakistan, solid fuel use has decreased, leading to a decline in associated mortality and morbidity. However, there have been significant increases in PM_2.5 and ozone levels, resulting in a rise in the country’s overall health burden caused by air pollution. Furthermore, the number of deaths attributed to air pollution has also increased since 1990. A total of 57% of chronic obstructive pulmonary disease, 40% of lower respiratory infections, 36% of ischemic stroke, 35% of ischemic heart diseases, 32% of lung cancer, 25% of diabetes, and 20% of neonatal outcomes are directly attributed to air pollution in Pakistan. The main contributors to air pollution are population growth, growing motorization, and unsustainable energy usage. The main challenges due to air pollution control and monitoring in Pakistan include a lack of awareness, poor policy creation and implementation, the use of improper fuel, rising energy demands, and an absence of pollution monitoring stations in most cities. Therefore, there is a need for a robust air pollution monitoring system, increased public awareness, and the implementation of clean and sustainable policies to regulate this environmental health issue.