Nadia Flexner

Ms. Nadia Flexner

University of Toronto Temerty Faculty of Medicine

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 March 2021 in Advances in Nutrition
Verified
Journal Article
Open access
JSJoseph Alvin Santos
Joseph Alvin Santos
DTDejen Tekle
Dejen Tekle
EREmalie Rosewarne
Emalie Rosewarne
NFNadia Flexner
Nadia Flexner
LCLaura Cobb
Laura Cobb
KTKathy Trieu
Kathy Trieu
In 2013, the WHO recommended that all member states aim to reduce population salt intake by 30% by 2025. The year 2019 represents the midpoint, making it a critical time to assess countries' progress towards this target. This review aims to identify all national salt reduction initiatives around the world in 2019, and to quantify countries' progress in achieving the salt reduction target. Relevant data were identified through searches of peer-reviewed and gray literature, supplemented with responses from prefilled country questionnaires sent to known country leads of salt reduction or salt champions, WHO regional representatives, and international experts to request further information. Core characteristics of each country's strategy, including evaluations of program impact, were extracted and summarized. A total of 96 national salt reduction initiatives were identified, representing a 28% increase in the number reported in 2014. About 90% of the initiatives were multifaceted in approach, and 60% had a regulatory component. Approaches include interventions in settings (n= 74), food reformulation (n = 68), consumer education (n = 50), front-of-pack labeling (n = 48), and salt taxation (n = 5). Since 2014, there has been an increase in the number of countries implementing each of the approaches, except consumer education. Data on program impact were limited. There were 3 countries that reported a substantial decrease (>2 g/day), 9 that reported a moderate decrease (1-2 g/day), and 5 that reported a slight decrease (<1 g/day) in the mean salt intake over time, but none have yet met the targeted 30% relative reduction in salt intake from baseline. In summary, there has been an increase in the number of salt reduction initiatives around the world since 2014. More countries are now opting for structural or regulatory approaches. However, efforts must be urgently accelerated and replicated in other countries and more rigorous monitoring and evaluation of strategies is needed to achieve the salt reduction target.

27 September 2023 in Nutrients
Verified
Journal Article
Open access
PDF file
GHGuanlan Hu
Guanlan Hu
NFNadia Flexner
Nadia Flexner
MTMaría Victoria Tiscornia
María Victoria Tiscornia
Mary LabbeMary Labbe
Mary Labbe
The consumption and availability of ultra-processed foods (UPFs), which are associated with an increased risk of noncommunicable diseases, have increased in most countries. While many countries have or are planning to incorporate UPF recommendations in their national dietary guidelines, the classification of food processing levels relies on expertise-based manual categorization, which is labor-intensive and time-consuming. Our study utilized transformer-based language models to automate the classification of food processing levels according to the NOVA classification system in the Canada, Argentina, and US national food databases. We showed that fine-tuned language models using the ingredient list text found on food labels as inputs achieved a high overall accuracy (F1 score of 0.979) in predicting the food processing levels of Canadian food products, outperforming traditional machine learning models using structured nutrient data and bag-of-words. Most of the food categories reached a prediction accuracy of 0.98 using a fined-tuned language model, especially for predicting processed foods and ultra-processed foods. Our automation strategy was also effective and generalizable for classifying food products in the Argentina and US databases, providing a cost-effective approach for policymakers to monitor and regulate the UPFs in the global food supply.

8 February 2022 in Nutrients
Verified
Journal Article
Open access
PDF file
VHVirginie Hamel
Virginie Hamel
MNMilena Nardocci
Milena Nardocci
NFNadia Flexner
Nadia Flexner
Jodi BernsteinJodi Bernstein
Jodi Bernstein
Mary LabbeMary Labbe
Mary Labbe
JMjean-claude moubarac
jean-claude moubarac
Excess sugar consumption can lead to noncommunicable diseases (NCDs) such as type 2 diabetes. Increasingly, ultra-processed foods (UPF) are suspected to be great contributors to free sugars intake in the population’s diet. Thus, the aim of this study was to investigate the association between UPF consumption and free sugars intake in the Canadian population. We used data from one 24 h-recall of the nationally representative 2015 Canadian Community Health Survey–Nutrition (CCHS). Food items were classified according to the NOVA system, and to estimate free sugars intake, we used the University of Toronto’s Food Label Information Program (FLIP) 2017 database. Results: Almost half of the population’s energy intake (45.7%) came from UPF. On average, 221.5 kcal/day came from free sugars, and most of these calories (71.5%) came from UPF. Public health policies aiming to decrease consumption of UPF should be a priority considering their important contribution to sugar intake in the population.

11 April 2023 in Nutrients
Verified
Journal Article
Open access
PDF file
NFNadia Flexner
Nadia Flexner
Jodi BernsteinJodi Bernstein
Jodi Bernstein
MWMadyson V. Weippert
Madyson V. Weippert
MLMarie-Eve Labonté
Marie-Eve Labonté
ACAnthea Christoforou
Anthea Christoforou
Mary LabbeMary Labbe
Mary Labbe
Free sugars are a major source of calories in diets and contribute to the burden of many non-communicable diseases (NCDs). The World Health Organization (WHO) recommends reducing free sugars intake to less than 10% of total energy. This study aimed to estimate the number of diet-related NCD deaths which could be averted or delayed if Canadian adults were to reduce their calorie intake due to a systematic 20% reduction in the free sugars content in foods and beverages in Canada. We used the Preventable Risk Integrated ModEl (PRIME) to estimate the potential health impact. An estimated 6770 (95% UI 6184–7333) deaths due to diet-related NCDs could be averted or delayed, mostly from cardiovascular diseases (66.3%). This estimation would represent 7.5% of diet-related NCD deaths observed in 2019 in Canada. A 20% reduction in the free sugars content in foods and beverages would lead to a 3.2% reduction in calorie intake, yet an important number of diet-related NCD deaths could be averted or delayed through this strategy. Our findings can inform future policy decisions to support Canadians’ free sugars intake reduction, such as proposing target levels for the free sugars content in key food categories.

25 April 2023 in Foods
Verified
Journal Article
Open access
PDF file
Jodi BernsteinJodi Bernstein
Jodi Bernstein
ACAnthea Christoforou
Anthea Christoforou
ANAlena (Praneet) Ng
Alena (Praneet) Ng
MWMadyson Weippert
Madyson Weippert
CMChristine Mulligan
Christine Mulligan
Mary LabbeMary Labbe
Mary Labbe
Recommendations suggest limiting the intake of free sugar to under 10% or 5% of calories in order to reduce the risk of negative health outcomes. This study aimed to examine Canadian free sugar intake and model how intakes change following the implementation of a systematic reformulation of foods and beverages to be 20% lower in free sugar. Additionally, this study aimed to examine how calorie intake might be impacted by this reformulation scenario. Canadians’ free sugar and calorie intakes were determined using free sugar and calorie data from the Food Label Information Program (FLIP) 2017, a Canadian branded food composition database, and applied to foods reported as being consumed in Canadian Community Health Survey—Nutrition (CCHS-Nutrition) 2015. A “counterfactual” scenario was modelled to examine changes in intake following the reformulation of foods to be 20% lower in free sugar. The overall mean free sugar intake was 12.1% of calories and was reduced to align with the intake recommendations at 10% of calories in the “counterfactual” scenario (p < 0.05). Calorie intake was reduced by 3.2% (60 calories) in the “counterfactual” scenario (p < 0.05). Although the overall average intake was aligned with the recommendations, many age/sex groups exceeded the recommended intake, even in the “counterfactual” scenario. The results demonstrate a need to reduce the intake of free sugar in Canada to align with dietary recommendations, potentially through reformulation. The results can be used to inform future program and policy decisions related to achieving the recommended intake levels of free sugar in Canada.

3 November 2023 in medRxiv
Verified
Preprint
Open access
PDF file
NFNadia Flexner
Nadia Flexner
AJAmanda C. Jones
Amanda C. Jones
BABen Amies-Cull
Ben Amies-Cull
LCLinda Cobiac
Linda Cobiac
ENEduardo Augusto Fernandes Nilson
Eduardo Augusto Fernandes Nilson
Mary LabbeMary Labbe
Mary Labbe
Background: High dietary sodium is the main dietary risk factor for non-communicable diseases due to its impact on cardiovascular diseases, the leading cause of death globally. The Government of Canada has taken measures to reduce average dietary sodium intakes, such as setting voluntary sodium reduction targets for packaged foods and recently approving regulations mandating ‘high in’ front-of-pack labeling (FOPL) symbols. Objectives: To estimate the number of avoidable ischemic heart disease (IHD) and stroke incidence cases, and their associated healthcare cost and Quality-Adjusted Life Year (QALY) savings resulting from different sodium reduction strategies and recommendations in Canada. Methods: We used the PRIMEtime model, a proportional multi-state lifetable model. Outcomes were modeled over the lifetime of the population alive in 2019, at a 1.5% discount rate, and from the public healthcare system perspective. Nationally representative data were used as inputs for the model. Results: Fully meeting Health Canada’s sodium reduction targets was estimated to prevent 219,490 (95% UI, 73,409–408,630) cases of IHD, and 164,435 (95% UI, 56,121–305,770) strokes. This led to a gain of 276,185 (95% UI, 85,414–552,616) QALYs, and healthcare costs savings of CAD$ 4,212(95% UI, 1,303–8,206) million over the lifetime of the 2019 cohort. Sodium reduction intake through FOPL regulations has the potential to prevent between 35,930 (95% UI, 8,058– 80,528) and 124,744 (95% UI, 40,125–235,643) cases of IHD, and between 26,869 (95% UI, 5,235–61,621) and 93,129 (95% UI, 30,296–176,014) strokes. This results in QALY gains ranging from 45,492 (95% UI, 10,281–106,579) to 157,628 (95% UI, 46,701–320,622), and healthcare costs savings ranging from CAD$ 695 (95% UI, 160–1,580) to CAD$ 2,415 (95% UI, 722–4,746) million over the lifetime of the 2019 Canadian cohort. Greater health and healthcare costs gains were estimated if Canadians were to meet the population-level sodium intake recommendations of the World Health Organization (2,000 mg/day) and the Adequate Intake recommendation (1,500 mg/day). All sodium reduction strategies tested were cost saving. Conclusions: Reducing population-level sodium intakes is feasible and has the potential to improve health outcomes and save healthcare costs in Canada. From interventions tested, most health and healthcare costs gains were attributed to fully meeting sodium reduction targets, which highlights the importance of changing the voluntary nature of these targets to mandatory. A combination of strategies, mandatory sodium reduction targets and implementation of the ‘high in’ FOPL symbol would provide the most benefit from a public health standpoint.